Navigation Links
Forsyth scientists trigger cancer-like response from embryonic stem cells
Date:10/13/2008

Boston--Scientists from The Forsyth Institute, working with collaborators at Tufts and Tuebingen Universities, have discovered a new control over embryonic stem cells' behavior. The researchers disrupted a natural bioelectrical mechanism within frog embryonic stem cells and trigged a cancer-like response, including increased cell growth, change in cell shape, and invasion of the major body organs. This research shows that electrical signals are a powerful control mechanism that can be used to modulate cell behavior.

The team of Forsyth Institute scientists, led by Michael Levin, Ph.D., Director of the Forsyth Center for Regenerative and Developmental Biology, have identified a new function for a potassium (KCNQ1) channel, mutations of which are known to be involved in human genetic diseases such as Romano-Ward and Jervell-Lange-Nielsen syndromes. The team interrupted the flow of potassium through KCNQ1 in parts of the Xenopus frog embryo. This resulted in a striking alteration of the behavior of one type of embryonic stem cell: the pigment cell lineage of the neural crest. When mutated, these pigment cells over-proliferate, spread out, and become highly invasive of blood vessels, liver, heart, and neural tube, leading to a deeply hyper-pigmented tadpole.

The body's natural biophysical signals, driven by ion transporter proteins and resulting in endogenous voltage gradients and electric fields, have been implicated in embryonic development and regeneration. The data in this study, which will be published in the Proceedings of the National Academy of Sciences on October 13, 2008, have not only elucidated a novel role for the KCNQ1 channel in regulating key cell behaviors, but for the first time have also revealed the molecular identity of a biophysical switch by means of which neoplastic-like properties can be conferred upon a specific embryonic stem cell sub-population. These data reveal that key properties of embryonic stem cells can be
'/>"/>

Contact: Jennifer Kelly
jkelly@forsyth.org
617-892-8602
Forsyth Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists trace molecular origin of proportional development
2. Sensitive nanowire disease detectors made by Yale scientists
3. Scent on demand: Hebrew University scientists enhance the scent of flowers
4. MSU scientists find new gene that helps plants beat the heat
5. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
6. Brookhaven scientists take off for southeastern Pacific climate study
7. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
8. Scientists identify a molecule that coordinates the movement of cells
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Earth scientists keep an eye on Texas
11. MU scientists see how HIV matures into an infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... 2014 Leading Biometric companies aim to ... revolutionizing online transactions.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Google Inc. (NASDAQ: GOOG ), ... EBAY ) and MasterCard Inc. (NYSE: MA) ... a biometric authentication company focused on the growing mobile commerce ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
(Date:11/4/2014)... SALT LAKE CITY, Nov. 5, 2014 – University of ... uses enzymes to help jet fuel produce electricity without ... can be used to power portable electronics, off-grid power ... appears online today in the American Chemical Society journal ... into electricity through a chemical reaction between a fuel ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Jet-fueled electricity at room temperature 2
... at the U.S. Department of Energy,s Lawrence Berkeley National ... into wispy nanoscale ropes that approach the structural complexity ... development in the push to develop self-assembling nanoscale materials ... but which are rugged enough to withstand harsh conditions ...
... Energy,s Pacific Northwest National Laboratory has been recognized for ... The award-winning partnerships are helping analyze trace amounts of ... and more easily study live cells., The Federal Laboratory ... 2011 for Excellence in Technology Transfer. The consortium is ...
... have proven that you don,t have to travel to exotic ... distinctive species of crayfish in Tennessee and Alabama that is ... genetic relative, once thought to be the only species in ... in Kentucky, can grow almost as big as a lobster. ...
Cached Biology News:A nanoscale rope, and another step toward complex nanomaterials that assemble themselves 2A nanoscale rope, and another step toward complex nanomaterials that assemble themselves 3PNNL recognized for technology transfer 2PNNL recognized for technology transfer 3Researchers discover giant crayfish species right under their noses 2Researchers discover giant crayfish species right under their noses 3Researchers discover giant crayfish species right under their noses 4
(Date:11/26/2014)... On January, 14, 2015, UMBC’s ... D.C. science community to the UMBC campus for a ... the Protein Society, will take place from 9 a.m. ... Through discussion, presentations and workshops, the free symposium ... their role in the industry and the future of ...
(Date:11/26/2014)... PMG Research, Inc. announced today ... a network of sites that provide clinical research services to ... patient lives through its partnerships with large physician practices and ... site locations in the Southeastern United States and spans over ... board will be held by: Dr. Robert Holmes, ...
(Date:11/26/2014)... NC (PRWEB) November 25, 2014 ... Intensity Focused Ultrasound (HIFU) devices, recently participated in ... Small Renal Mass 360° .” Key opinion leaders ... therapeutic advances related to small renal masses while ... about different ablative technologies in hands-on labs. Attendees ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Continuing its ... products, earned three prestigious MarCom Awards for outstanding creative ... received a Platinum MarCom Award, the organization’s top honor, ... in St. Louis held in April of this year. ... than 14,000 attendees. Additionally, Nerium was awarded a Gold ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... using Adult Stem Cells drives,awareness among viewers; NeoStem ... NEW YORK, Oct. 8 NeoStem, Inc. (Amex: ... processing and long-term,storage of adult stem cells for ... adult stem cell public awareness program, a key ...
... VRUS ) management will present at the ... 13-14, 2008 at the Waldorf Astoria,in New York ... an overview of the company on Monday, October ... Pharmasset is a clinical-stage pharmaceutical company committed ...
... LS9, Inc., the,Renewable Petroleum Company(TM), today announces it ... Haywood brings over 30 years of,experience in the ... of,planning, engineering, execution and start-up of major projects ... be pivotal to LS9 as the company delivers,significant ...
Cached Biology Technology:Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 2Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 3Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 4LS9, Inc. Appoints Bill Haywood Chief Executive Officer 2