Navigation Links
From pre-gut cells to glory
Date:6/3/2011

PASADENA, Calif.For all animals, development begins with the embryo. It is here that uniform cells divide and diversify, and blueprints are laid for future structures, like skeletal and digestive systems. Although biologists have known for some time that signaling processesmessages that tell a cell to express certain genes so as to become certain parts of these structuresexist at this stage, there has not been a clear framework explanation of how it all comes together.

Now, a research team at the California Institute of Technology (Caltech) has outlined exactly how specific sets of cells in sea-urchin embryos differentiate to become the endoderm, the early domain of the embryo that eventually forms the gut. Their findings were reported in a paper entitled "A gene regulatory network controlling the embryonic specification of endoderm," published by the journal Nature online on May 29, in advance of the print version.

"If you only look at the genetic information of cells in an embryo, they all have the same genome and they all start from the single-cell zygote," says Isabelle S. Peter, a senior postdoctoral scholar at Caltech and coauthor of the study. "But then cells start to divide and, at some point, these cells are no longer identical in the genes that they express. We wanted to know how this process is achievedhow differences are established in cells in the right place and at the right time."

In order for undifferentiated cells to change their state and become a specific part of the body, the right genes need to be expressed, and the wrong ones repressed. The most important genes are regulatory genes, which control the expression of other genes, and form a gene regulatory network (GRN) that doles out differentiation instructions by turning genes on or off at specific times during embryonic development.

In the work described in the Nature paper, Peter and Eric H. Davidson, the Norman Chandler Professor of
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. NSF funds new Center for the Physics of Living Cells at Illinois
3. When cells go bad
4. The role of stem cells in renewing the cornea
5. Breast cancer cells recycle to escape death by hormonal therapy
6. Models of eel cells suggest electrifying possibilities
7. Scientists identify a molecule that coordinates the movement of cells
8. Form of Crohns disease traced to disabled gut cells
9. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
10. Researchers design artificial cells that could power medical implants
11. Stabilizing force for good communication between neurons and muscle cells found
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
From pre-gut cells to glory
(Date:9/18/2014)... the ultimate form of camouflage: you don,t just blend ... is not as uncommon as you might think. Kathryn ... explains that the larval life stages of many marine ... the anatomy that most creatures cannot make transparent. Feller ... shield each individual eye unit with an opaque pigment ...
(Date:9/17/2014)... Penn State,s Institute for the Arts and Humanities has ... Foundation for a two-year project, "The Boundaries of the ... The project will support a wide-ranging series of events ... and humanities. One involves artists and researchers who are ... and the idea of humanism, and the other involves ...
(Date:9/17/2014)... against disposable plastic shopping bags and their environmental impact ... passed the first statewide ban on the bags, and ... the plastic bag industry is not yielding without a ... Engineering News , the weekly newsmagazine of the American ... C&EN, reports that the anti-bag campaign logged its first ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Mellon Foundation awards grant for major project in the humanities and sciences 2
... NOVEMBER 16, 2009 Experts in soil science and representatives ... Congressional educational briefing, "The Essence of Earth and Wine: Terroir" ... House Office Building (Gold Room). Experts in ... -- how the balance of vineyard management and soil site ...
... mind sharing space with their kin but when they,re potted ... leaves, a study by McMaster University reveals. The research, ... Journal of Botany , suggests non-kin plants will not only ... out the competition above ground in the ongoing struggle for ...
... dioxide (TiO2) nanoparticles, found in everything from cosmetics to ... in mice, according to a comprehensive study conducted by ... TiO2 nanoparticles induced single- and double-strand DNA breaks and ... of which increase the risk for cancer. The UCLA ...
Cached Biology News:Soil experts to discuss terroir, the link between Earth, wine on Nov. 19 in DC 2Plants prefer their kin, but crowd out competition when sharing a pot with strangers 2Nanoparticles used in common household items caused genetic damage in mice 2Nanoparticles used in common household items caused genetic damage in mice 3
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... are undifferentiated biological cells that can differentiate into specialized ... stem cells. Stem cell therapy can be applied to ... system disease), nervous system diseases, damage or lesion of ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Human Albumin Industry Report 2014" report ... Albumin Industry Report 2014 is a professional and in-depth ... albumin industry. The report provides a basic ... industry chain structure. The human albumin market analysis is ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Leatherwood ... FM-4910 listed material, to stay competitive in the ... These high-performance materials ultimately impact product quality and ... and owner. , Established in 1980 in Lewisville, ... as many fabricators have left the business. Much ...
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
Breaking Biology Technology:Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3
... DNA polymerase , makes hot start simple and efficient , , ... , , , Jonathan Eads Frances Bai Ronda ... Stratagene , , , ... Taq , DNA polymerase , is ...
... ,,,, Stable reporter cell lines for signal transduction ... Li Xu Alan Greener Mary Buchanan ,John ... the PathDetect ,HLR-CREB, HLR-Elk1, and ... signal transduction pathways that converge at the transcription,factors CREB, ...
... minutes , Weiping Yang Matt C. ... Cloning Systems, Inc. , Stratagenes IsoDetect mouse monoclonal ... method for identifying mouse monoclonal antibody,isotypes in a ... self-contained assay,using colloidal gold-conjugated anti-mouse antibodies for isotype ...
Cached Biology Technology:Greater Amplification Specificity with New Hot Start PCR Enzyme 2Greater Amplification Specificity with New Hot Start PCR Enzyme 3Greater Amplification Specificity with New Hot Start PCR Enzyme 4Greater Amplification Specificity with New Hot Start PCR Enzyme 5Greater Amplification Specificity with New Hot Start PCR Enzyme 6Greater Amplification Specificity with New Hot Start PCR Enzyme 7Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 2Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 3Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 4Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 5Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 6Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 2Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 3Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 4Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 5