Navigation Links
'Fountain of youth' technique rejuvenates aging stem cells
Date:11/27/2012

Toronto, ON (27 November, 2012) -- A new method of growing cardiac tissue is teaching old stem cells new tricks. The discovery, which transforms aged stem cells into cells that function like much younger ones, may one day enable scientists to grow cardiac patches for damaged or diseased hearts from a patient's own stem cellsno matter what age the patientwhile avoiding the threat of rejection.

Stem cell therapies involving donated bone marrow stem cells run the risk of patient rejection in a portion of the population, argues Milica Radisic, Canada Research Chair in Functional Cardiovascular Tissue Engineering at the Institute of Biomaterials and Biomedical Engineering (IBBME) and Associate Professor in the Department of Chemical Engineering and Applied Chemistry at the University of Toronto.

One method of avoiding the risk of rejection has been to use cells derived from a patient's own body. But until now, clinical trials of this kind of therapy using elderly patients' own cells have not been a viable option, since aged cells tend not to function as well as cells from young patients.

"If you want to treat these people with their own cells, how do you do this?"

It's a problem that Radisic and her co-researcher, Dr. Ren-Ke Li, think they might have an answer for: by creating the conditions for a 'fountain of youth' reaction within a tissue culture.

Li holds the Canada Research Chair in Cardiac Regeneration and is a Professor in the Division of Cardiovascular Surgery, cross-appointed to IBBME. He is also a Senior Scientist at the Toronto General Research Institute.

Radisic and Li first create a "micro-environment" that allows heart tissue to grow, with stem cells donated from elderly patients at the Toronto General Hospital.

The cell cultures are then infused with a combination of growth factorscommon factors that cause blood vessel growth and cell proliferationpositioned in such a way within the porous scaffolding that the cells are able to be stimulated by these factors.

Dr. Li and his team then tracked the molecular changes in the tissue patch cells. "We saw certain aging factors turned off," states Li, citing the levels of two molecules in particular, p16 and RGN, which effectively turned back the clock in the cells, returning them to robust and healthy states.

"It's very exciting research," says Radisic, who was named one of the top innovators under 35 by MIT in 2008 and winner of the 2012 Young Engineers Canada award.

Li and Radisic hope to continue their goal to create the most effective environment in which cells from older patients can be given new life. "We can create much better tissues which can then be used to repair defects such as aneurysms," Li says, as well as repairing damage caused by heart attacks.

The study was recently released in the Journal of the American College of Cardiology, the top journal in the field of cardiovascular medicine.


'/>"/>

Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert  

Related biology news :

1. Parents say that healthy eating is challenging for youth who play sports
2. New synthetic biology technique boosts microbial production of diesel fuel
3. New genetic bar code technique establishes ability to derive DNA information from RNA
4. Early detection techniques offer hope for improved outcomes in lung cancer patients
5. Scientists develop new technique that could improve heart attack prediction
6. New rearing system may aid sterile insect technique against mosquitoes
7. Its a trap! New laboratory technique captures microRNA targets
8. New screening technique yields elusive compounds to block immune-regulating enzyme
9. New stem cell technique promises abundance of key heart cells
10. Evaluation of microscopy techniques may help scientists to better understand ancient plants
11. New technique allows simulation of noncrystalline materials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fountain of youth' technique rejuvenates aging stem cells
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... 27, 2016 , ... PBI-Gordon Corporation is pleased to announce Dave Loecke has ... 15-year career with PBI-Gordon, Dave has served in a wide variety of roles. His ... development and launch of many of PBI-Gordon’s most successful products. , “Dave has been ...
(Date:5/26/2016)... , May 26, 2016  Agriculture nutrients are ... Des Moines, Iowa is running their nitrate ... Lake Erie and coastal regions nationwide ... to preventing this widespread issue. NECi Superior ... Upper Peninsula, developed a new, easy to use ...
(Date:5/26/2016)... ... 2016 , ... After several promising treatments in Panama using ... of Knowledge in Panama, a 6 year-old Duchenne’s muscular dystrophy patient received his ... following FDA approval of a second application for a single patient, investigational new ...
(Date:5/25/2016)... Thailand (PRWEB) , ... May 25, 2016 , ... ... participation of a Thai delegation at BIO 2016 in San Francisco. Located at ... sector will be available to answer questions and discuss the Thai biotechnology and ...
Breaking Biology Technology: