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Freiburg scientist is awarded the Paul Ehrlich and Ludwig Darmstaedter Prize
Date:3/14/2014

mponent of the immune system. When activated, these blood cells produce antibodies to fight off infection. Reth investigates the structure and organisation of the B cell antigen receptors. These molecules on the surface of B cells recognise foreign substances, so-called antigens, and trigger the activation of the immune system. Reth was able to describe the basic structure of the antigen receptor of B cells for the first time in 1989. Together with his research group, he developed a new model for the activation of this receptor and recently provided further experimental evidence for this model.

Furthermore Reth has shown that receptors on the plasma membrane have a more complex structure than previously assumed. They are not freely diffusing on the cell surface but are organized in 50 to 150 nanometre sized membrane patches also called protein islands.

Reth is the third researcher from the Max Planck Institute of Immunobiology and Epigenetics to be awarded the Paul Ehrlich and Ludwig Darmstaedter Prize. Otto Lderitz (who won the prize in 1965) and Otto Westphal (who won in 1968), both directors at the Max Planck Institute in Freiburg, also received the award for their work on the structure and effect of bacterial toxins, or so-called lipopolysaccharides.


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Contact: Dr. Michael Reth
michael.reth@bioss.uni-freiburg.de
49-761-510-8420
Max-Planck-Gesellschaft
Source:Eurekalert  

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