Navigation Links
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
Date:7/28/2009

xactly where DLX5 protein binds to the promoter region of the MYC gene. They found that there were two sites where DLX5 could bind to the MYC promoter, which is a section of DNA where certain proteins known as transcription factors attach in order to recruit the cellular machinery used to transcribe genes into messenger RNA and then proteins. Studies in both cells and a mouse model for cancer showed that they could promote the expression of MYC by transfecting cells with DNA strands containing DLX5.

Too much DLX5, they found, led to too much MYC. When they knocked out expression of DLX5 in lung cancer cells, it resulted in decreased expression of MYC and reduced cell proliferation. By adding an overabundance of MYC, they found they could turn those cells cancerous again.

From this, Testa and Xu were able to gain a broader understanding of how cancers involving AKT2, DLX5 and MYC might develop. A mutation in AKT2 may act as a "first hit" that makes the inversion on mouse chromosome 6, which contains the DLX5 gene, more likely. When the inversion happens, the cell begins producing the DLX5 protein, a multipurpose transcription factor that normally has a very limited role in adult cells. One of the targets of DLX5 is the MYC gene itself, causing the cells to produce many copies of the MYC oncoprotein.

Normally MYC regulates many functions within the cell, including cell division. With an overabundance of MYC, the cell may reproduce out of control, accumulating in each generation the further genetic damage that is the hallmark of cancer cells.


'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
2. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
3. McPherson County Kansas to Purchase Stingers
4. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
5. Canyon County Idaho Sheriffs Office to Purchase Stinger S-200s
6. bioMETRX, Inc. Completes Sequiam Asset Purchase
7. 1-hit event provides new opportunity for colon cancer prevention, say Fox Chase researchers
8. Dogs chase efficiently, but cats skulk counterintuitively
9. G. Unger Vetlesen Foundation funds purchase of state-of-the-art equipment for UMs Rosenstiel School
10. Researchers identify proteins involved in new neurodegenerative syndrome
11. Texas researchers and educators head for Antarctica
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... When are athletes who have suffered concussions ready to ... has found that high school athletes who head back ... experience a significant regression in their abilities to simultaneously ... as seen in changes in their balance and/or altered ... Ten of the 12 had returned to activity in ...
(Date:8/20/2014)... a chili pepper causes a burning spiciness that is ... the chili pepper,s effect are using their findings to ... pain, which can be caused by inflammation or other ... is being tested in clinical trials, in ACS, ... colleagues explain that decades ago, scientists had pegged a ...
(Date:8/20/2014)... rugs and plastic bags could one day be made ... petroleum, scientists are now reporting. The novel process they ... deal with its agricultural and plastic waste problems, appear ... Athanassiou, Ilker S. Bayer and colleagues at the Italian ... constantly growing. In 2012, its production reached 288 million ...
Breaking Biology News(10 mins):Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... TALLAHASSEE, Fla. -- Reductions in the flow of the ... to grouper and other reef fish populations in the ... State University study that may provide new ammunition for ... The Florida State researchers found that in years with ...
... The SIB Swiss Institute of Bioinformatics today announced the winners ... Young Bioinformatician Award at the 7th annual [BC]2 Basel Computational ... , The winner of the 2009 SIB Young Bioinformatician ... working for the past four years with the SIB in ...
... Discovered Interferon Response May Offer Early Control of H5N1 Influenza ... protein, interferon type 1, reduced H5N1 influenza virus replication in ... early stages of infection. They report their findings in ... . Highly pathogenic avian influenza H5N1 ...
Cached Biology News:Troubled waters: Low Apalachicola River flow may hurt gulf fisheries 2Troubled waters: Low Apalachicola River flow may hurt gulf fisheries 3The SIB recognizes the next generation of bioinformaticians 2The SIB recognizes the next generation of bioinformaticians 3Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4
(Date:8/21/2014)... LYNBROOK, N.Y. , Aug. 21, 2014 /PRNewswire/ ... a biopharmaceutical company developing first in class collagenase-based ... histolyticum or CCH) in the U.S. and XIAPEX ... statistically significant results from a randomized, double-blind Phase ... of cellulite, or edematous fibrosclerotic panniculopathy. The results ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
(Date:8/21/2014)... 2014 Deep Research Report ... professional and in-depth research report on the ... Seaweed Fertilizer information, including Seaweed Fertilizer definition, ... well as industry overview. This research covers ... as well as global industry analysis covering ...
(Date:8/21/2014)... August 21, 2014 His Majesty Willem-Alexander, ... , The Court of His Majesty Willem-Alexander, King of ... the Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY ... 3. , The King will take part in the ... scheduled for 11 a.m.-12:20 p.m. and tour the plant. ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Some of the first data from a new orbiting infrared ... analogy galaxies in general - is making new stars at ... findings from NASA's Spitzer Space Telescope were announced today (May ... a University of Wisconsin-Madison astronomer and the leader of a ...
... for 10 years in tax credits , ,MADISON ... Wisconsin was discussed at an economic development breakfast panel ... Business Development Center at the MG&E Innovation Center. A ... and private sector, discussed the implications of new tax-credit ...
... Formulatrix Inc. and Bruker AXS have ... incubation and imaging products. , ,Crystal Farm, developed by ... International , is an integrated product for incubation and ... design drugs. The system will now work with Formulatrixs ...
Cached Biology Technology:Milky Way churning out new stars at a furious pace 2Milky Way churning out new stars at a furious pace 3The impact of ACT 255 on the future of high-tech investment in Wisconsin 2Protein-crystal companies join forces for better imaging process 2
... Mouse monoclonal [APS 26] to Presenilin ... an inherited form of the disease carry ... or the amyloid precursor protein (APP). These ... the longer form of amyloid-beta (main component ...
One-step, microplate or cuvet, colorimetric, linear detection range 6 mg/dL to 100mg/dL. Procedure: 15 min....
[5,6,8,9,12,14,15(n)-3H]Prostaglandin D2, 925 kBq, 25 uCi. Methanol:water:acetonitrile (3:2:1) solution.> 3.0 TBq/mmol, > 80 Ci/mmol.3.7 MBq/ml, 100 uCi/ml. Category: Radiochemicals &Radiation Safety...
... with Purpose -- The Varian ... the highest level of flexibility ... an affordable, easy-to-use system. The ... workstation guarantees success with today's ...
Biology Products: