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For osteoporosis patients, exercise pill one step closer to reality
Date:4/7/2010

For osteoporosis patients unable to exercise, help may be on the way. That's because scientists have discovered precisely how mechanical stress, such as exercise, promotes new bone growth. This opens the door to entirely new therapies that can trick bones into thinking they are getting a workout. The research report describing this advance is published online in The FASEB Journal (http://www.fasebj.org).

This research provides insight into the identification of the signaling mechanisms used by primary cilia to regulate the capacity of bone cells to sense fluid flow. This crucial information could lead to the development of new drugs that cause the same benefits to the skeleton as exercise, which would be beneficial to patients with osteoporosis.

"We believe that this study takes the field an important step forward in answering a two hundred-year-old question, 'How does bone sense mechanical loads?'" said Christopher R. Jacobs, Ph.D., co-author of the study from the Department of Mechanical Engineering at Stanford University in Stanford, CA. "Ultimately, we hope that the mechanisms identified in this study can be exploited to develop novel treatments for bone loss and perhaps a large number of other diseases involving the remarkably versatile primary cilia."

The research by Jacobs and colleagues builds on existing knowledge about the role of primary cilia (hair-like organelles that line the surfaces of some cells) on fluid flow in bone cells. When bone carries weight during physical exercise, bone cells are subjected to fluid flow, which is detected by primary cilia in bone cells. To make their discovery, the scientists studied an enzyme found in bone cells called adenylyl cyclase 6 (AC6), which is compartmentalized within the primary cilia. This enzyme inactivates very quickly in response to fluid flow, which initiates a signaling cascade that ultimately leads to increased expressio
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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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