Navigation Links
From eons to seconds, proteins exploit the same forces
Date:8/13/2014

heories developed by Onuchic and Wolynes nearly two decades ago already suggested this connection between evolution and physics. Proteins that start as linear chains of amino acids programmed by genes fold into their three-dimensional native states in the blink of an eye because they have evolved to obey the principle of minimal frustration. According to this principle, the folding process is guided by interactions found in the final, stable form.

Wolynes used this fundamental law to conceptualize folding in a new way. The top of his folding funnel represents all of the possible ways a protein can fold. As individual stages of the protein come together, the number of possibilities decreases and the funnel narrows and eventually reaches its functional native state.

A funnel's rugged landscape is different for every protein. It shows smooth slopes as well as outcroppings where parts of a protein may pause while others catch up, and also traps that could cause a protein to misfold.

"The funnel shows that the protein tries things that are mostly positive rather than wasting time with dead ends," Wolynes said. "That turns out to resolve what was called Levinthal's paradox." The paradox said even a relatively short protein of 100 acids, or residues, that tries to fold in every possible way would take longer than the age of the universe to complete the process.

That may be true for random sequences, but clearly not for evolved proteins, or we wouldn't be here. "A random sequence would go down a wrong path and have to undo it, go down another wrong path, and have to undo it," said Wolynes, who in his original paper compared the process to a drunken golfer wandering aimlessly around a golf course. "There would be no overall guidance to the right solution."

So the funnel is a useful map of how functional proteins reach their destinations. "The only way to explain the funnel's existence is to say that sequences are not random, b
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. New method provides researchers with efficient tool for tagging proteins
2. Scientists map one of most important proteins in life -- and cancer
3. National Xenopus resource at the MBL innovates new way to study proteins
4. Cell membrane proteins give up their secrets
5. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
6. Cellular defence against fatal associations between proteins and DNA
7. Long non-coding RNAs can encode proteins after all
8. Architecture of signaling proteins enhances knowledge of key receptors
9. Family of proteins plays key role in cellular pump dynamics
10. The transmission of information via proteins could revolutionize drug discovery
11. New technique tracks proteins in single HIV particle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
From eons to seconds, proteins exploit the same forces
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics ... of human interface solutions, today announced collaboration with ... on Windows 10. Microsoft leveraged Synaptics, deep expertise ... operating system. Through stringent testing, ... fully certified with Microsoft,s Precision TouchPad (PTP) specification ...
(Date:8/5/2015)... 5, 2015 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... facial recognition is forecast to reach US$ 2,671.8 Mn ... for surveillance systems by civil and government agencies. This ... and terrorist activities across the globe that would elevate ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... bumble bees are at risk, other bee species in ... despite expanding human populations and changing land use. Led ... from the American Museum of Natural History and nine ... at protecting native bee species and the important pollinator ...
... brain adds new cells during puberty to help navigate the ... report in the current issue of the Proceedings of ... think the brain cells you,re born with are all you ... in adults, conventional wisdom held that such growth was limited ...
... an additional 100.000 Euros in financial support , ... the financial support through the execution of the business ... the Building Global Innovators & continued financial support by ... Building Global Innovators Venture Competition. The seamless low-cost vehicle-based ...
Cached Biology News:New research confirms plight of bumble bees, persistence of other bees in Northeast 2Brain adds cells in puberty to navigate adult world 2Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 2Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 3Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 4
(Date:8/27/2015)... ... August 27, 2015 , ... ... needs and expertly narrows down the product choices to a manageable shortlist of ... down the list to models that fit best with the customer’s industry and ...
(Date:8/26/2015)...  Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... for the detection of foodborne pathogens, today announced that ... & Company Emerging Growth Conference on September 2 at ... New York Marriott Marquis. A live ... investor relations section of Roka Bioscience,s website at ...
(Date:8/26/2015)... 26, 2015 Israel Proves Its Place in ... st place  Wayerz comes in 5 th ... by venture capital fund JVP, with Chinese consulting firm ... China , Israel , ... Impressive achievement for the Israeli representatives in the final round ...
(Date:8/26/2015)... ... August 26, 2015 , ... The 2015 Epigenomics & ... stem cell technology start-up company Asymmetrex to share the first report on ... a new biomarker for counting adult tissue stem cells. , With a name like ...
Breaking Biology Technology:METTLER TOLEDO Updates Online Scale Selection Tool 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... No Child Should Die of Diabetes, BRUSSELS, October ... it is bringing together key opinion,leaders to push for ... diabetes in developing countries without access to care., ... in the,Developing World, will be held on Saturday, October ...
... Therapeutics is,presenting new data today representing an ... to enhance outcomes in patients,suffering from lower ... "Local Catheter-Directed Elastase Therapy: A Novel,Approach to ... at the 20th,annual Transcatheter Cardiovascular Therapeutics (TCT) ...
... risk of basal,cell carcinoma, and are integrated into ... Oct. 13 Scientists at,deCODE genetics (Nasdaq: ... of two single-letter variations in the human genome ... the most common cancer among,people of European ancestry. ...
Cached Biology Technology:International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 2International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 3Proteon Therapeutics to Present New Data on PRT-201 at Transcatheter Cardiovascular Therapeutics (TCT) Annual Symposium in Washington, D.C., October 13, 2008 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 3deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 4
... detection of apoptosis and mitochondrial membrane potential. ... early indication of the initiation of cellular ... a collapse in the electrochemical gradient across ... change in the membrane potential (YD). Loss ...
... CYCLES. An assay kit designed to detect ... PARP is an enzyme implicated in DNA ... is cleaved by caspase-3. Cleavage of PARP ... kDa is a hallmark of apoptosis. Each ...
... the DH-2000, but comes with a shutter (controlled ... 5 Hz) The DH-2000 Deuterium ... of deuterium and tungsten halogen light sources in ... produces a powerful, stable output from 215-200 nm. ...
... The MSD Security ChemStation ... GC/MS software application for ... quantification, library searching and ... aspects of data security, ...
Biology Products: