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Frequent CT scanning for testicular cancer surveillance associated with secondary malignancies
Date:3/30/2011

men are likely to get secondary malignancies than are liable to die from their active disease."

What surprised Chamie and the other researchers is that the risk of secondary cancers after repeated CT scans was more significant in older men than in younger men. Chamie suspects that is because younger bodies can more easily repair DNA damage caused by radiation exposure.

Chamie said that 70 percent of patients with early-stage disease are cured after testicle-removal surgery, so for them, additional surgery to remove lymph nodes or chemotherapy would be unnecessary overtreatment. However, of those who opt only for active surveillance, 30 percent will go on to develop additional cancers that were not detected on CT scans.

"So, do we sacrifice the 70 percent? Or do we put 30 percent at risk of having progression and downstream effects of too many CT scans and chemotherapy?" Chamie said. "We need to do something other than active surveillance."

Chamie said he hopes the findings lead to better ways to stratify patients in terms of who should be eligible for different treatment approaches, limiting active surveillance only to those men whose cancers are least likely to progress. In addition, he suggested use of alternative imaging techniques, including ultrasound and MRI, or less frequent use of CT imaging.


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Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

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