Navigation Links
From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
Date:3/26/2012

ms the basis of many of today's therapeutic protein drugs, including, for example, the protein GCase, used in a drug that treats Gaucher's disease. To do so, they artificially introduced the machinery of glycosylation the chemical process by which proteins become glycoproteins into E. coli cells, rather than animal cells.

The synthetic pathway they designed, which can be tailored to many amino acid acceptor sites to make different drugs, starts with native enzymes in E. coli. Added to that was a mixture of four enzymes taken from yeast cells, which triggered the biosynthesis of a specific glycan (sugar structure) that resembles the core structure found in virtually all eukaryotic glycans. A fifth enzyme from the bacterium, Campylobacter jejuni, transferred these core glycans to pre-engineered protein acceptor sites, resulting in the desired glycoproteins.

DeLisa and his colleagues are now working to improve their approach that they call "glycans by design" using the enzyme-based protein production method to specifically tailor sugar structures to make many different glycans and glycoproteins.


'/>"/>
Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Seafarers scourge provides hope for biofuel future
2. Disinfectants can make bacteria resistant to treatment
3. H. Pylori bacteria may help prevent some esophageal cancers
4. Scientists discover bacteria that can cause bone infections
5. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
6. Gene against bacterial attack unravelled
7. Predatory bacterial swarm uses rippling motion to reach prey
8. Bacteria manage perfume oil production from grass
9. Nature study demonstrates that bacterial clotting depends on clustering
10. Battling bacteria in the blood: Researchers tackle deadly infections
11. Shifts in soil bacterial populations linked to wetland restoration success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2014)... COLUMBIA, Mo. A family of proteins that promotes ... block the release of HIV and other viruses, University ... surprising finding that provides new insights into our understanding ... Ebola and other viruses," said Shan-Lu Liu, M.D., Ph.D., ... of Molecular Microbiology and Immunology. , The study was ...
(Date:8/25/2014)... reproduces by manipulating the behavior of ants emits ... brain of its natural target host, but not ... shows., The findings, which suggest that the fungus ... the molecular mechanisms underlying this phenomenon, according to ... to secrete chemicals that affect their environment," noted ...
(Date:8/25/2014)... 25, 2014 Riddell, the leader in football ... Research Institute (TGen), a leader in cutting-edge genomic ... University and its Sun Devil football program will ... to advance athlete concussion detection and treatment. , ... project will combine molecular information and head impact ...
Breaking Biology News(10 mins):MU researchers discover protein's ability to inhibit HIV release 2MU researchers discover protein's ability to inhibit HIV release 3Zombie ant fungi 'know' brains of their hosts 2Zombie ant fungi 'know' brains of their hosts 3Riddell, TGen team with ASU football to further genetic research into concussion detection 2Riddell, TGen team with ASU football to further genetic research into concussion detection 3
... won the American Geophysical Unions 2008 journalism awards: ... Excellence in Science JournalismNews for her article on the biggest ... shelf suspected to be a victim of global warming. ... daily newspaper in Montreal, Quebec, Canada. ...
... According to a report released today by the Wildlife ... Cambodias famed Tonle Sap region have staged remarkable comebacks, ... park rangers to provide 24-hour protection to breeding colonies. ... and egg collectors to protect and monitor the colonies, ...
... at North Carolina State University have pinpointed a small group ... to produce a hormone that is key to their development. ... production in plants affects both a plants growth and its ... assistant professor of genetics, and a team of geneticists and ...
Cached Biology News:AGU Journalism Awards won by Margaret Munro and Dr. Richard Smith 2NC State researchers identify genes key to hormone production in plants 2
(Date:8/26/2014)... 26, 2014   Lycera Corp ., a ... medicines to treat autoimmune disease and cancer based ... the appointment of Harinder Singh , Ph.D., ... Dr. Singh will lead the board,s efforts to ... ongoing research programs and pipeline of therapies targeting ...
(Date:8/26/2014)... Genedata, a leading provider of ... science research, today announced the Genedata Screener® ... in Asia, Europe, and North America during September ... leading research organizations will gather for annual User ... and upcoming challenges in all areas of screening. ...
(Date:8/26/2014)... , Aug. 26, 2014  That,s Nice LLC, a ... today announced the formation of a new dedicated team ... The expanded team will combine current and new staff ... That,s Nice. Guy Tiene ... lead the team. Tiene was previously Director of Marketing ...
(Date:8/26/2014)... Formedix, the leading provider of clinical ... Transform for MARVIN: the latest addition to its ... line. It was developed in collaboration with Formedix ... the EDC and Clinical Data Management system. , ... allowing instantaneous visualization of MARVIN eCRFs as they ...
Breaking Biology Technology:Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3Introducing Transform for MARVIN: Providing Further Flexibility for CROs and Sponsors in Partnership with XClinical 2
... in Physics from the Public University of Navarre and ... studied the behaviour and properties of nanometric-scale semiconductor crystals. ... Dr Echeverra to study the behaviour of semiconductor crystals ... hundred nanometres (a nanometre is a millionth part of ...
... 15 In a continual effort to alleviate the ... Nursing,s Future is hosting the Promise of Nursing ... scholarships to help ease the nursing shortage in Pennsylvania. ... in Philadelphia on Thursday, September 16, will support regional ...
... Sept. 14 Dendreon Corporation (Nasdaq: DNDN ) ... of North American commercial operations at Genentech, a wholly-owned member ... of Directors. "It,s been rewarding to serve ... in Dendreon,s history," said Mr. Clark. "Unfortunately, my job responsibilities ...
Cached Biology Technology:Ph.D. study of behavior of semiconductor crystals of size less than 100 nanometers 2Pennsylvania Partnerships Address Statewide Nursing Shortage 2Pennsylvania Partnerships Address Statewide Nursing Shortage 3Dendreon Announces Change in Board of Directors 2
... universal digital valve, just 8 mm in width. ... features in a single glass-reinforced, PBT (Polybutylene Terephthalate) ... in width. , Meets a range of pressure ... , Satisfies a 0.016 sccm leakage specification (0.2 ...
... The FilterMate is a compact, versatile system ... a 96- or 24-well microplates into a ... microplate liquid scintillation and gamma counter. The ... samples for applications such as cell proliferation, ...
... General description: Designed for use with ... CLS number is a new product number, ... If showing no availability yet, please order ... contact customer service for assistance. Comp Dim: ...
... G bind specifically to Fc regions of ... G conjugates are commonly used as affinity ... subtypes from serum, hybridoma ascites fluids, tissue ... reagents are also commonly used to capture ...
Biology Products: