Navigation Links
From eons to seconds, proteins exploit the same forces
Date:8/13/2014

p>"If the selection temperature is too high in the sequence space, the search will give every possible sequence. But most of those wouldn't fold right. The low selection temperature tells us how important folding has been for evolution."

"If the selection temperature and the folding temperature were the same, it would tell us that proteins merely have to be thermodynamically stable," Wolynes said. "But when the selection temperature is lower than the folding temperature, the landscape actually has to be funneled."

"If proteins evolved to search for funnel-like sequences, the signature of this evolution will be seen projected on the sequences that we observe," Onuchic said. The close match between the sequence data and energetic structure analyses clearly show such a signature, he said, "and the importance of that is enormous."

"Basically, we now have two completely different sources of information, genomic and physical, that tell us how protein folding works," he said. Knowing how evolution did it should make it much faster for people to design proteins "because we can make a change in sequence and test its effect on folding very quickly," he said.

"Even if you don't fully solve a specific design problem, you can narrow it down to where experiments become much more practical," Onuchic said.

"Each of these methods has proved very useful and powerful when used in isolation, and we are just starting to learn what can be achieved when they are used together," said Nicholas Schafer, a Rice postdoctoral researcher and co-author. "I'm excited to be participating in what I think will be an explosion of research and applications centered around these kinds of ideas and techniques."

Faruck Morcos is the paper's lead author and Ryan Cheng is a co-author. Both are postdoctoral researchers at Rice. Onuchic is Rice's Harry C. and Olga K. Wiess Professor of Physics and Astronomy and co-director of the CTBP based at Rice's Bio
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. New method provides researchers with efficient tool for tagging proteins
2. Scientists map one of most important proteins in life -- and cancer
3. National Xenopus resource at the MBL innovates new way to study proteins
4. Cell membrane proteins give up their secrets
5. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
6. Cellular defence against fatal associations between proteins and DNA
7. Long non-coding RNAs can encode proteins after all
8. Architecture of signaling proteins enhances knowledge of key receptors
9. Family of proteins plays key role in cellular pump dynamics
10. The transmission of information via proteins could revolutionize drug discovery
11. New technique tracks proteins in single HIV particle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
From eons to seconds, proteins exploit the same forces
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... entomologists are set to meet next week at the ... as the North Central Branch of the Entomological Society ... topics will include public health/bed bug entomology, biocontrol of ... and Sontrol tactics, soybean aphid management, and insect biodiversity ...
... -- It,s a cloak that surpasses all others: a ... the way bacteria and other cells are imaged. ... State University, and his research team are wrapping bacteria ... under electron microscopes. Berry,s method creates a carbon cloak ...
... , This release is available in Spanish ... grass breeder has rediscovered a forage grass that seems just ... of an unusual forage grass led Michael Casler, an Agricultural ... Research Center in Madison, Wis., to identify the grass as ...
Cached Biology News:All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 2All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 3Dairy farmer finds unusual forage grass 2
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
(Date:12/24/2014)... 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... no yellow tape or chalk outlines of a body, but ... want remedies, said a lawyer who spoke at the ... a partner with Michael Best & Friedrich , said ... or disgruntled employees can benefit from learning to work with ...
... a warning for chief information officers: By 2007, 80 percent ... executives. The CEO of Paragon Development Systems , an ... to stay involved with the business side of their companies ... change in a really short period of time," he said. ...
... If, five years ago, you asked a group of ... have said storage capacity, security or bandwidth. , ,Today, ... spate of securities legislation, highlighted by Congress's passage of ... has come to be called. SOX, which was passed ...
Cached Biology Technology:After a successful attack on your computer systems, then what? 2After a successful attack on your computer systems, then what? 3IT outsourcing remains on the horizon as companies focus on core business 2IT outsourcing remains on the horizon as companies focus on core business 3With Sarbanes-Oxley, compliance takes center stage for CIOs 2With Sarbanes-Oxley, compliance takes center stage for CIOs 3
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
RABBIT ANTI GLYCINE...
Request Info...
Biology Products: