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'Fountain of youth' technique rejuvenates aging stem cells
Date:11/27/2012

porous scaffolding that the cells are able to be stimulated by these factors.

Dr. Li and his team then tracked the molecular changes in the tissue patch cells. "We saw certain aging factors turned off," states Li, citing the levels of two molecules in particular, p16 and RGN, which effectively turned back the clock in the cells, returning them to robust and healthy states.

"It's very exciting research," says Radisic, who was named one of the top innovators under 35 by MIT in 2008 and winner of the 2012 Young Engineers Canada award.

Li and Radisic hope to continue their goal to create the most effective environment in which cells from older patients can be given new life. "We can create much better tissues which can then be used to repair defects such as aneurysms," Li says, as well as repairing damage caused by heart attacks.

The study was recently released in the Journal of the American College of Cardiology, the top journal in the field of cardiovascular medicine.


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Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert  

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