Navigation Links
Following the sugar right from the start
Date:5/28/2010

e Proceedings of the National Academy of Science (PNAS) that describes this latest glycan imaging research. The paper is titled "Visualizing enveloping layer glycans during zebrafish early embryogenesis." Co-authoring the paper with Bertozzi were graduate students Jeremy Baskin, Karen Dehnert and Scott Laughlin, and Sharon Amacher, Associate Professor of Molecular and Cell Biology at UC Berkeley.

Embryogenesis is the process by which a fertilized egg develops into a fetus. It starts with a single zygote cell that multiplies through rapid division (mitosis) into stem cells that subsequently differentiate into the specific types of cells that make up organs and tissues. Biologists need non-invasive imaging techniques to capture in detail such developments at the molecular as well as the cellular levels. Glycans play a central role in the signaling that takes place between cells during embryogenesis, which makes them appealing targets for molecular imaging. However, prior to Bertozzi's research, glycans were difficult to visualize using the standard tools of molecular imaging.

In 2007, Bertozzi and her research group announced the first copper-free variant of a chemical reaction known as "click chemistry," one of the most proficient methods for attaching probes to biological molecules. Conventional click chemistry requires a copper catalyst to accelerate the reaction of alkynes with azides - functional groups featuring three nitrogen atoms that can be integrated into biomolecules by metabolic labeling. However, because of copper's toxicity, the original click chemistry reactions could only be used on fixed cells or cells in a test-tube. Bertozzi and her group extended click chemistry to living cells and organisms by developing a difluorinated cyclooctyne or DIFO reagent that reacts with azides at physiological temperatures, eliminating the need for the toxic catalyst.

"It is a two-step chemical strategy for labeling glycans with imagi
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Ecologist finds dire devastation of snake species following floods of 93, 95
2. LSU professor studies army-ant-following birds
3. Researchers take first steps towards spinal cord reconstruction following injury
4. MNI researchers locate neurological basis of depression following sports concussion
5. When following the leader can lead into the jaws of death
6. Following traumatic brain injury, balanced nutrition saves lives
7. Researchers block damage to fetal brain following maternal alcohol consumption
8. Following the leader can be a drag, according to students research on flapping flags
9. Following the dietary guidelines may slow heart disease in women
10. Study finds women slightly more likely to die than men in the 30 days following a heart attack
11. New study finds way to stop excessive bone growth following trauma or surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Following the sugar right from the start
(Date:12/19/2014)... , Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ...
(Date:12/17/2014)... SM announced today its completion of a Good ... current U.S. Food and Drug Administration (FDA) regulations. This ... smart phone application trials utilizing the highest principles for ... determined to improve global healthcare access, quality, and delivery ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally transforming the ... at international borders. Over the past decade, ePassports, biometric ... to self process through border control via eGates and ... of airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... of functional, stable blood vessels at the site of ... the Georgia Institute of Technology have been able to ... "This study shows that bio-artificial materials are suitable ... on the study Andrs Garca, professor and Woodruff Faculty ...
... , , MILPITAS, Calif., Dec. 21 Cermetek Microelectronics, ... V.22bis modem module (2400 bits per second), is the first ... medical equipment safety. Cermetek has targeted the CH24606 as a ... for less than $15 in 1000 piece quantities. , Aside ...
... supposedly used it to guide the construction the Pyramids. The ... on it. Fictional Harvard symbologist Robert Langdon tried to unravel ... "It" is the golden ratio, a geometric proportion that ... the eye and has been the root of countless mysteries ...
Cached Biology News:Bioengineered materials promote the growth of functional vasculature, new study shows 2Bioengineered materials promote the growth of functional vasculature, new study shows 3Cermetek Introduces Medically Approved Modem Module 2Mystery of golden ratio explained 2
(Date:1/22/2015)... Davis, California (PRWEB) January 22, 2015 ... of Accelerator Mass Spectrometry (AMS) services to the pharmaceutical ... PhD has joined the company in the position of ... 30 years of broad and valuable experience in drug ...
(Date:1/22/2015)... January 21, 2015 Cambridge Semantics, the leading ... today announced that 2014 was a record-breaking year across the ... of the Anzo Smart Data Platform and our Smart Data ... insights from diverse data which led to record growth for ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... , SAN DIEGO, Sept. 3 Gen-Probe Incorporated (Nasdaq: ... conferences: , , , Baird,s 2009 Health ... , Thomas Weisel Partners, Healthcare Conference 2009 in Boston at ... Stanley Global Healthcare Unplugged Conference in New York at 8:35 a.m. ET on September ...
... ... detection, diagnostics capabilities , ... Argonne, IL (PRWEB) September 3, 2009 -- Researchers at the ... improve the stability of antibodies. The technique could lead to better biosensors, disease ...
... NEW YORK, Sept. 3 Reportlinker.com announces that a new market research ... Proteomics: Technologies and Global Markets , , ... REPORT HIGHLIGHTS , , * ... in 2008 to an estimated $7.9 billion in 2009 and $19.4 billion ...
Cached Biology Technology:Gen-Probe to Webcast Four Upcoming Investor Presentations 2Argonne Researchers Develop Method that Aims to Stabilize Antibodies 2Argonne Researchers Develop Method that Aims to Stabilize Antibodies 3Argonne Researchers Develop Method that Aims to Stabilize Antibodies 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 2Reportlinker Adds Proteomics: Technologies and Global Markets Report 3Reportlinker Adds Proteomics: Technologies and Global Markets Report 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 5Reportlinker Adds Proteomics: Technologies and Global Markets Report 6Reportlinker Adds Proteomics: Technologies and Global Markets Report 7Reportlinker Adds Proteomics: Technologies and Global Markets Report 8Reportlinker Adds Proteomics: Technologies and Global Markets Report 9Reportlinker Adds Proteomics: Technologies and Global Markets Report 10Reportlinker Adds Proteomics: Technologies and Global Markets Report 11Reportlinker Adds Proteomics: Technologies and Global Markets Report 12Reportlinker Adds Proteomics: Technologies and Global Markets Report 13Reportlinker Adds Proteomics: Technologies and Global Markets Report 14Reportlinker Adds Proteomics: Technologies and Global Markets Report 15Reportlinker Adds Proteomics: Technologies and Global Markets Report 16Reportlinker Adds Proteomics: Technologies and Global Markets Report 17Reportlinker Adds Proteomics: Technologies and Global Markets Report 18Reportlinker Adds Proteomics: Technologies and Global Markets Report 19Reportlinker Adds Proteomics: Technologies and Global Markets Report 20Reportlinker Adds Proteomics: Technologies and Global Markets Report 21
... T1 Thermocycler provides high speed and excellent ... with a TGradient Thermocycler can be run ... with a silver block for 48 or ... well plates or in-situ applications are available. ...
SDS-OutT SDS Precipitation Reagent...
Designed for use with the Agencourt SprintPrep 384 kit and all MCPrep reagent kits. Used with flat bottom 96-well microplates such as deep well plates used to culture bacteria....
... Ideal for staining westerns and includes stickers ... Pour spouts in each corner facilitate pouring ... be used for identification. Lid is designed ... for staining several gels simultaneously. Lid also ...
Biology Products: