Navigation Links
Footrot vaccine closer than ever
Date:7/1/2008

Monash University scientists have started clinical trials to find a successful vaccine against footrot in sheep.

The trials have been made possible with funding of $663,000 from Australian Wool Innovation (AWI)

The trials over three years are taking place at Monash University's Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics and the University of Sydney.

Chief investigator Professor Julian Rood said it was an exciting development for his team of researchers.

"The trials are the culmination of 8 years of collaborative work on the pathogenic bacterium which causes footrot, Dichelobacter nodosus. We have determined the bacterium's complete DNA sequence, which was then analysed to identify proteins that are potentially exposed on the surface of the causative bacterium and therefore more likely to elicit an immune response," Professor Rood said.

"The approach, called reverse vaccinology, identified 90 proteins in the footrot bacterium that are potential antigens for a new cross-protective vaccine. This funding will allow us to pinpoint those proteins that will target the disease in a vaccine application," Professor Rood said.

"Our Centre's approach has made significant inroads in the development of a novel vaccine for footrot. The trialling process involves treating sheep with purified surface expressed proteins to assess whether they produce an immune response. The AWI funding means the development of a marketable vaccine is likely to happen a lot sooner. Ideally, this could be within a decade."

Australian Wool Innovation's Program Manager of Animal Health, Productivity and Welfare, Dr Johann Schrder said footrot has long been the bane of Australian woolgrowers and prime lamb producers.

"While many improvements have been made over the years in its control, and we have a very good understanding of measures to limit its impact on production, this avenue of research holds great promise," Dr Schrder said.


'/>"/>

Contact: Samantha Blair
samantha.blair@adm.monash.edu.au
61-399-034-841
Monash University
Source:Eurekalert

Related biology news :

1. Possible hepatitis C vaccine
2. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
3. New nanoparticle vaccine is more effective but less expensive
4. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
5. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
6. An Alzheimers vaccine?
7. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. HIV isolate from Kenya provides clues for vaccine design
10. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
11. Vaccine for Ebola virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... The Conference Forum has announced ... days and will take place on February 1-3, 2017 at the Roosevelt Hotel in ... (NCI), the program provides a unique 360-degree approach, which addresses the most up-to-date information ...
(Date:12/2/2016)...   SurePure, Inc. (OTCQB: SURP) a global ... has concluded an agreement with Tamarack Biotics under which ... to acquire units of the Company,s patented photopurification technology ... Concurrently with the option, SurePure has ... will seek regulatory approvals in the United ...
(Date:11/30/2016)... November 30, 2016 The global ... players hold a dominant share in the overall market. ... International, Inc., and Merck KGaA, held a lion,s share ... Market Research observes that these companies are expected to ... products that are do not require rabbit pyrogen testing ...
(Date:11/30/2016)... Nov. 30, 2016  Tempus, a technology company ... and Penn,s Abramson Cancer Center have partnered to ... response to immunotherapy treatment based on next generation ... part of a research collaboration, Tempus will provide ... cancer patient data to Penn. Utilizing next-generation sequencing, ...
Breaking Biology Technology: