Navigation Links
Food for thought -- regulating energy supply to the brain during fasting
Date:10/5/2008

LA JOLLA, CAIf the current financial climate has taught us anything, it's that a system where over-borrowing goes unchecked eventually ends in disaster. It turns out this rule applies as much to our bodies as it does to economics. Instead of cash, our body deals in energy borrowed from muscle and given to the brain.

Unlike freewheeling financial markets, the lending process in the body is under strict regulation to ensure that more isn't lent than can be afforded. New research by scientists at the Salk Institute for Biological Studies reveals just how this process is implemented.

"We have all seen the sub-prime mortgage crisis," says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology who led the current study. "If you take out a loan, sooner or later you've got to pay your debt, and the same is true in fasting metabolism."

The Salk researchers' findings, which are published ahead of print in the Oct. 5 edition of the journal Nature, may pave the way for novel therapies for sufferers of metabolic diseases in whom such regulation can spiral out of control.

Most tissues in our bodies respond to fasting by switching from their usual high-octane energy sourceglucoseto burning a low-octane, cheaper alternative-fat. For our brains, however, only the high-performance fuel will do. If no food-derived glucose is available, the body must manufacture its own supply to maintain the brain in the manner to which it is accustomed. It does so by taking energy from muscle in the form of protein and converting it to glucose in the liver, a process known as gluconeogenesis. The sugar is then shipped via the bloodstream to the brain to keep it running smoothly.

Gluconeogenesis needs to be turned on rapidly in response to fasting, but shutting it off again is just as crucial. "You don't want gluconeogenesis to be prolonged," says postdoctoral researcher and co-first author Yi Liu,
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ancient marine invertebrate diversity less explosive than thought
2. Britains last Neanderthals were more sophisticated than we thought
3. Sierra Nevada rose to current height earlier than thought, say Stanford geologists
4. Shell-breaking crabs lived 20 million years earlier than thought
5. Food for thought
6. Food for thought: delivering the promise of food processing
7. Toll of climate change on world food supply could be worse than thought
8. Baiji Dolphin previously thought extinct spotted in the Yangtze River
9. CSHL team traces extensive networks regulating alternative RNA splicing
10. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
11. 2 genes are important key to regulating immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... the University of Pittsburgh have created the best method ... molecule wide, a significant step in science,s increasing attempts ... the single molecule scale and provide smaller, faster, and ... today in the Journal of the American Chemical Society ...
... Institute of Technology has been selected by the New ... in Technology Education Award, in recognition of the Institutes ... technological university. Stevens will be honored by the NJTC ... Science Center in Jersey City, N.J., November 15, 2007. ...
... study not only has important findings for the ... thought about what happens when animal species interbreed. ... student Benjamin Fitzpatrick,(now on the faculty of University ... recently in the Proceedings,of the National Academy of ...
Cached Biology News:Stevens wins Excellence in Technology Education Award 2
(Date:4/24/2015)... 24, 2015 Seoul Semiconductor announced ... various applications in the lighting market. In ... of this technology in emerging markets such as ... wide range of applications such as streetlight and ... lighting. , First launched in 2005 the Acrich ...
(Date:4/23/2015)... (PRWEB) April 23, 2015 The ... intends to conduct a groundbreaking pilot study to ... be reversed in as little as three to ... of metabolic and nutritional medicine—will aggressively target and ... and destroy our aging brain. These include oxidative ...
(Date:4/23/2015)... Six startups from Russia traveled ... as part of the U.S.-Russia Innovation Corridor (USRIC) ... biotechnology startups to participate in the program since ... the University of Maryland (UMD) signed a Memorandum ... universities in the biomedical industry in 2013. , ...
(Date:4/23/2015)... Follow us on LinkedIn ... of genetic tests that determine individual susceptibility to ... Huntington's disease, and Alzheimer's disease. Predictive diagnostics are ... interaction in diseased tissue/cells to understand and determine ... response to treatment, such as in the numerous ...
Breaking Biology Technology:Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3
... - In the wake of shareholder lawsuits alleging ... of Merge Technologies, Inc. has accepted the ... ,Bill Mortimore, who founded the company and served as ... been appointed as the company's interim CEO. Mike Dunham, ...
... Hartford-based api Software, Inc . has entered into agreements ... and health systems, for whom it may become a key ... system so that parts of the bundle play a role ... era of severe nursing shortages. , ,Shift bidding, for ...
... for new ways to increase sales tax revenues. Some ... to develop open lands and renovate old structures. Others ... reduced fees to relocate a business within their municipalities. ... large municipalities in Chicago giving away tax incentives and ...
Cached Biology Technology:Merge president steps down in wake of shareholder suits 2Merge president steps down in wake of shareholder suits 3Medical software may be a retention tool 2Electronic signs for municipalities: Las Vegas or lost revenues? 2Electronic signs for municipalities: Las Vegas or lost revenues? 3Electronic signs for municipalities: Las Vegas or lost revenues? 4
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
...
BD Falcon Center-well 60 mm In Vitro Fertilization (IVF) Dish, nonembryotoxic, noncytotoxic, tissue-culture treated polystyrene. (20/sp, 500/ca) Packaging: 20 / sleeve, 500 / case ...
...
Biology Products: