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Four new psoriasis 'hotspots' identified by U-M geneticists
Date:10/18/2010

Once a full catalog of psoriasis genes has been identified, scientists hope to generate a "psoriasis gene profile" that can predict one's risk of developing the disease and pave the way for innovative treatments. Current treatments, including different types of immunosuppressive agents, aren't always effective and can cause serious side effects though a new drug called Stelara (ustekinumab), which targets one of the genes they discovered, has been giving patients months-long relief, Elder says.

U-M Professor of Biostatistics Goncalo R. Abecasis, D. Phil, was instrumental in designing software and statistical methods to analyze more than 6 million genetic variants from more than 4,000 people.

"It was a pretty daunting task," Abecasis says. "We looked in greater detail at genetic variation than is typical so that we can understand the biology behind psoriasis and build better drugs."


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Contact: Ian Demsky
idemsky@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

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