Navigation Links
Formula-fed preemies at higher risk for dangerous GI condition than babies who get donor milk
Date:4/30/2011

Extremely premature babies fed human donor milk are less likely to develop the dangerous intestinal condition necrotizing enterocolitis (NEC) than babies fed a standard premature infant formula derived from cow's milk, according to research by investigators at the Johns Hopkins Children's Center and elsewhere.

Only one of the 29 infants who received human milk developed NEC and it recovered without surgery, compared with five out of the 24 babies on formula, four of whom required surgery. The findings, the researchers said, justify a move toward a "human milk only" diet in extremely premature babies -- those born weighing less than 1,500 grams, or 3.3 pounds.

"The stark differences in the risk of NEC, its complications and the need for surgery between babies who receive human donor milk and those who get formula signal the need for a change in feeding practices across neonatal intensive care units," said lead investigator Elizabeth Cristofalo, M.D., a neonatologist at the Johns Hopkins Children's Center.

Moreover, babies who got human milk tolerated feeding better, allowing them to be taken off supplemental IV nutrition much sooner -- after 27 days on average -- than the group who received cow's milk formula. Those babies spent an average of 36 days on IV nutrition, largely because their intestinal tracts were not adapting to food as well, the researchers say. IV nutrition, used temporarily in all premature babies to supplement feeding, carries risks, the most serious of which is liver damage.

"Although we didn't look specifically at liver function, we know from experience and from previous research that prolonged IV nutrition can harm a premature baby's liver," Cristofalo said. "Using human milk cuts that risk by allowing us to wean babies off IV nutrition sooner."

The health advantages of mother's milk have been well-established, but some concerns about donor milk have lingered, including how it compares to mother's milk and whether it is, indeed, superior to cow milk formula. The new findings should resolve any residual doubts about the risks and clarify the benefits of human donor milk, the investigators said.

The multi-center study is the first trial of its kind to compare the risk for NEC and NEC surgery between premature infants fed human donor milk and those fed preterm baby formula. An earlier study by the same team showed that babies who get their own mother's milk fortified with the standard cow milk protein are more prone to NEC than babies given a combination of their mothers' milk fortified with human donor milk.

Necrotizing enterocolitis is marked by tissue damage to the baby's bowel. Because up to 40 percent of babies who develop NEC die, the condition is considered an emergency. Some cases of NEC can be treated with antibiotics and by temporarily withholding of food, but some babies require surgery to remove the dead portions of the intestines. The remaining intestine, however, can develop scarring that leads to poor absorption of nutrients, growth problems and the need for more surgery down the road.


'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-926-6780
Johns Hopkins Medical Institutions
Source:Eurekalert

Related biology news :

1. Researchers identify biomarkers of poor outcomes in preemies
2. Higher prevalence of psychiatric symptoms found in children with epilepsy
3. American birds of prey at higher risk of poisoning from pest control chemicals
4. Arctic fisheries catches 75 times higher than previous reports: UBC research
5. Poor response to anti-anemia drug predicts higher risk of heart disease or death
6. Women war veterans face higher risk of mental health problems during pregnancy
7. Decline of West Coast fog brought higher coastal temperatures last 60 years
8. Higher co-payments increase chance of early discontinuation, inadequate use of breast cancer therapy
9. Drinking 100 percent fruit juice is linked to higher intake of essential nutrients
10. Life expectancy higher in Israel than in US, according to Ben-Gurion U. researcher
11. Elasticity found to stretch stem cell growth to higher levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
Breaking Biology Technology: