Navigation Links
Four new psoriasis 'hotspots' identified by U-M geneticists
Date:10/18/2010

ANN ARBOR, Mich. Scientists at the University of Michigan Heath System and their collaborators have found four new DNA "hotspots" that may one day help guide new treatments for psoriasis, one of the most common autoimmune diseases in the country.

Using cutting-edge methods to peer into the hidden genetic underpinnings of the disabling and disfiguring disease, the research, published in Nature Genetics, further maps the as-yet unknown territories of psoriasis and psoriatic arthritis.

The findings could lead to new drug targets and tailored treatments for the skin disease, says James T. Elder, M.D., Ph.D., the Kirk D. Wuepper Professor of Molecular Genetic Dermatology and lead investigator on the study, which included researchers from the Department of Dermatology and School of Public Health.

"This is a hot topic in genetics these days," Elder says. "Even when you add up all the genes that have been found around the world so far, they only account for about 40 percent of the genetic liability to psoriasis. The question among geneticists continues to be, 'Where is the dark matter?' "

The new research builds on past work by the U-M team, whose discoveries have helped to unveil the hereditary factors of the disease and provide scientists with a better understanding of psoriasis' relationship to other autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and lupus.

So far, research worldwide has linked 25 genes to psoriasis, which has a strong hereditary component. Including the new discoveries, Elder's team was involved in finding more than half of them.

Two of the four new susceptibility loci or "hotspots" were strongly linked to psoriatic arthritis, a painful and destructive form of arthritis that affects about 1 in 4 psoriasis patients, Elder says.

The roughly 7.5 million Americans with psoriasis also have a higher risk of dying from related cardiovascular problems.


'/>"/>
Contact: Ian Demsky
idemsky@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. U-M researchers receive largest single collection of psoriasis DNA samples
2. Missing genes link to psoriasis
3. Researchers identify 4 genetic hotspots associated with psoriasis
4. Scientists uncover new genetic variations linked to psoriasis
5. NASA satellite data aid United Nations ability to detect global fire hotspots
6. Hawaiian submarine canyons are hotspots of biodiversity and biomass for seafloor animal communities
7. New study ranks hotspots of human impact on coastal areas
8. Black aspergilli species responsible for infecting corn identified
9. Scientists reveal important clues to how bacteria and viruses are identified as enemies
10. Malarias newest pathway into human cells identified
11. Fountain of youth in bile? Longevity molecule identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Four new psoriasis 'hotspots' identified by U-M geneticists
(Date:9/17/2014)... affordable health care to reproductive technologies, the justice ... ability of people to identify key issues, articulate ... and find the most defensible ways forward. But ... these societal conversations?, The Hastings Center and the ... have teamed up to publish a series of ...
(Date:9/17/2014)... UT Arlington engineering professor and his doctoral student have ... can accumulate water collected from fog and dew., The ... world or deserts around the globe., Cheng Luo, professor ... Heng, PhD candidate in the same College of Engineering ... 25 edition of ACS, (American Chemical Society) ...
(Date:9/17/2014)... has developed, very cleverly, some lessons on how to ... said Joseph Shaw, director of the Optical Technology Center ... structures at the nanoscale, we,ll discover them." , Some ... August during a conference called "The Nature of Light: ... of the University of Arizona College of Optical Sciences. ...
Breaking Biology News(10 mins):Why bioethics literacy matters 2Why bioethics literacy matters 3Shorebird's beak inspires UT Arlington research on water collection 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3
... may not be the answer to mitigating climate change by ... to an international team of plant biologists. The researchers found ... fungi (AMF) -- a type of fungus that is often ... then leads to higher decomposition rates of organic materials, said ...
... the methane on Earth comes from the ocean,s oxygen-rich waters, ... this potent greenhouse gas. Now researchers report that they have ... the most abundant microbes on the planet. The findings ... who made the discovery did not set out to explain ...
... part of the marine ecosystem, fostering biodiversity and protecting ... with pollution and harmful fishing practices, are one of ... One of the solutions to the crisis ... Tel Aviv University,s Department of Molecular Microbiology and Biotechnology, ...
Cached Biology News:Plants' fungi allies may not help store climate change's extra carbon 2Study identifies prime source of ocean methane 2Study identifies prime source of ocean methane 3Viruses could be the key to healthy corals 2
(Date:9/18/2014)... MA (PRWEB) September 18, 2014 ... Molecule Sequencing (tSMS™) technology, announced today the closing ... of investment, led by Genomic Diagnostic Technologies, will ... and diagnostic applications. , Founded in March 2013 ... and Bioinformatics Analyst at Helicos BioSciences, SeqLL has ...
(Date:9/18/2014)... Now a team led by an engineer at Michigan ... that will let scientists slash the cost of one ... Syringe pumps are used to dispatch precise amounts of ... a reaction. They can also cost hundreds or even ... of Michigan Tech students published the library of free ...
(Date:9/18/2014)... USC have developed a new microscopy technology that ... animals at higher-than-ever resolution. , Dubbed "Complementation Activated ... resolutions that are an order of magnitude finer ... the behavior of biomolecules at the nanometer scale. ... by Nature Communications , the researchers behind ...
(Date:9/18/2014)... for computing may have just taken an encouraging step ... led by chemist Stephen O,Brien have discovered new complex ... Combining both properties is very exciting scientifically for the ... devices that might ultimately be designed, in logic circuits ... material, however, has proved difficult until now. , Using ...
Breaking Biology Technology:SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Doing science just got cheaper -- and faster 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Oxides discovered by CCNY team could advance memory devices 2
... Inc., (TSX: IXS.V; OTC Bulletin Board: IXSBF),( http://www.ixsbio.com ... of monoclonal antibodies based on its Dynamic Cross ... a large scale,primate study of DXL625 (CD20), the ... study in cynomolgus monkeys of DXL625, an antibody,directed ...
... Odyssey Thera, Inc. announced,that it has received a ... progress a discovery stage drug candidate into,pre-clinical development. ... as part of the ongoing collaboration with Pfizer., ... of the collaboration with,Pfizer," said John K. Westwick, ...
... (OTC,Pink Sheets: AIMM) today reported a net loss of $86,000, ... ended June 30, 2008, compared with,a net loss of $62,000, ... months ended June 30, 2007. For the six months ended ... share basic and diluted, compared,with net loss of $54,000, or ...
Cached Biology Technology:InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625 2AutoImmune Inc. Reports 2008 Second Quarter Financial Results 2AutoImmune Inc. Reports 2008 Second Quarter Financial Results 3
... a simple high performance method for removing ... without significant dilution of protein solution. ... Detergent-OUT Spin column and collect detergent free ... removing detergent from a maximum of 0.2 ...
... Chemicon Detergent-OUT SDS Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... Med columns are suitable for removing ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7 microns ... large (3-5 mm in diameter) in comparison ...
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
Biology Products: