Navigation Links
Food contaminants worsen metabolic problems in obese mice
Date:6/27/2013

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit (U1060 Laboratoire de recherche en cardiovasculaire, mtabolisme, diabtologie et nutrition Inserm/Inra/Universit Lyon 1) introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

The results show that metabolic changes occur in these mice, but that the effects differ depending on the gender. Females appeared to be more affected. Their obesity-induced glucose intolerance worsened and their estrogen pathway was altered.

These works have been published in the review Faseb Journal.

Obesity is a major public health problem because it is a risk factor in the development of metabolic complications (diabetes, cardiovascular diseases, etc.). It is a multi-factorial disorder. In addition to genetic predispositions and a life style that combines overeating with lack of exercise, there is a great volume of proof to suggest that contaminants, particularly in the food we eat, are responsible for the obesity epidemic and the resulting metabolic changes.

Researchers have put forward the hypothesis that contaminants in food could worsen certain metabolic problems already caused by eating an over-rich or a high-fat diet.

In this study, the researchers fed mice a high-fat diet (already a health risk), to which low doses of contaminants had been added. They were given this diet throughout their lives. Their mother had been nourished with this diet prior to their birth and during the gestation and lactation periods. Therefore, they suffered chronic exposure to this diet.

Two environmentally persistent contaminants (dioxin and PCB) and two non-persistent contaminants (phtalate and bisphenol A) were added to the high-fat (obesogenic) diet of the mice. The doses g
'/>"/>

Contact: Brigitte Le Magueresse Battistoni
brigitte.lemagueresse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
2. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
3. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
4. New UC Santa Barbara-based project to study contaminants in urban water environment
5. Gum disease found to worsen infection in animal model of AIDS
6. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
7. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
8. Formula-feeding linked to metabolic stress and increased risk of later disease
9. Grape intake may protect against metabolic syndrome-related organ damage
10. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
11. FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Apr. 27, 2015 Profile Solutions, Inc. (OTC: ... security systems is pleased to announce that Dr ... consultant and member of its scientific advisory board. ... as a thought leader in technology-enhanced learning models. He ... and has published studies and books focused on online ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... Earth, their altitude isn,t the only thing that dropstheir ... hypotension, occurs in up to half of those astronauts ... nearly all astronauts after long-term missions (four to six ... FASEB Journal ( http://www.fasebj.org ) solves the ...
... on the banks of the Elbe are not a common ... part of European wildlife, when mega-fauna such as woolly mammoths ... in Boreas , believe that the changing climate during ... to pygmy sizes before driving them to warmer climes. ...
... Copenhagen, Denmark Data publishers should have the option ... to a discussion paper commissioned by the Global Biodiversity ... a set of recommendations made by Mark Costello and ... Rights in advancing biodiversity data publication , freely ...
Cached Biology News:Why astronauts experience low blood pressure after returning to Earth from space 2Did the changing climate shrink Europe's ancient hippos? 2Peer review option proposed for biodiversity data 2
(Date:5/1/2015)... Md. and RESEARCH TRIANGLE PARK, N.C. ... UTHR ) announced today that Roger Jeffs , ... provide an overview and update on the company,s business at ... in Boston, Massachusetts . The ... 3:30 PM Eastern Time, and can be accessed via a ...
(Date:4/30/2015)... WARREN, N.J. , April 30, 2015  Roka ... company focused on providing advanced testing solutions for the ... financial results for the first quarter of 2015 on ... markets. Roka Bioscience will also host a ... 7, 2015 to discuss its first quarter financial results. ...
(Date:4/30/2015)... South San Francisco, CA (PRWEB) April 30, 2015 ... revenues for the first quarter of 2015 were $4.4 million, ... The net loss for the first quarter was $8.9 ... compared to a net loss for the same period in ... diluted share. As of March 31, 2015, cash, cash equivalents ...
(Date:4/30/2015)... Nitto Avecia, a leading biotechnology manufacturer and ... production capability to serve biotechnology pharmaceutical clients. A ... continues to drive Nitto Avecia to enhance synthesis ... , In Fall 2014, Nitto Avecia first ... its Milford, MA facility, which is recognized as ...
Breaking Biology Technology:Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... Support of Eradicating ,Drive-Through, ... to, Recuperate for at Least 48 Hours in the Hospital Following ... ... 18 "Desperate Housewives",star Marcia Cross will join Lifetime, Senator Landrieu (D-LA) ...
... a world leader in clinical,solutions for radiation therapy ... Elekta technology to implement clinical treatments with,Volumetric Modulated ... of,VMAT in Europe, the way has been cleared ... General Hospital Vienna in Austria to treat cancer ...
... Jan. 18 Derma Sciences, Inc.,(OTC Bulletin Board: DSCI), ... has increased its direct-sales staff significantly, based on a,number ... markets. The,company, which had only two direct salespersons in ... move to 21 by 2009. The increase is a ...
Cached Biology Technology:Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 2Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 3Elekta Announces First Two Clinical Sites Using VMAT Cancer Treatment Capability 2Elekta Announces First Two Clinical Sites Using VMAT Cancer Treatment Capability 3Derma Sciences Expands Direct Sales Force for Advanced Wound Care, Looks to Double Again in 2008 2Derma Sciences Expands Direct Sales Force for Advanced Wound Care, Looks to Double Again in 2008 3
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
PPIF Antibody...
Rabbit polyclonal to FLIP ( Abpromise for all tested applications). entrezGeneID: 8837 SwissProtID: O15519...
Biology Products: