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Fourth IMPAKT Breast Cancer Conference


"Basic science and clinical medicine move at different pace because they follow different paths. Both however aim at improving strategies to manage cancer patients. We need to efficiently translate the good things from basic science and efficiently implement them in the clinic."

Sherene Loi and Fabrice Andr, IMPAKT 2012 Co-Chairs

IMPAKT 2012 will focus on four major areas:

  • Molecular pathology, the roots of personalized medicine beyond a microscope: emerging data confirms how valuable the role of the initial diagnosis based on the pathology report is and how this can impact treatment decisions
  • Prognostic multigene signature consensus: there is a clear need for a consensus opinion on the clinical relevance of the various prognostic signatures used by clinicians to make decisions on how to best treat patients. Top experts in the field will review the available literature and develop guidelines on how genetic signatures should be used
  • Triple negative breast cancer, a complex disease which requires intense discussions: how to improve survival of these patients with new drugs and new strategies especially after the failure of promising strategies like PARP inhibitors?
  • Tumor heterogeneity and metabolism, pathways to understand how to treat individual patients with new available targets in the era of personalized medicine: clinical implications and an open discussion on the molecular characteristics of cells with distinct phenotypes within the same tumor and on how cancer cells are metabolically rewired

Conference abstracts will be published on Wednesday, 25 April 2012 at 12:00 (CEST) and will be accessible at

The IMPAKT 2012 Press Program will feature new study results on the following topics:

  • Breast cancer, not one disease

Contact: Vanessa Pavinato
European Society for Medical Oncology

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