Navigation Links
From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
Date:3/26/2012

Escherichia coli a bacteria considered the food safety bane of restaurateurs, grocers and consumers is a friend. Cornell University biomolecular engineers have learned to use E. coli to produce sugar-modified proteins for making pharmaceuticals cheaper and faster. (Nature Chemical Biology, March 25, 2012.)

Matthew DeLisa, Cornell associate professor of chemical and biomolecular engineering, and his research team, now have published a novel method for engineering human therapeutic glycoproteins simply and quickly by using E. coli bacteria as a platform. Their methods are now being developed and commercialized through a startup company, Glycobia Inc., which recently took up residence in Cornell's McGovern Family Center for Venture Development in the Life Sciences. While there are no firm plans yet, the professor hopes that within a year, testing this kind of pharmaceutical could be done at the Weill Cornell Medical College in Manhattan.

Glycoproteins are proteins that are modified at specific amino acid "acceptor" sites with complex carbohydrate structures, or oligosaccharides a basic human chemical reaction that's essential to life. That's why specifically designed, genetically engineered glycoproteins are so commonly used as drugs they bind to certain protein receptor sites and, for example, block cancer cells from multiplying. Among glycoproteins used to treat diseases today are monoclonal antibodies and interferons.

Current manufacturing methods rely mainly on costly, time-consuming mammalian culture cells, such as the Chinese Hamster Ovary (CHO) cell line. The process is also susceptible to viral contamination, further driving up production cost. In fact in 2009, another biopharmaceutical company temporarily shut down its plant after such a contamination occurred.

The Cornell research uses a method to assemble a synthetic pathway for the simple and quick production of a glycoprotein that for
'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Seafarers scourge provides hope for biofuel future
2. Disinfectants can make bacteria resistant to treatment
3. H. Pylori bacteria may help prevent some esophageal cancers
4. Scientists discover bacteria that can cause bone infections
5. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
6. Gene against bacterial attack unravelled
7. Predatory bacterial swarm uses rippling motion to reach prey
8. Bacteria manage perfume oil production from grass
9. Nature study demonstrates that bacterial clotting depends on clustering
10. Battling bacteria in the blood: Researchers tackle deadly infections
11. Shifts in soil bacterial populations linked to wetland restoration success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... of environmental scientists and engineers, led by Clemson ... three-year, $5.25 million grant from the U.S. Department ... to make a direct positive impact on South ... disposal of radioactive contaminants. , "Understanding the scientific ... with environmental aspects of nuclear technologies is imperative ...
(Date:9/30/2014)... German . ... foods in the world. Because they grow underground, people use ... smell of truffles is not only of interest to gourmets. ... of the Goethe University Frankfurt have discovered that the smell ... are trapped inside truffle fruiting bodies. , White truffles from ...
(Date:9/30/2014)... doctor to know what goes wrong with your muscles because ... know what "normal" actually is. That,s where a new research ... FASEB Journal comes in. In the report, ... of molecules that can help scientists "see" which genes are ... they found never-before-detected gene activity and that men have approximately ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2On the trail of the truffle flavor 2Scientists identify which genes are active in muscles of men and women 2
... in the December issue of Lancet Oncology challenges mainstream oncology ... as a major reason that cancer metastasizes or spreads to ... remarkable number of traits normally attributed to white blood cells ... nodes and distant organs and to form a new blood ...
... Current Biology, tsunami damage to coral reefs closest to ... spectacular, but surprisingly limited, particularly when compared to damage ... Less than 100 days after the tsunami of December ... University, the Wildlife Conservation Society-Indonesia Program, and Syiah Kuala ...
... University of Colorado at Boulder that can determine the ... within hours may help world health officials combat coming ... new technology by the Centers for Disease Control and ... determine the genetic make-up of types and subtypes of ...
Cached Biology News:New evidence supports century-old theory of cancer spread 2New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 2New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 3New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 4
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
(Date:10/1/2014)... Sept. 30, 2014 This report ... in US$ Million by the following Product ... Enzymes. Specific end-use segments also analyzed are ... The report provides separate comprehensive analytics ... Middle East, and Latin America. Annual estimates ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
(Date:9/30/2014)... September 30, 2014 Over the last ... due to rising R&D budgets and increased acceptance of ... growing pharmaceutical and biotechnology industries are also catalyzing the ... filtration market is expected to grow at a strong ... estimated to be worth $2,532.6 million by 2019. The ...
Breaking Biology Technology:Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5
... FluForecast® warning in April 7th, 2008, a year before ... company was able to state the likelihood of H1N1 ... which examines specific regions in virus genes which have ... below as published on the Web, stated that in ...
... 2009 and Host Call on Friday, May 1, 2009 EATONTOWN, ... ), a leader in the emerging field of biologic products ... ended March 31, 2009 financial results will be released Thursday, ... a conference call and webcast on Friday, May 1, 2009, ...
... CITY, China, April 24 Sinobiopharma, Inc. (OTC Bulletin ... highlights from the unaudited financial results for the nine month period ... , Sales revenue increased to ... US $1,170,677 in the corresponding period ended February 29, 2008. ...
Cached Biology Technology:Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 2Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 3Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 4Osteotech Announces First Quarter 2009 Earnings Release and Conference Call 2Sinobiopharma Reports a 41% Increase in Revenues From Unaudited Financial Results for the 9 Month Period Ended February 28, 2009 2
Recombinant Rat Leptin, Ultra Pure...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: