Over time, this can lead to the accumulation of mutations which speed up ageing and destroy the skin's supportive fibres, collagen and elastin, causing wrinkles. Recent studies strongly suggest the damage caused by reactive oxygen species may also initiate and exacerbate the development of skin cancers.
Antioxidants in our diets from green tea, resveratrol which is found in red wine, turmeric which is used in curries and lycopene found in tomatoes, as well as some components in cosmetic creams, are known to neutralise this damage within the cells. They can slow down the damage and the rate of ageing and potentially lower the rate of other sun-induced skin lesions.
The method developed offers the first test which enables the comparison of different antioxidants for their potency in a skin cell based system.
Skin cells treated with a panel of antioxidants were exposed to a physiological dose of ultraviolet A radiation that is, the same dose that our skin would normally be exposed to on a warm summer's day. The DNA within the skin cells was then copied using a polymerase chain reaction machine, in order to assess the amount of DNA damage present.
Using this method, Tiron which has the chemical composition 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt monohydrate was revealed to provide 100% protection against mitochondrial DNA damage.
Resveratrol, the antioxidant found in red wine, was found to protect against 22% of both the ultraviolet A radiation and stress-induced damage. NAC, a frequently used laboratory-based anti-oxidant, offered 20% protection against oxidative stress and 8% against UVA and curcumin offered 16% protection against oxidative stress and 8% against UVA.
In comparison Tiron offered 100% protection against UVA radiation and 100% protection against oxidative stress.
The team intends to take the work forward by further understanding the mechanism of how Tiron works,
|Contact: Karen Bidewell|