Navigation Links
Form of Crohn's disease traced to disabled gut cells
Date:10/5/2008

St. Louis, Oct. 5, 2008 Scientists report online this week in Nature that they have linked the health of specialized gut immune cells to a gene associated with Crohn's disease, an often debilitating and increasingly prevalent inflammatory bowel disorder.

The link to immune cells intrigued researchers at Washington University School of Medicine in St. Louis because they and others believe Crohn's disease is caused by misdirected immune responses in the intestine that damage gut tissue. In addition, cells in the mouse model scientists used for the study had altered genetic activity that could lead to increased production of certain hormones. Those same hormones are elevated in some Crohn's patients.

"We now have a significant new piece of the puzzle that is Crohn's disease, but not the solution just yet," says senior author Herbert W. "Skip" Virgin, M.D., Ph.D., the Edward Mallinckrodt Professor and head of the Department of Pathology and Immunology. "As many as 30 different areas in human DNA have potential links to Crohn's disease, and to develop new treatments it's going to be essential to find out how each of them, as well as environmental factors, contribute to the disorder."

Crohn's disease is one of the most common inherited bowel disorders. In 2002, epidemiologists estimated that it affected 400,000 to 600,000 patients in North America. Symptoms include diarrhea, abdominal pain, vomiting and weight loss. The condition can lead to partial or full intestinal blockages, which can require surgical treatment.

Research previously revealed that some Crohn's disease patients have a mutation in a gene known as Atg16L1. The mutation increases risk but doesn't automatically lead to Crohn's disease. To learn more, Ken Cadwell, Ph.D., a postdoctoral student in Virgin's lab, created and studied two lines of mice with a genetic alteration that reduced their ability to make the Atg16L1 protein.

Cadwell and his colleag
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. Gender, coupled with diabetes, affects vascular disease development
3. Study links cat disease to flame retardants in furniture and to pet food
4. Humans fostering forest-destroying disease
5. Emerging (disease) markets
6. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
7. Clemson chemists discover new way antioxidants fight debilitating diseases
8. Finding that 1-in-a-billion that could lead to disease
9. Study shows link between alcohol consumption and hiv disease progression
10. Natural chemical found in broccoli helps combat skin blistering disease
11. 60 second test could help early diagnosis of common brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... geologist Juliane Mller the Fram Strait is a key region ... this passage between Greenland and Svalbard warm Atlantic water flows ... west side cold Arctic water masses and sea ice push ... A considerable portion of the Atlantic water cools here on ... The circulation of the water caused in this manner drives ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... involves the pancreas digesting itself resulting in severe abdominal ... UK around 20,000 patients are diagnosed with the disease ... and treatment is restricted to intravenous fluid and nutritional ... of Life Sciences, who led the research, said "The ... gall stones and excessive alcohol intake combined with a ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2
... you get a picky young eater who refuses everything to ... try nutritious foods when all they want is something sweet ... mealtime struggles? In her new book, ... to Raise Healthy Eaters" (Healthy Learning, May 2012), registered dietitian ...
... (May 29, 2012) Physicians and researchers at John Theurer ... cancer centers, will present the latest findings in blood-cancer research ... meeting in Chicago on June 1-5. Their involvement in these ... to bolster its research program. "We are ...
... Organic Electronics research group at Linkping University previously developed ... ions, as well as biomolecules. Tybrandt has now succeeded ... a similar way to traditional silicon-based electronics. ... carrier consists of chemical substances with various functions. This ...
Cached Biology News:'Eat your vegetables!' New book redefines how to raise healthy eaters 2John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting 2
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... NJ (PRWEB) August 20, 2014 WriteResult®, ... announced today that it has expanded its myPROpad™ ePRO ... the EQ-5D-5L, one of the most widely used ... measuring general health status. The EQ-5D is used during ... generate a measure that can be used to demonstrate ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3PAREXEL International To Present At Baird Healthcare Conference 2EQ-5D™ Assessment Now Available for iPad 2
... Thomson Reuters, the,world,s leading source of intelligent ... the National Cancer Institute (NCI) has,joined the ... comprehensive resource for biomarker intelligence to provide,pharmaceutical, ... for assessing and tracking a potential biomarker ...
... ... Initiatives, BEDFORD, Mass., Sept. 3 ... technology with its OmniPod(R),Insulin Management System, today announced the appointment of ... this,role, Mr. Arthur will lead the company,s business development strategy,including pursuing ...
... a Magellan,Biosciences company and leader in novel HPLC ... QA/QC, life science, and,analytical-chemistry customers worldwide, announced that ... American Technology Innovation Award in the,field of integrated ... to ESA,s Vice President of HPLC Products and ...
Cached Biology Technology:The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 2The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 3Insulet Appoints Bill Arthur as Vice President of Business Development 2Insulet Appoints Bill Arthur as Vice President of Business Development 3Insulet Appoints Bill Arthur as Vice President of Business Development 4ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 2ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 3
... The "egg crate" style strip holder is ... bottom strips. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,456-9) or contact customer service ...
... Streptavidin-AP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... pre-amplifier suitable for a broad range of ... recording physiological signal such as ECG, EMG, ... for use with a wide range of ... a stimulus artefact clamp to avoid saturation ...
Biology Products: