Navigation Links
Food contaminants worsen metabolic problems in obese mice
Date:6/27/2013

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit (U1060 Laboratoire de recherche en cardiovasculaire, mtabolisme, diabtologie et nutrition Inserm/Inra/Universit Lyon 1) introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

The results show that metabolic changes occur in these mice, but that the effects differ depending on the gender. Females appeared to be more affected. Their obesity-induced glucose intolerance worsened and their estrogen pathway was altered.

These works have been published in the review Faseb Journal.

Obesity is a major public health problem because it is a risk factor in the development of metabolic complications (diabetes, cardiovascular diseases, etc.). It is a multi-factorial disorder. In addition to genetic predispositions and a life style that combines overeating with lack of exercise, there is a great volume of proof to suggest that contaminants, particularly in the food we eat, are responsible for the obesity epidemic and the resulting metabolic changes.

Researchers have put forward the hypothesis that contaminants in food could worsen certain metabolic problems already caused by eating an over-rich or a high-fat diet.

In this study, the researchers fed mice a high-fat diet (already a health risk), to which low doses of contaminants had been added. They were given this diet throughout their lives. Their mother had been nourished with this diet prior to their birth and during the gestation and lactation periods. Therefore, they suffered chronic exposure to this diet.

Two environmentally persistent contaminants (dioxin and PCB) and two non-persistent contaminants (phtalate and bisphenol A) were added to the high-fat (obesogenic) diet of the mice. The doses given were low, normally considered not to have any health impacts. These products were chosen because they are present in human food and because they are known to trigger endocrine disruption. In parallel, a control group of mice was fed with the same obesogenic diet, but without added contaminants.

The researchers then ran glucose tolerance and insulin sensitivity tests. They measured the livers for lipid accumulation and the expression of certain genes that play key roles in the metabolism of the adult mice.

The results show that the effects are highly dependent on the gender of the animal.

Male and female: different effects

In the females fed with a high-fat diet, the addition of contaminants worsened the glucose intolerance and altered the estrogen pathway. In males, it altered the cholesterol and lipid metabolism. There was no change in weight between the exposed mice and the unexposed mice.

The researchers pursued the hypothesis that there was a connection between the observed glucose intolerance and the alteration in the estrogen signaling in exposed females. It is well known that estrogens protect against metabolic disorders. In other words, these works suggest that in obese females, exposure to food contaminants could lower the protection level that estrogens provide against metabolic disorders.

"With this study, we have succeeded in providing proof-of-concept that low doses of contaminants, even at levels normally considered to be without health impacts in humans, do in fact affect humans when subjected to chronic exposure, and when the contaminants are combined with a high-calorie diet" points out Brigitte Le Magueresse Battistoni.


'/>"/>

Contact: Brigitte Le Magueresse Battistoni
brigitte.lemagueresse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related biology news :

1. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
2. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
3. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
4. New UC Santa Barbara-based project to study contaminants in urban water environment
5. Gum disease found to worsen infection in animal model of AIDS
6. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
7. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
8. Formula-feeding linked to metabolic stress and increased risk of later disease
9. Grape intake may protect against metabolic syndrome-related organ damage
10. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
11. FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... Paris Police Prefecture ... solution to ensure the safety of people and operations in ... major tournament Teleste, an international technology group specialised ... today that its video security solution will be utilised by ... public safety across the country. The system roll-out is scheduled ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
(Date:6/23/2016)... ReportsnReports.com adds 2016 global ... pharmaceuticals section with historic and forecast data along ... Complete report on the Cell Culture ... companies and supported with 261 tables and figures ... The Global Cell Culture Media Industry ...
(Date:6/22/2016)... , June 22, 2016  According to ... next generation sequencing (NGS) market include significant efforts ... smaller sequencers.  More accessible and affordable sequencers, say ... growing demand for consumables including sample prep materials.  ... Market for Sample Preparation for Next Generation Sequencing ...
(Date:6/22/2016)... June 22, 2016   ViaCyte, Inc. , a ... cell-derived islet replacement therapy for the treatment of diabetes ... 2016 Annual Meeting.  ISSCR 2016, the Global Stem Cell ... Moscone West in San Francisco.    ... are as follows:Event: , Focus Session: Tools for Basic ...
Breaking Biology Technology: