Navigation Links
From heterogeneous patient measurements towards earlier diagnosis in Alzheimer's disease
Date:12/15/2011

European PredictAD project, lead by Principal Scientist Jyrki Ltjnen from VTT Technical Research Centre of Finland, has developed a decision support tool for objective diagnostics of Alzheimer's disease. The tool compares measurements of a patient to measurements of other persons available in large databases and provides a simple index about the severity of the disease. The project has shown that the tool improves the accuracy of diagnosis and clinicians' confidence about their decision, making earlier diagnosis possible.

Dementia has been recently identified as a health priority both in Europe and in the USA. Alzheimer's disease, the most common cause of dementia, alone accounts for costs equivalent to about 1% of the gross domestic product (GDP) of the whole world and the number of persons affected will double in the next 20 years. Early diagnosis plays a key role in solving the problem because treatments of this irreversible disease should be started at an early phase to be efficient.

The current guidelines for the diagnostics of Alzheimer's disease emphasize the role of various biomarkers. These biomarkers include measures from magnetic resonance imaging (MRI), positron emission tomography (PET), biomarkers from cerebrospinal fluid (CSF) and genetic biomarkers in addition to evidenced memory impairment. No single patient measure provides enough information for diagnostics. Currently, clinicians make the final diagnosis by combining heterogeneous measurements with information from interviews of the patient and relatives. This process involves subjective reasoning and requires strong expertise from the clinicians.

Modern hospitals have huge data reserves containing information that nobody has extracted. For example, the hippocampus is a central structure for memory and affected in Alzheimer's disease and brain MRI image databases contain information about the normal variability of the hippocampus in healthy and disased persons. This information can be utilised in diagnostics by systematic mathematical modelling.

PredictAD has designed a totally novel approach for measuring objectively the state of the patient. This decision support system, developed in close collaboration with clinicians, compares patient measurements with measurements of other persons in large databases and provides at the end an index and graphical representation reflecting the state of the patient. The index is a barometer of the disease making grounds for decisions more solid and objective. The graphical representation provides a clinician in glance information about the status of her/his patient compared with hundreds of other persons, some having the disease and some being healthy.

"The PredictAD tool provides a new option to support decision making by providing objective information about the patient", says Prof. Hilkka Soininen from the University of Eastern Finland, leading the clinical validation of the project.

Prof. Gunhild Waldemar from Copenhagen University Hospital, Rigshospitalet emphasizes the importance of the Alzheimer's disease research: "Successful, early diagnostics combined with the novel drugs under development and early psychosocial care may delay the institutionalization of patients, reducing suffering and the costs to the society. It has been calculated that delaying the onset of the disease by five years would halve all costs of Alzheimer's disease and delaying onset and progression by only one year would reduce the number of Alzheimer's cases by about 10%."


'/>"/>

Contact: Jyrki Ltjnen
jyrki.lotjonen@vtt.fi
358-207-223-378
VTT Technical Research Centre of Finland
Source:Eurekalert

Related biology news :

1. When standard treatment fails: Jefferson to start unique immunotherapy for brain tumor patients
2. Addition of trastuzumab may potentially equalize disease-free survival outcomes among obese and normal-weight patients
3. How will patients, families and doctors handle the coming flood of personalized genetic data?
4. Yale researchers develop a way to monitor engineered blood vessels as they grow in patients
5. IVC filters: Society of Interventional Radiology leads in patient care, safety, research
6. Restricted calorie diet improves heart function in obese patients with diabetes
7. New service brings power of genomics to patient care
8. New hope for young leukemia patients?
9. Low vitamin C levels may raise heart failure patients risk
10. UHN, University of Toronto launch Techna innovation hub to get health technologies to patients faster
11. Experimental drug suppresses rebound of hepatitis C virus in liver transplant patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
Breaking Biology Technology: