Navigation Links
From mild-mannered to killer plague
Date:8/29/2011

CHICAGO In the evolutionary blink of an eye, a bacterium that causes mild stomach irritation evolved into a deadly assassin responsible for the most devastating pandemics in human history. How did the mild-mannered Yersinia pseudotuberculosis become Yersinia pestis, more commonly known as the Plague?

Now, scientists from Northwestern University Feinberg School of Medicine, with the use of new DNA sequencing techniques, offer long sought after evidence of how these two pathogens with virtually identical genetic matter could produce two such vastly different diseases. The Feinberg School team used the new DNA sequencing techniques to identify an unexpected source for these differences, which may help explain the Plague's rapid evolution.

The findings, to be published Aug. 29 in the journal Proceedings of the National Academy of Sciences, offer a glimpse into how the new technology might aid in the development of therapeutics to fight deadly diseases, including the Plague.

"Most people think of the Plague as a historic disease, but it's still a public health issue today, both in the human population and in animals," said Wyndham Lathem, lead author of the study and assistant professor of microbiology-immunology at Northwestern's Feinberg School. "It's extremely dangerous and highly virulent. Without treatment, it can take as little as three to five days from infection to death."

Globally, the World Health Organization reports 1,000 to 3,000 cases of Plague every year, and Y. pestis exists on every continent except Antarctica. The United States Department of Homeland Security classifies Y. pestis as a Category A biological agent, a group that also includes anthrax, smallpox and Ebola.

The Plague's ancestor, Y. pseudotuberculosis, still exists and infects humans, but it causes a mild gastrointestinal disease and most people don't show symptoms.

Lathem and colleagues have discov
'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Paternity testing helps fill in family tree for Puget Sounds killer whales
2. How killer immune cells avoid killing themselves
3. Scientists track evolution and spread of deadly fungus, one of the worlds major killers
4. NOAA scientists find killer whales in Antarctic waters prefer weddell seals over other prey
5. Natural (born) killers: What do they really do?
6. Killer paper for next-generation food packaging
7. Monitoring killer mice from space
8. Killer paper for next-generation food packaging
9. Virus killer gets supercharged
10. Battling a bat killer
11. Ants found to use multiple antibiotics as weed killers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... has demonstrated that transplantation of mesenchymal stem cells can ... mouse models of Alzheimer,s disease (AD) and improve tissue ... Few studies are reported on the therapeutic effect of ... and on the effect on oxidative injury and neurogenesis ... and her team, School of Life Sciences, Tsinghua University, ...
(Date:7/11/2014)... study the proteins that let nerve cells send out ... upon a biological tactic that may offer a new ... safe and environmentally responsible way. , Their findingthat ... species and harmless for a closely related onesuggests that ... harming beneficial species like bees. A summary of the ...
(Date:7/10/2014)... 30, 2014  Aware, Inc. (NASDAQ: AWRE ... previously announced on June 26, 2014 that its Board ... $1.75 per share, or approximately $40 million in total.  ... 2014 and a payment date of July 24, 2014.  ... had set an ex-dividend date for this special cash ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2
... Everyone wants to live in the nicest possible house, ... at Tufts University,s School of Arts and Sciences and ... locate new and improved housing using previously unknown social ... experiments and computer models to uncover some surprising new ...
... Here,s another reason to kick the soda habit. New ... ( http://www.fasebj.org ) shows that high levels of phosphates ... than once thought. That,s because researchers found that the ... phosphate levels may also increase the prevalence and severity ...
... 23, 2010) Moffitt Cancer Center announces steadily growing ... for selecting chemotherapy for Non Small Lung Cancer patients. ... with lung cancer. The ERCC1 Analysis measures ERCC1 ... The correlation between ERCC1 levels and therapy ...
Cached Biology News:Social networking helps hermit crabs find homes 2Social networking helps hermit crabs find homes 3Phosphorous in sodas and processed foods accelerates signs of aging say Harvard scientists 2Moffitt Cancer Center: Growing interest in prognostic test for non-small cell lung cancer 2
(Date:7/11/2014)... 11, 2014 Research and Markets  has ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... http://photos.prnewswire.com/prnh/20130307/600769 ... (either DNA or RNA) into cells. This technology helps ... cells and protein metabolism by affecting the nuclear genes. ...
(Date:7/11/2014)... , July 11, 2014 /CNW/ - Sunovion Pharmaceuticals ... APTIOM TM (eslicarbazepine acetate) for use as a ... in patients with epilepsy who are not satisfactorily controlled ... for use in patients under 18 years of age. ... common neurological disorders and according to Epilepsy Canada, it ...
(Date:7/10/2014)... July 10, 2014 Women in ... access to an additional family planning option. Sayana® ... contraception at all levels of the health system ... of a widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone ... Faso is the first of four African countries ...
(Date:7/10/2014)... Cleveland, Ohio (PRWEB) July 10, 2014 ... in ion channel-expressing cell lines, and the gap that ... new cells that expand its industry-leading portfolio of validated ... focuses on ion channel-expressing cell lines, as ion channels ... able to control this activity creates the potential to ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Corporation is,pleased to announce it has obtained US FDA ... C-QUR Edge(TM) V-Patch and C-QUR Lite(TM),V-Patch., These new ... and,reinforcement of soft tissue, including hernia repair -- a ... each year. This novel,technology combines Atrium,s ProLite Ultra(TM) polypropylene ...
... ENMD-2076, ROCKVILLE, Md., May 8 ... developing therapeutics for,the treatment of cancer and ... has joined the University of Colorado Cancer,Center ... ENMD-2076 in advanced cancer,patients. Dr. Geoffrey Shapiro, ...
... May 7, 2008 / b3c newswire / – ... entered into a joint agreement to supply customers ... complex structures. , Under the agreement, CRELUX and ... crystal-grade protein kinase portfolio, optimized and quality-controlled for ...
Cached Biology Technology:Atrium Medical Receives FDA Approval for its Novel C-QUR Lite(TM) V-Patch and C-QUR Edge(TM) V-Patch 2Dana-Farber Cancer Institute Commences Phase 1 Trial With EntreMed's Selective Kinase Inhibitor 2Dana-Farber Cancer Institute Commences Phase 1 Trial With EntreMed's Selective Kinase Inhibitor 3CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform 2CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform 3