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From heterogeneous patient measurements towards earlier diagnosis in Alzheimer's disease
Date:12/15/2011

European PredictAD project, lead by Principal Scientist Jyrki Ltjnen from VTT Technical Research Centre of Finland, has developed a decision support tool for objective diagnostics of Alzheimer's disease. The tool compares measurements of a patient to measurements of other persons available in large databases and provides a simple index about the severity of the disease. The project has shown that the tool improves the accuracy of diagnosis and clinicians' confidence about their decision, making earlier diagnosis possible.

Dementia has been recently identified as a health priority both in Europe and in the USA. Alzheimer's disease, the most common cause of dementia, alone accounts for costs equivalent to about 1% of the gross domestic product (GDP) of the whole world and the number of persons affected will double in the next 20 years. Early diagnosis plays a key role in solving the problem because treatments of this irreversible disease should be started at an early phase to be efficient.

The current guidelines for the diagnostics of Alzheimer's disease emphasize the role of various biomarkers. These biomarkers include measures from magnetic resonance imaging (MRI), positron emission tomography (PET), biomarkers from cerebrospinal fluid (CSF) and genetic biomarkers in addition to evidenced memory impairment. No single patient measure provides enough information for diagnostics. Currently, clinicians make the final diagnosis by combining heterogeneous measurements with information from interviews of the patient and relatives. This process involves subjective reasoning and requires strong expertise from the clinicians.

Modern hospitals have huge data reserves containing information that nobody has extracted. For example, the hippocampus is a central structure for memory and affected in Alzheimer's disease and brain MRI image databases contain information about the normal variability of the hippocampus in healthy and disased persons.
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Contact: Jyrki Ltjnen
jyrki.lotjonen@vtt.fi
358-207-223-378
VTT Technical Research Centre of Finland
Source:Eurekalert

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