Navigation Links
Four new psoriasis 'hotspots' identified by U-M geneticists
Date:10/18/2010

ANN ARBOR, Mich. Scientists at the University of Michigan Heath System and their collaborators have found four new DNA "hotspots" that may one day help guide new treatments for psoriasis, one of the most common autoimmune diseases in the country.

Using cutting-edge methods to peer into the hidden genetic underpinnings of the disabling and disfiguring disease, the research, published in Nature Genetics, further maps the as-yet unknown territories of psoriasis and psoriatic arthritis.

The findings could lead to new drug targets and tailored treatments for the skin disease, says James T. Elder, M.D., Ph.D., the Kirk D. Wuepper Professor of Molecular Genetic Dermatology and lead investigator on the study, which included researchers from the Department of Dermatology and School of Public Health.

"This is a hot topic in genetics these days," Elder says. "Even when you add up all the genes that have been found around the world so far, they only account for about 40 percent of the genetic liability to psoriasis. The question among geneticists continues to be, 'Where is the dark matter?' "

The new research builds on past work by the U-M team, whose discoveries have helped to unveil the hereditary factors of the disease and provide scientists with a better understanding of psoriasis' relationship to other autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and lupus.

So far, research worldwide has linked 25 genes to psoriasis, which has a strong hereditary component. Including the new discoveries, Elder's team was involved in finding more than half of them.

Two of the four new susceptibility loci or "hotspots" were strongly linked to psoriatic arthritis, a painful and destructive form of arthritis that affects about 1 in 4 psoriasis patients, Elder says.

The roughly 7.5 million Americans with psoriasis also have a higher risk of dying from related cardiovascular problems.

Once a full catalog of psoriasis genes has been identified, scientists hope to generate a "psoriasis gene profile" that can predict one's risk of developing the disease and pave the way for innovative treatments. Current treatments, including different types of immunosuppressive agents, aren't always effective and can cause serious side effects though a new drug called Stelara (ustekinumab), which targets one of the genes they discovered, has been giving patients months-long relief, Elder says.

U-M Professor of Biostatistics Goncalo R. Abecasis, D. Phil, was instrumental in designing software and statistical methods to analyze more than 6 million genetic variants from more than 4,000 people.

"It was a pretty daunting task," Abecasis says. "We looked in greater detail at genetic variation than is typical so that we can understand the biology behind psoriasis and build better drugs."


'/>"/>

Contact: Ian Demsky
idemsky@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related biology news :

1. U-M researchers receive largest single collection of psoriasis DNA samples
2. Missing genes link to psoriasis
3. Researchers identify 4 genetic hotspots associated with psoriasis
4. Scientists uncover new genetic variations linked to psoriasis
5. NASA satellite data aid United Nations ability to detect global fire hotspots
6. Hawaiian submarine canyons are hotspots of biodiversity and biomass for seafloor animal communities
7. New study ranks hotspots of human impact on coastal areas
8. Black aspergilli species responsible for infecting corn identified
9. Scientists reveal important clues to how bacteria and viruses are identified as enemies
10. Malarias newest pathway into human cells identified
11. Fountain of youth in bile? Longevity molecule identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Four new psoriasis 'hotspots' identified by U-M geneticists
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/9/2016)... Elevay is currently known as ... for high net worth professionals seeking travel for work ... world, there is still no substitute for a face-to-face ... your deal with a firm handshake. This is why ... of citizenship via investment programs like those offered by ...
(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 On ... session at 4,833.32, down 0.22%; the Dow Jones Industrial Average ... 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez ... Inc. (NASDAQ: BIND ). Learn more about these ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
(Date:6/22/2016)... , June 22, 2016 Cell Applications, ... allow them to produce up to one billion ... lot within one week. These high-quality, consistent stem ... preparing cells and spend more time doing meaningful, ... a proprietary, high-volume manufacturing process that produces affordable, ...
Breaking Biology Technology: