Navigation Links
Forsyth scientists trigger cancer-like response from embryonic stem cells
Date:10/13/2008

Boston--Scientists from The Forsyth Institute, working with collaborators at Tufts and Tuebingen Universities, have discovered a new control over embryonic stem cells' behavior. The researchers disrupted a natural bioelectrical mechanism within frog embryonic stem cells and trigged a cancer-like response, including increased cell growth, change in cell shape, and invasion of the major body organs. This research shows that electrical signals are a powerful control mechanism that can be used to modulate cell behavior.

The team of Forsyth Institute scientists, led by Michael Levin, Ph.D., Director of the Forsyth Center for Regenerative and Developmental Biology, have identified a new function for a potassium (KCNQ1) channel, mutations of which are known to be involved in human genetic diseases such as Romano-Ward and Jervell-Lange-Nielsen syndromes. The team interrupted the flow of potassium through KCNQ1 in parts of the Xenopus frog embryo. This resulted in a striking alteration of the behavior of one type of embryonic stem cell: the pigment cell lineage of the neural crest. When mutated, these pigment cells over-proliferate, spread out, and become highly invasive of blood vessels, liver, heart, and neural tube, leading to a deeply hyper-pigmented tadpole.

The body's natural biophysical signals, driven by ion transporter proteins and resulting in endogenous voltage gradients and electric fields, have been implicated in embryonic development and regeneration. The data in this study, which will be published in the Proceedings of the National Academy of Sciences on October 13, 2008, have not only elucidated a novel role for the KCNQ1 channel in regulating key cell behaviors, but for the first time have also revealed the molecular identity of a biophysical switch by means of which neoplastic-like properties can be conferred upon a specific embryonic stem cell sub-population. These data reveal that key properties of embryonic stem cells can be
'/>"/>

Contact: Jennifer Kelly
jkelly@forsyth.org
617-892-8602
Forsyth Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists trace molecular origin of proportional development
2. Sensitive nanowire disease detectors made by Yale scientists
3. Scent on demand: Hebrew University scientists enhance the scent of flowers
4. MSU scientists find new gene that helps plants beat the heat
5. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
6. Brookhaven scientists take off for southeastern Pacific climate study
7. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
8. Scientists identify a molecule that coordinates the movement of cells
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Earth scientists keep an eye on Texas
11. MU scientists see how HIV matures into an infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... In 2015, American consumers will finally be able to ... Although touted as zero-emissions vehicles, most of the cars ... fossil fuel that contributes to global warming. , Now ... device that uses an ordinary AAA battery to produce ... electric current through two electrodes that split liquid water ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... skin fungus linked to dandruff, eczema and other itchy, ... even further global reachesincluding Hawaiian coral reefs and the ... , A review in the scientific journal PLOS ... the fungi of the genus Malassezia in ... datasets from around the world. , University of Hawai,i ...
Breaking Biology News(10 mins):Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... entities conducting research in synthetic biology worldwide grew significantly ... of an interactive map produced by the Synthetic Biology ... The map is available online at http://www.synbioproject.org/map . ... the design and construction of new biological parts and ...
... Centers for Disease Control, about one in six Americans gets ... of raw oysters in the U.S. are estimated to cost ... of health risk from eating raw oysters, Texas A&M University ... scientist Dr. Suresh Pillai and a team of researchers from ...
... 2013 Signal Hill, CA Bowman Design Group, an ... exhibits, and event marketing, is the first and only ... certification from FAMAB, the German exhibition and events industry ... established that the company met or exceeded goals set ...
Cached Biology News:Synthetic biology research community grows significantly 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 3Bowman Design Group is first US company awarded German FAMAB 'Sustainable Company' certification 2
(Date:8/22/2014)... how facets form and develop on platinum nanocubes ... nanocrystal design and reveal that a nearly 150 ... at the nanoscale. , Researchers with the U.S. ... (Berkeley Lab) used highly sophisticated transmission electron microscopes ... the physical mechanisms that control the evolution ...
(Date:8/22/2014)... DUBLIN , Aug. 22, 2014 ... the "Global and China Gel Permeation Chromatography (GPC) ... The Global and China Gel Permeation Chromatography ... on the current state of the global gel permeation ... The report provides a basic overview of the ...
(Date:8/22/2014)... Canada (PRWEB) August 22, 2014 ... in model organisms can be accelerated by exome ... and manufacturing technologies, the custom SeqCap EZ Developer ... research. , Mr. Watson will additionally present how ... with commercially available human and mouse exome kits. ...
(Date:8/21/2014)... for Molecular Medicine Finland (FIMM), University of Helsinki, ... "man and machine" decision support system for diagnosing ... in PLOS One scientific journal today, ... vision algorithms similar to those used in facial ... diagnostically most relevant areas. Tablet computers can be ...
Breaking Biology Technology:Shaping the future of nanocrystals 2Shaping the future of nanocrystals 3Shaping the future of nanocrystals 4Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2A novel 'man and machine' decision support system makes malaria diagnostics more effective 2
... GeoPharma, Inc. (Nasdaq:,GORX) (the "Company") announced today in an ... audience as possible it has placed both of the ... at, http://www.GeoPharmainc.com under the "Analyst Coverage" tab in ... publicly several times in,the next few months., In ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced that ... is scheduled to present,a company overview at the BIO ... February 11 at 11:45 a.m. EST., To access ... on to http://www.rigel.com . Please connect to Rigel,s ...
... Feb. 6 Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; MTAX) management will ... at 1:15 PM in the West Foyer,of the Waldorf-Astoria Hotel., The presentation ... The webcast can be accessed at, http://www.cticseattle.com ., , ... BIO CEO & Investor Conference ...
Cached Biology Technology:Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3
Mouse polyclonal antibody raised against a partial recombinant RDH5. NCBI Entrez Gene ID = 5959...
Mouse monoclonal antibody raised against a partial recombinant ALPK3. NCBI Entrez Gene ID = ALPK3...
... Lines ,High Quality, Functionally-Validated, Ion Channel Cell ... for having a critical role in nerve ... key function in pain, CNS and the ... been investigated in therapeutic areas, such as ...
Mouse monoclonal antibody raised against a full length recombinant SLC25A11. NCBI Entrez Gene ID = SLC25A11...
Biology Products: