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For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
Date:9/24/2008

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Study Summary

The aim of the study was to assess changes in fatty acid (FA) metabolism in response to acute overeating and exercise. Five obese women performed three separate two-day trials in which they consumed (1) a weight-maintaining diet [Control]; (2) a hypercaloric diet (700 calories above normal); and (3) the same hypercaloric diet, but exercised to the point where they expended the 700 excess calories.

The morning after each trial, researchers measured whole-body FA oxidation [FAO] and calculated non-oxidative FA disposal as the difference between FA uptake and FAO.

A muscle biopsy was performed to measure the presences of triglycerides that are involved in fat storage.

The morning after the trials, the researchers observed that overeating suppressed fatty acid oxidation below the control levels, while exercising increased oxidation. Non-oxidative FA disposal was the same in each trial and a direct correlation between FA uptake and muscle GPAT activity were found.

Conclusions

According to Andrea Cornford, a member of the research team, "Exercise decreases everyone's insulin resistance and therefore reduces the chances of developing diseases such as type 2 diabetes. This study shows that even a single bout of exercise helps obese individuals increase their body's fat-burning rate and improve their metabolic health."


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Contact: Donna Krupa
DKrupa@the-aps.org
703-967-2751
American Physiological Society
Source:Eurekalert

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