Navigation Links
Fountain of youth in bile? Longevity molecule identified
Date:9/15/2010

Montreal September 15, 2010 The human quest for longer life may be one step closer, thanks to research from Concordia University. Published in the journal Aging, a new study is the first to identify the role of a bile acid, called lithocholic acid (LCA), in extending the lifespan of normally aging yeast. The findings may have significant implications for human longevity and health, as yeast share some common elements with people.

"Although we found that LCA greatly extends yeast longevity, yeast do not synthesize this or any other bile acid found in mammals," says senior author Vladimir Titorenko, Concordia University Research Chair in Genomics, Cell Biology and Aging and a professor in the Department of Biology. "It may be that yeast have evolved to sense bile acids as mildly toxic molecules and respond by undergoing life-extending changes. It is conceivable that the life-extending potential of LCA may be relevant to humans as well."

Over 19 000 small molecules screened

Titorenko and colleagues screened more than 19 000 small molecules to test their ability to extend yeast-lifespan. Under both normal and stressed conditions, LCA had a major impact.

"Our findings imply that LCA extends longevity by targeting two different mechanisms," says first author Alexander Goldberg, a Concordia doctoral student. "The first takes place regardless of the number of calories and involves the day-to-day or housekeeping proteins. The second system occurs during calorie-restriction and involves stressor proteins."

"Regardless of their triggers both of these mechanisms work to suppress the pro-aging process," he continues.

Bile acids may be beneficial to health

"Although we have an overall idea how LCA works to extend longevity in yeast, we still need to determine if this is the case for other species," says Titorenko. "We do know from previous studies, however, that bile acids are beneficial to health a
'/>"/>

Contact: Sylvain-Jacques Desjardins
s-j.desjardins@concordia.ca
51-484-824-245-068
Concordia University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists find a biological fountain of youth in new world bat caves
2. Fountain of Youth to be found in the anthill?
3. Summer day camps provide fun; environmental education activities for Humboldt County youth
4. To close achievement gap, US must address major health risks for urban minority youth, study finds
5. Researchers develop dietary formula that maintains youthful function into old age
6. U of M study identifies risk factors of disordered eating in overweight youth
7. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
8. Jefferson scientists identify a new protein involved in longevity
9. Tree-dwelling mammals climb to the heights of longevity
10. Longevity tied to genes that preserve tips of chromosomes
11. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One day about eight years ago, Katia Silvera , ... her father were on a field trip in a mountainous ... they had never seen before. , Unable to identify it, ... The orchid turned out to be an unnamed species. So ... . , "Lophiaris" is the genus name, comprising about 40 ...
(Date:4/17/2014)... If a restaurant ... he can expect his premises to be trashed. Warnings like ... is enough to make restaurant owners pay up. Similarly, mafia-like ... in other birds, nests. If the host birds throw the ... destroying the entire nest. Consequently, it is beneficial for hosts ...
(Date:4/17/2014)... fragmentation of forests in the Amazon help create ... to rapid and widespread forest loss during drought ... findings show that forests in the Amazon could ... with forest fires lead to large-scale loss of ... assistant professor of geography, Penn State. , "We ...
Breaking Biology News(10 mins):Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3
... An international team of investigators at Sanford-Burnham Medical Research ... Centre for Molecular Life Sciences and other organizations have ... also plays a significant role in Frank-Ter Haar syndrome ... on February 12 in the American Journal of ...
... CINCINNATI -- Scientists have discovered a molecular pathway that works ... may lead to new therapies for repairing injury in a ... week,s Proceedings of the National Academy of Sciences ... Children,s Hospital Medical Center and the Brigham & Women,s Hospital ...
... reveals that a common underlying mechanism is shared by ... complex defects in brain development and function. Rett syndrome ... Retardation, X-linked syndrome (ATR-X) have each been linked with ... DNA that make up chromosomes and control how genetic ...
Cached Biology News:Researchers identify mechanism for Frank-Ter Haar syndrome 2Scientists discover molecular pathway for organ tissue regeneration and repair 2A common thread links multiple human cognitive disorders 2
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... the Risks of DVT to Mark U.S. House of ... Coalition to Prevent DVT today announced the launch of ... deep-vein thrombosis (DVT) and to encourage dialogue between healthcare ... A customized recreational vehicle will visit hospitals and ...
... Christine Lawless, MD, has accepted the position as Medical ... medical education (CME), beginning March 2, 2009. Recognized as ... cardiology, Dr. Lawless recently completed her clinical tenure at ... she was Associate Professor of Internal Medicine and Co-Director ...
... March 10 WaferGen Biosystems, Inc. (OTC Bulletin ... analysis systems, today announced that Kumar Kastury, Ph.D., ... will present data on the company,s SmartChip(TM) Real-Time ... Anniversary Quantitative PCR Conference. The conference will ...
Cached Biology Technology:The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 2The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 3The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 4The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 5Former President of Sports Cardiology Consultants, LLC Christine Lawless, MD, MBA, ABCL, FACC, FACSM, Named Medical Director of CME Enterprise 2WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 2WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 3WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 4
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
...
... gradient system uses two Adept CE 4100 ... CE 4200 dual wavelength detector for added flexibility. ... by PowerStream data processing software and interface unit, ... The supplied analytical pumps may be substituted ...
... Highly nutritious peptone, used ... production of bacterial toxins, ... of bacteria with high ... Haemophilus, Neisseria, Pasteurella, Salmonella ...
Biology Products: