Navigation Links
From bark to bedside: Study looks at canine cancer genes, human health impact
Date:6/21/2010

EAST LANSING, Mich. Michigan State University veterinarians are taking part in a two-year, $5.3 million project to analyze five cancers in dogs, research that could offer new insight into canine cancer genes and their potential impact on the human form of the disease.

The Canine Hereditary Cancer Consortium an alliance of veterinarians, scientists, clinicians, nonprofit institutions, universities and industry members will focus on purebred dogs, who offer a window into cancer genetics not available with other species, said Barbara Kitchell, director of MSU's Center for Comparative Oncology. She also is a member of the consortium's executive steering committee.

"Because purebred dogs have been selected to have specific physical and behavioral traits, their background genetics, within breeds, are very similar," Kitchell said. "With that 'background noise' suppressed, cancer genes are made more obvious."

The research partnership, entitled From Bark to Bedside, is led by the Van Andel Research Institute in Grand Rapids and the Translational Genomics Research Institute in Phoenix. Participating research teams are MSU, University of Pennsylvania and Colorado State University, as well as the National Cancer Institute.

As part of the group's research, MSU's Vilma Yuzbasiyan-Gurkan, a professor of microbiology and molecular genetics and small animal clinical sciences, specifically is looking at histiocytic sarcomas, which are malignant, soft-tissue tumors that arise from cells in the immune system.

If the tumor is removed before cancer cells spread, the prognosis is good. Once the cancer spreads, most dogs live just a few weeks. The dogs most often affected by this type of cancer are Bernese mountain dogs.

Yuzbasiyan-Gurkan and her team, which includes Matti Kiupel of pathobiology and diagnostic investigations, will rely on a DNA and tumor tissue repository they set up at MSU in 2006 to analyze the gene makeup of Bernese mountain dogs and search for cancer triggers. The MSU repository was established with grant support from the Berner-Garde Foundation and contributions from the Bernese Mountain Dog Club of America.

"We established the repository in anticipation of genomic technology developing to a point where it would be affordable for use with dogs," she said. "The timing is now right; this partnership brings the technology and computing power that are significant components of this task."

The project also aims to identify critical pathways that can be targeted by drugs, Kitchell said.

"For example, there may be a genetic change in a tumor that turns on a growth-promoting signal," she said. "We may discover from the arsenal of drugs and chemicals available to us that we can turn off that gene, allowing us to custom-tailor therapies."

There also are potential human benefits in the project, especially where a type of cancer is common in a particular breed of dog but uncommon in people. Because such large numbers are needed to get reliable findings, advances in human treatment are limited by the small number of people affected.

"With purebred dogs, you not only have a larger population with a particular cancer, but, because of these dogs' reduced genetic complexity, there is a better chance of identifying the responsible gene," Yuzbasiyan-Gurkan said. "It's a win-win situation for the dogs and people."

The other canine cancers being analyzed are non-Hodgkin's lymphoma, oral melanoma, osteosarcoma and hemangiosarcoma. The project is funded by a $4.3 million grant from the National Cancer Institute and $500,000 donations from both Pet Smart and Hill's Pet Nutrition.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Related biology news :

1. LSU professor uses volcanic emissions to study Earths atmospheric past
2. Robot submarine patrols Lake Michigan for climate-change study
3. New study documents use of hormone progesterone in simple microscopic aquatic animals
4. WHOI joins consortium to study, minimize effects of Gulf Oil spill
5. Study of severe asthma using CT scans
6. Study shows adding UV light helps form Missing G of RNA building blocks
7. Suspended animation protects against lethal hypothermia, study shows
8. UAB study confirms link between depression, abdominal obesity
9. UMCES Horn Point Laboratory scientists to study oil spill effects in Gulf of Mexico
10. CoLucid Pharmaceuticals, Inc. announces study data documenting oral efficacy of lasmiditan (COL-144), a selective 5-HT1F receptor agonist, in the treatment of acute migraine attacks
11. University of Washington institute to get as much as $100 million to study atmosphere, ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
(Date:1/19/2017)... , Jan. 19, 2017 ... user experience and security for consumer electronics, and ... payment processing systems and cybersecurity solutions, today announced ... enterprises and financial institutions worldwide to bolster security ... the end-to-end secure user authentication platforms they offer, ...
(Date:1/18/2017)... Minn. , Jan. 18, 2017 ... technology company that supports the entire spectrum of ... has been another record-breaking year for the organization ... market interest in MedNet,s eClinical products and services. ... the tremendous marketplace success of iMedNet ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... PHOENIX and NEW YORK ... announced the near completion of their $7M Series B ... on top of the $3.5M led by Mesa Verde ... of 2016.  These resources will be directed towards further ... Test, PCDx, a comprehensive genomic profiling test and expanding ...
(Date:2/15/2017)... ... February 15, 2017 , ... Executive search firm, ... Officer with GenePeeks. Matt is a veteran life sciences and molecular diagnostics ... company focused on identifying inherited disease risk in future generations. In his new ...
(Date:2/15/2017)... FRANCISCO , 15. Februar 2017  Trianni, ... Janssen Biotech, Inc. (Janssen) eine Lizenzvereinbarung über die ... ihrer Klasse führenden Plattform für die Entdeckung monoklonaler ... durch ihr neuartiges chimäres Gensegmentdesign aus, das ... an humanen Antikörpern bietet und das für die ...
(Date:2/15/2017)... 15, 2017  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the fourth quarter and full year ended December ... year for Vanda as we continued to demonstrate ... long-term exclusivity for Fanapt," said Mihael H. Polymeropoulos, ... emerging pipeline with important 2017 milestones underscores Vanda,s ...
Breaking Biology Technology: