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Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
Date:2/17/2009

p>Hekimi and postdoctoral fellow Jeremy Van Raamsdonk studied mutant Caenorhabditis elegans worms. They progressively disabled five genes responsible for producing a group of proteins called superoxide dismutases (SODs), which detoxify one of the main ROS. Earlier studies seemed to show that decreased SOD production shortened an organism's lifespan, but Hekimi and Van Raamsdonk did not observe this. In fact, they found quite the opposite.

None of their mutant worms showed decreased lifespan compared to wild-type worms, even though oxidative stress was clearly raised. In fact, one variety actually displayed increased lifespan, the researchers said.

"The mutation that increases longevity affects the main SOD found in mitochondria inside the animals' cells," said Hekimi. "This is consistent with earlier findings that mitochondria are crucial to the aging process. It seems that reducing mitochondrial activity by damaging it with ROS will actually make worms live longer."

The researchers hasten to point out that they are not suggesting that oxidative stress is good for you.

"ROS undoubtedly cause damage to the body," Hekimi said. "However, they do not appear to be responsible for aging."


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Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

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