Navigation Links
Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
Date:12/15/2008

Dr. Antonio Campos-Neto, head of the department of Cytokine Biology at The Forsyth Institute, has received a major grant from the internationally renowned Foundation for Innovative New Diagnostics (FIND) to continue his work to develop a test to diagnose active Tuberculosis (TB), the world's second deadliest infectious disease. Dr. Campos-Neto aims to create a rapid, sensitive, non-invasive and accurate TB diagnostic test, modeled after a pregnancy test, which would identify the TB bacterium's molecules present in a patient's urine.

TB is a leading cause of death worldwide, with 1.7 million deaths and 9 million new active cases annually. TB cases are already at epidemic levels in Africa and are on the rise in developing countries throughout the world, particularly among HIV/AIDS patients. This resurgence combined with the ease of transmission through coughing, sneezing and other common activities, and the emergence of drug resistant TB strains is leading to a growing fear of a global spread of the disease.

Among the main barriers to preventing the spread of TB are the shortcomings of existing diagnostic tests, including: inaccurate diagnoses, limited test sensitivity, invasive sample collection, time-consuming testing and most importantly, failure to distinguish between active and latent cases.

"We are in the preliminary stages of establishing a methodology that allows us to detect minute traces of the TB antigens that are excreted in the urine by a TB-infected patient. What is so exciting about this project is that if we are successful it will contribute tremendously to the control of a disease that kills close to two million people every year," says Dr. Campos-Neto.

The research has already detected molecules produced by TB in the urine of infected mice and humans. Establishing a test that can be used in a clinical setting offers several potential benefits:

  • confirming the diagnosis of active TB, not latent or dormant infection
  • the test does not require expensive equipment and can be performed anywhere in the world, including the most remote locations
  • the test result is easy to read and obtained in less than five minutes, enabling the immediate initiation of treatment
  • urine is a far easier sample to collect and, unlike current sample collection, is completely non-invasive
  • the presence of TB antigens in urine may be detectable earlier than through other samples, leading to earlier treatment and increased survival rates

Philip Stashenko, President and CEO of The Forsyth Institute, says, "Dr. Campos-Neto's research offers a tremendous opportunity to address a critical worldwide public health problem, and extends the Institute's mission to study systemic disease. This would be an important breakthrough in the diagnosis and treatment of TB."

Recent studies show that an improved TB diagnostic test could save as many as 625,000 lives every year. Without a new, more efficient and more reliable diagnostic test, TB will continue to spread at alarming rates.


'/>"/>

Contact: Matt Ellis
matt@ellisstrategies.com
978-887-6561
Forsyth Institute
Source:Eurekalert

Related biology news :

1. Forsyth scientists trigger cancer-like response from embryonic stem cells
2. UK scientists working to help cut ID theft
3. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
4. Comet probes reveal evidence of origin of life, scientists claim
5. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
6. Male elephants get photo IDs from scientists
7. Scientists retrace evolution with first atomic structure of an ancient protein
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
10. Clemson scientists shed light on molecules in living cells
11. Scientists tackle mystery mountain illness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... , June 15, 2016 ... report titled "Gesture Recognition Market by Application Market - Global Industry ... - 2024". According to the report, the  global gesture ... in 2015 and is estimated to grow at ... billion by 2024.  Increasing application of ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
Breaking Biology Technology: