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From mild-mannered to killer plague
Date:8/29/2011

lost during its rapid evolution (somewhere between 1,500 and 20,000 years ago), and thereby potentially responsible for the Plague's virulence. Lathem's team developed this explanation because they could specify exactly which genes the sRNAs control.

First author Jovanka Koo, a postdoctoral fellow in Lathem's lab at Feinberg, noted, "An important lesson is that small changes can have big effects on sRNA functions. They can affect when an RNA is expressed or produced, the way that RNA folds, and the ability of that RNA to affect the regulated protein coding RNA." Over time, those small changes can become the difference between mild and deadly diseases.


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Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

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