Navigation Links
Friendly to a fault, yet tense: Personality traits traced in brain
Date:3/20/2012

A personality profile marked by overly gregarious yet anxious behavior is rooted in abnormal development of a circuit hub buried deep in the front center of the brain, say scientists at the National Institutes of Health. They used three different types of brain imaging to pinpoint the suspect brain area in people with Williams syndrome, a rare genetic disorder characterized by these behaviors. Matching the scans to scores on a personality rating scale revealed that the more an individual with Williams syndrome showed these personality/temperament traits, the more abnormalities there were in the brain structure, called the insula.

"Scans of the brain's tissue composition, wiring, and activity produced converging evidence of genetically-caused abnormalities in the structure and function of the front part of the insula and in its connectivity to other brain areas in the circuit," explained Karen Berman, M.D., of the NIH's National Institute of Mental Health (NIMH).

Berman, Drs. Mbemda Jabbi, Shane Kippenham, and colleagues, report on their imaging study in Williams syndrome online in the journal Proceedings of the National Academy of Sciences.

"This line of research offers insight into how genes help to shape brain circuitry that regulates complex behaviors such as the way a person responds to others and thus holds promise for unraveling brain mechanisms in other disorders of social behavior," said NIMH Director Thomas R. Insel, M.D.

Williams syndrome is caused by the deletion of some 28 genes, many involved in brain development and behavior, in a particular section of chromosome 7. Among deficits characteristic of the syndrome are a lack of visual-spatial ability such as is required to assemble a puzzle and a tendency to be overly-friendly with people, while overly anxious about non-social matters, such as spiders or heights. Many people with the disorder are also mentally challenged and learning disabled, but some have normal IQs.

Previous imaging studies by the NIMH researchers found abnormal tracts of the neuronal fibers that conduct long-distance communications between brain regions -- likely resulting from neurons migrating to the wrong destinations during early development.

Evidence suggests that genes influence our temperament and the development of mental disorders via effects on brain circuits that regulate behavior. Yet direct demonstration of this in humans has proven elusive. Since the genetic basis of Williams syndrome is well known, it offers a unique opportunity to explore such effects with neuroimaging, reasoned the researchers.

Although the insula had not previously been studied in such detail in the disorder, it was known to be related to brain circuitry and certain behaviors, such as empathy, which is also highly prominent in the disorder. Berman and colleagues hypothesized that the insula's anatomy, function and connectivity would predict patients' scores for Williams syndrome-associated traits on personality rating scales. Fourteen intellectually normal Williams syndrome participants and 23 healthy controls participated in the study.

Magnetic resonance imaging (MRI) revealed that patients had decreased gray matter the brain's working tissue in the bottom front of the insula, which integrates mood and thinking. By contrast, they had increased gray matter in the top front part of the insula, which has been linked to social/emotional processes.

Diffusion tensor imaging, which by detecting the flow of water in nerve fibers can identify and measure the connections between brain areas, showed reduced white matter the brain's long-distance wiring between thinking and emotion hubs.

Tracking radioactively-tagged water in order to measure brain blood flow at rest, via positron emission tomography (PET), exposed activity aberrations consistent with the MRI abnormalities. The PET scans also revealed altered functional coupling between the front of the insula and key structures involved in thinking, mood and fear processing. These structural and functional abnormalities in the front of the insula correlated with the Williams syndrome personality profile.

"Our findings illustrate how brain systems translate genetic vulnerability into behavioral traits" explained Berman.


'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Related biology news :

1. MU scientists go green with gold, distribute environmentally friendly nanoparticles
2. Queens scientists discover eco-friendly wood dissolution
3. Some aspects of birding not always environmentally friendly, professor says
4. In search of wildlife-friendly biofuels
5. Ants are friendly to some trees, but not others
6. Pumping up the heat for a climate-friendly future
7. Innovotech receives funding to advance environmentally friendly agricultural crop protection product
8. NTU gets GreenLite for Singapores first truly eco-friendly bus
9. Mother Nature to provide an environmentally friendly method for reducing mosquitoes
10. Scientists develop sustainable, environmentally friendly potting medium
11. New user-friendly resource connects human genes to biological functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Friendly to a fault, yet tense: Personality traits traced in brain
(Date:2/8/2017)... LONDON , Feb. 7, 2017 Report ... $12.5 billion by 2021 from $8.3 billion in 2016 ... from 2016 to 2021. Report Includes - An ... of global market trends, with data from 2015 and ... through 2021. - Segmentation of the market on the ...
(Date:2/3/2017)... ANTONIO , Feb. 3, 2017  Texas Biomedical Research ... Dr. Larry Schlesinger as the Institute,s new ... Texas Biomed effective May 31, 2017. He is currently the ... Director of the Center for Microbial Interface Biology at Ohio ... Schlesinger as the new President and CEO of Texas Biomed," ...
(Date:2/1/2017)... IDTechEx Research, a leading provider of independent market research, business ... new report, Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027 ... ... Revenues of ... for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine vision, force sensing ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... ... February 20, 2017 , ... USARAD ... company announces at HIMSS 2017 Annual Conference (Orlando, FL) a world-wide distribution ... a global cloud-based sharing and collaboration platform as part of the Siemens ...
(Date:2/20/2017)...  At the 2017 Health Information Management Systems ... , IBM (NYSE: IBM ) today introduced ... President and CEO Ginni Rometty will ... 8:30-10 am ET, broadcast live on www.ibm.com ... examine the advent of the Cognitive Era and ...
(Date:2/18/2017)... ... February 17, 2017 , ... The BMT Tandem Meetings ... for International Blood & Marrow Transplant Research (CIBMTR) will take place Feb. 22-26, ... The combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical research professionals, nurses, ...
(Date:2/17/2017)... Feb. 17, 2017  BioGenex, a global leader ... of a novel system for quantitative immunohistochemistry (IHC). ... University of Rochester (NY, USA) and Konica-Minolta Inc. ... system is able to accurately quantify the expression ... epidermal growth factor receptor-2) in clinical samples. Quantitative ...
Breaking Biology Technology: