Navigation Links
From fruit fly wings to heart failure -- why Not(ch)?
Date:12/10/2009

Monterotondo, 10 December 2009 - Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, are the first to prove that this signalling pathway targets heart muscle cells and thus reveal its crucial role in heart development and repair.

The Notch pathway is a molecular mechanism through which cells communicate with each other. Scientists in Nadia Rosenthal's group at EMBL used sophisticated genetic mouse models to uncover critical roles for this pathway in heart muscle cells. When they inactivated Notch specifically in the heart muscle precursor cells of early mouse embryos, the scientists discovered that the mice developed heart defects. Curiously, increasing Notch signalling in the heart muscle cells of older embryos had the same detrimental effect, uncovering different requirements for Notch as development proceeds.

"The cardiac malformations we observed are characteristic of Alagille syndrome, a human congenital disorder," said first author Paschalis Kratsios. "Therefore, our findings could help to explain the cardiac symptoms associated with Alagille syndrome and related forms of congenital heart disease."

Intriguingly, the scientists were able to improve the cardiac function and survival rate of adult mice that had suffered heart attacks by re-activating Notch, suggesting new therapeutic approaches to help the heart recover from damage.

"Overall, these results highlight the importance of timing and context in biological communication mechanisms" Nadia Rosenthal concludes: "Our findings also lend support to the notion that, in certain situations, redeployment of embryonic signalling pathways could prove beneficial for tissue regeneration in the adult."


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Related biology news :

1. Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies
2. Laser etching safe alternative for labeling grapefruit
3. UM scientists create fruit fly model to help unravel genetics of human diabetes
4. Scientists of the UGR obtain a bioinsecticide to control the Mediterranean fruit fly
5. GSU professor develops new method to help keep fruit, vegetables and flowers fresh
6. Fruit fly pest identified in wine grapes
7. Pesky fruit flies learn from experienced females: Study
8. Carbon nanoparticles toxic to adult fruit flies but benign to young
9. Warming climate threatens California fruit and nut production
10. Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection
11. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
From fruit fly wings to heart failure -- why Not(ch)?
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... March 21, 2017 Optimove , ... by retailers such as 1-800-Flowers and AdoreMe, today ... Recommendations and Replenishment. Using Optimove,s machine learning algorithms, ... product and replenishment recommendations to their customers based ... predictions of customer intent drawn from a complex ...
(Date:3/16/2017)... Germany , March 16, 2017 CeBIT 2017 - Against identity ... Continue Reading ... Used combined in one project, multi-biometric solutions provide ... Used ... Systems) ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... and RESEARCH TRIANGLE PARK, N.C. ... (NASDAQ: UTHR ) today announced that its ... $250 million of the company,s common stock. This program ... December 31, 2017. Purchases may be made in the ... transactions from time to time as determined by United ...
(Date:4/27/2017)... ... April 27, 2017 , ... Arrowhead ... ( http://www.paintherapeuticsummit.com ) is coming to San Diego, CA on September 27-28, 2017. ... learn about the latest advances in the treatment of various types of pain. ...
(Date:4/27/2017)... , ... April 27, 2017 , ... ... 2017 Borlaug CAST Communication Award goes to Jayson Lusk, a consummate communicator who ... of media to advocate for science, as he explains how innovation and growth ...
(Date:4/26/2017)... USA (PRWEB) , ... April 26, 2017 , ... ... on FDA’s GMP expectations for phase I clinical trials comes to Tampa, San ... various biotechnology and pharma professionals representing FDA regulated organizations such as Pfizer Inc., ...
Breaking Biology Technology: