Navigation Links
Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
Date:12/15/2008

Dr. Antonio Campos-Neto, head of the department of Cytokine Biology at The Forsyth Institute, has received a major grant from the internationally renowned Foundation for Innovative New Diagnostics (FIND) to continue his work to develop a test to diagnose active Tuberculosis (TB), the world's second deadliest infectious disease. Dr. Campos-Neto aims to create a rapid, sensitive, non-invasive and accurate TB diagnostic test, modeled after a pregnancy test, which would identify the TB bacterium's molecules present in a patient's urine.

TB is a leading cause of death worldwide, with 1.7 million deaths and 9 million new active cases annually. TB cases are already at epidemic levels in Africa and are on the rise in developing countries throughout the world, particularly among HIV/AIDS patients. This resurgence combined with the ease of transmission through coughing, sneezing and other common activities, and the emergence of drug resistant TB strains is leading to a growing fear of a global spread of the disease.

Among the main barriers to preventing the spread of TB are the shortcomings of existing diagnostic tests, including: inaccurate diagnoses, limited test sensitivity, invasive sample collection, time-consuming testing and most importantly, failure to distinguish between active and latent cases.

"We are in the preliminary stages of establishing a methodology that allows us to detect minute traces of the TB antigens that are excreted in the urine by a TB-infected patient. What is so exciting about this project is that if we are successful it will contribute tremendously to the control of a disease that kills close to two million people every year," says Dr. Campos-Neto.

The research has already detected molecules produced by TB in the urine of infected mice and humans. Establishing a test that can be used in a clinical setting offers several potential benefits:

  • confirming the diagnosis of active TB, not latent or dormant infection
  • the test does not require expensive equipment and can be performed anywhere in the world, including the most remote locations
  • the test result is easy to read and obtained in less than five minutes, enabling the immediate initiation of treatment
  • urine is a far easier sample to collect and, unlike current sample collection, is completely non-invasive
  • the presence of TB antigens in urine may be detectable earlier than through other samples, leading to earlier treatment and increased survival rates

Philip Stashenko, President and CEO of The Forsyth Institute, says, "Dr. Campos-Neto's research offers a tremendous opportunity to address a critical worldwide public health problem, and extends the Institute's mission to study systemic disease. This would be an important breakthrough in the diagnosis and treatment of TB."

Recent studies show that an improved TB diagnostic test could save as many as 625,000 lives every year. Without a new, more efficient and more reliable diagnostic test, TB will continue to spread at alarming rates.


'/>"/>

Contact: Matt Ellis
matt@ellisstrategies.com
978-887-6561
Forsyth Institute
Source:Eurekalert

Related biology news :

1. Forsyth scientists trigger cancer-like response from embryonic stem cells
2. UK scientists working to help cut ID theft
3. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
4. Comet probes reveal evidence of origin of life, scientists claim
5. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
6. Male elephants get photo IDs from scientists
7. Scientists retrace evolution with first atomic structure of an ancient protein
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
10. Clemson scientists shed light on molecules in living cells
11. Scientists tackle mystery mountain illness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... , ... June 23, 2017 , ... Biova, LLC., the ... has joined Biova’s Board of Directors. Dr. Henig will bring a wealth of scientific ... has served as the Chief Technical and Scientific Officer of four major global companies ...
(Date:6/23/2017)... ... June 23, 2017 , ... The ... hobbyists, and the University Aviation Association (UAA), the unifying voice for collegiate aviation ... Challenge will encourage teamwork, competition, and success through a STEM-based education platform. , ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... taking over the allergy specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding ... know someone who suffers from hay fever, urticaria, asthma, atopic eczema or a ...
(Date:6/22/2017)... , ... June 22, 2017 , ... The first human ... 20 years until the first data on cross-contamination of human cell lines with HeLa ... an increasing issue in cell culture labs and is associated with dramatic consequences for ...
Breaking Biology Technology: