Navigation Links
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
Date:7/28/2009

Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-cancer drugs, they reason. Their findings are published in the July 31 edition of the Journal of Biological Chemistry, available online now.

Previously the researchers found that a chromosomal inversion a genetic misalignment, where part of the chromosome containing the DLX5 gene gets flipped around during cell division cooperates with another known oncogene, AKT2, to drive cancer in mice. In the current paper, the researchers discover that DLX5 binds to and actively promotes the activity of a gene known as MYC, which evidence has demonstrated is a potent factor in numerous cancers, including lymphoma, lung and pancreatic cancer. Their studies were performed in mouse cancer models and in human cell cultures.

"While MYC has a definite role in cancer, MYC also has an important place in the normal functioning of cells, so it may be difficult to target without killing healthy cells," says Joseph Testa, PhD, a Fox Chase professor and co-author of the study. "DLX5, however, is not generally active in healthy adult cells, so it represents a much more 'druggable' target for cancer inhibition."

According to Testa, DLX5 is a member of the homeobox family of genes, which direct the timing of events in the physical development of a growing fetus, such as when to sprout a limb, for example. In adults, such genes are almost entirely inactive.

After their previous studies demonstrated that expression of the protein encoded by the DLX5 gene correlated with that of the MYC gene, Testa and Jinfei Xu, PhD, a research associate in the laboratory, used a luciferase assay developed from the luciferase enzyme fireflies use to make light to see e
'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
2. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
3. McPherson County Kansas to Purchase Stingers
4. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
5. Canyon County Idaho Sheriffs Office to Purchase Stinger S-200s
6. bioMETRX, Inc. Completes Sequiam Asset Purchase
7. 1-hit event provides new opportunity for colon cancer prevention, say Fox Chase researchers
8. Dogs chase efficiently, but cats skulk counterintuitively
9. G. Unger Vetlesen Foundation funds purchase of state-of-the-art equipment for UMs Rosenstiel School
10. Researchers identify proteins involved in new neurodegenerative syndrome
11. Texas researchers and educators head for Antarctica
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
(Date:5/11/2015)... Calif. , May 11, 2015  Synaptics ... of human interface solutions, today announced the appointment ... President and Chief Financial Officer, reporting to ... replaces Synaptics, current Chief Financial Officer, Kathleen ... 2014. Mr. Ali brings extensive ...
(Date:5/10/2015)... May 11, 2015 Fingerprint Cards (FPC) ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... used by smartphone manufacturers in China . ... communicated revenue guidance of + 1 000 MSEK for 2015.   ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... Conservation Society, the ARC Centre of Excellence for ... that the fishing villages of Madagascara country with ... of fishing regulations, an encouraging finding that bodes ... in the island nation. Specifically, Malagasy ...
... This news release is available in German . ... respect: Even after repeated contact with dirt and dust do their ... the Carnegie Mellon University, Pittsburgh, have now developed the first adhesive ... as the toes of a gecko, but also possesses similar self-cleaning ...
... insects. As such, they are relatively well studied, especially ... are explored most thoroughly. First eastern US butterfly species ... Carl Linnaeus himself, over 250 years ago. For ... been cataloguing species diversity of eastern butterflies, and every ...
Cached Biology News:Surveys find that despite economic challenges Malagasy fishers support fishing regulations 2Surveys find that despite economic challenges Malagasy fishers support fishing regulations 3Gecko-inspired adhesion: Self-cleaning and reliable 2Two new butterfly species discovered in eastern USA 2
(Date:6/3/2015)... 2015 From smart street lighting to ... in enabling success in dealing with important Societal Challenges ... helped bring focus to the role and further potential ... annual meeting last week in Brussels. SPIE ... 28 and 29 May at the Hotel Le Plaza. ...
(Date:6/2/2015)... TORONTO , June 2, 2015 /PRNewswire/ - Aptose ... clinical-stage company developing new therapeutics that target the underlying ... and Drug Administration (FDA) has granted the company orphan ... myeloid leukemia (AML). APTO-253, a first-in-class inducer of the ... a Phase Ib clinical trial in patients with AML, ...
(Date:6/2/2015)... Tauriga Sciences, Inc. (OTCQB:  TAUG) ("Tauriga" or ... interests in the natural wellness sector and in ... announced that it has officially extinguished all further ... for a one-time cash payment of $230,000 USD.  ... entered into a Settlement Agreement (the "Settlement Agreement") ...
(Date:6/2/2015)... -- Meet ARGUS, The World,s First Contactless ... People. Analyze emotions and predict actions. Explore a New ... first Responsive-RPG: "The Eye: Genesis".      (Photo: ... , https://www.youtube.com/watch?v=B1ZEtAZ2Yf8 Imagine ... feelings - and those of others. Being able to ...
Breaking Biology Technology:Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 2Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 3Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 2Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 3Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 4Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 2Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 3Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 4ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 3
... who venture into the conference room at Neohapsis, Inc. ... depicting Kelly Hansen as an entrepreneurial superhero. Created by ... the poster is located at Milwaukee's Discovery World Museum. ... Hall of Entrepreneurs because of the tremendous obstacles Hansen has ...
... Jim Doyles effort to keep Wisconsins five military installations off ... not just because those bases bring nearly $850 million per ... fortress of ideas and materials to be used in the ... attention of national security policymakers. , ,Doyle toured state military ...
... S&C Bank-Eau Claire has made a gift ... Schneider Social Science Hall at the University of Wisconsin-Eau ... S&C Bank gift to the UW-Eau Claire Foundation ... Excellence, the foundation's ongoing campaign for the university's people and ...
Cached Biology Technology:Entrepreneurial Profile Kelly Hansen, CEO of Neohapsis, Inc. 2Entrepreneurial Profile Kelly Hansen, CEO of Neohapsis, Inc. 3Wisconsins untapped defense might: why saving military bases is just a start 2Wisconsins untapped defense might: why saving military bases is just a start 3UW-Eau Claire receives $35,000 remodeling gift 2
Rabbit polyclonal to BCA1 ( Abpromise for all tested applications). Antigen: Generated using E.coli expressed mouse BCA1. Entrez GeneID: 10563 SWISS Protein ID: O43927...
SH3 Proteins II Sampler Kit 10g each...
Tumor Suppressor Sampler Kit 10 mu g each...
Human peripheral blood eosinophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Biology Products: