Navigation Links
Fractional dose of scarce meningitis vaccine may be effective in outbreak control
Date:12/5/2008

One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa.

In a study initiated by the Norwegian Institute of Public Health, together with Epicentre (the research arm of Doctors Without Borders/Mdecins Sans Frontires), and Mbarara University of Science and Technology in Uganda, immune responses in patients receiving smaller doses of a meningitis vaccine were found to be comparable to a full dose.

In 2004, a randomized clinical trial of 750 healthy volunteers (2-19 years old) took place in Uganda. Their immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses compared to a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to a full dose for three serogroups (A, Y, W135), but not a fourth (C).

In view of the current shortage of meningococcal vaccines for Africa, the use of 1/5 fractional doses should be considered as an alternative in mass vaccination campaigns. The study's findings contributed to a 2007 WHO recommendation that a fractional dosing strategy be utilized in the event of severe vaccine shortages during a meningitis epidemic.


'/>"/>

Contact: Media Contact
julie.johansen@fhi.no
Norwegian Institute of Public Health
Source:Eurekalert

0

GOOD

Page: 1

Related biology news :

1. New discovery on role of vital protein that fights meningitis
2. Possible hepatitis C vaccine
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. New nanoparticle vaccine is more effective but less expensive
5. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
6. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
7. An Alzheimers vaccine?
8. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
9. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
10. HIV isolate from Kenya provides clues for vaccine design
11. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Orlando, FL (May 18, 2013) Research presented ... for managing digestive health through diet and lifestyle. ... often plagued by reduced muscle strength, fatigue and ... even when patients are in remission. A randomized, ... time that vitamin D supplementation corresponded to significant ...
(Date:5/17/2013)... The AGA Research Foundation announced a new grant that ... gut microbiota, one of today,s most exciting areas of ... AGA Research Awards Panel selected Andrew T. Chan, MD, ... Harvard Medical School, Boston, as the 2013 AGA-Elsevier Gut ... $25,000 of funding, commencing in July 2013, to test ...
(Date:5/17/2013)... Jersey, and City University of New York have invented ... effectively clears organisms to be viewed under microscopes. Visikol ... is one of the few high-quality clearing solutions currently ... Enforcement Administration (DEA) due to its use as a ... for viewing organisms under a microscope. Without them, microscope ...
Breaking Biology News(10 mins):Research examines new methods for managing digestive health 2Research examines new methods for managing digestive health 3New gut microbiome research to explore red meat -- colorectal cancer pathway 2New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3
... used a fluorescent marker to predict the individual ... engineered to illuminate stress levels, implying living organisms ... to deal with the rigors of life. , ... genetically identical nematodes were engineered with a green ...
... in the June 20 issue of The Journal of ... led by Colin Tinsley may have discovered how a ... meningitis. , The human body harbors many harmless bacterial ... meningitidis, makes its home in the upper respiratory tract, ...
... significant new advances in determining the structure of all ... takes up where Watson and Crick left off, after ... blueprint for life. , One of the fundamental problems ... molecule from its sequence ?this has been referred to ...
Cached Biology News:Fluorescing lab worms signal longer life spans 2Fluorescing lab worms signal longer life spans 3Major advance made on DNA structure 2Major advance made on DNA structure 3
(Date:5/21/2013)... Emerson Resources Inc. , a premier pharmaceutical ... Company’s Chief Executive Officer and Chairman of the Board, ... service. As part of Emerson Resources’ planned leadership succession ... as Dr. Signorino’s successor. , Dr. Signorino is ... a significant contribution to the field during his extensive ...
(Date:5/21/2013)... , May 21, 2013  Personal Genome Diagnostics ... its proprietary methodologies and expertise in genomic analysis ... targets in collaboration with Blueprint Medicines.  PGDx is ... identifying genomic alterations in tumors, and Blueprint Medicines ... inhibitors for a genetically defined patient population. ...
(Date:5/21/2013)... NANONEX CORPORATION, a pioneer and leading company in ... delivery and installation of a new nanoimprint lithography ... Japanese manufacturing company. , Nanonex’s ... tool that has the ability to process a ... Based on Nanonex inventions and proprietary technologies, including ...
(Date:5/21/2013)... 2013 Possible mold re-infestation in Guilemtte School ... a report from eagletribune.com posted May 14, 2013, the state ... result is positive, My Cleaning Products offered a tip ... , It was said in the Eagle Tribune report (5.14.13) ... campus sparked after a first-grade classroom was closed due to ...
Breaking Biology Technology:Emerson Resources Announces CEO Retirement and Appointment of Successor 2Emerson Resources Announces CEO Retirement and Appointment of Successor 3Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 2Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 3Nanonex Announces the Shipment and Installation of an Innovative Nanoimprint Lithography System for Fully Automated Manufacturing 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 3
... "Most Innovative" award by the Association of ... Chinese Canadian Entrepreneurs, ... a biotechnology company discovering and developing the next wave of,antibody ... Executive Officer, received the "Most Innovative" award at the,Chinese Canadian ...
... chemotherapy would welcome an advance promising to dramatically reduce ... researchers at Washington University School of Medicine in St. ... , The researchers focused a powerful drug directly on ... a drug dose 1,000 times lower than used previously ...
... EntreMed, Inc.,(Nasdaq: ENMD ), a clinical-stage ... and inflammatory diseases, today,announced that on April 4, ... Qualifications Department of the NASDAQ Stock Market, LLC. ... "Minimum Bid,Price Requirement," stated that the Company,s common ...
Cached Biology Technology:ARIUS recognized for entrepreneurial excellence 2Nanosized technology has supersized effect on tumors 2Nanosized technology has supersized effect on tumors 3EntreMed Receives Nasdaq Deficiency Notice 2EntreMed Receives Nasdaq Deficiency Notice 3EntreMed Receives Nasdaq Deficiency Notice 4
...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... pLivSelect is a direct antibiotic-based selection system ... on colony survival, eliminating the need for ... process provides close to 100% accuracy in ... platform for robot colony picking. This cloning ...
Biology Products: