Navigation Links
Folate prevents alcohol-induced congenital heart defects in mice
Date:5/24/2010

.2 mg/kg). A third control group ate a normal folate-supplemented diet (3.3 mg/kg) determined to maintain the general health of the pregnant mice, but not to rescue embryos from birth defects.

During the first week of pregnancy, the mice in all three groups were then administered injections of alcohol simulating a single binge drinking event in humans.

Following this alcohol exposure, Doppler ultrasound confirmed that 87 percent of the embryos of pregnant mice in the third group those not receiving folate supplementation beyond what was present in their normal diets had developed heart valve defects. The affected embryos were also smaller in size and their heart muscle walls appeared thinner.

Between days 15 and 16 of pregnancy in the mice equal to 56 days of gestation in humans -- ultrasound also showed that the high-folate diet protected heart valve development against lasting defects and restored heart function and embryonic size to near-normal levels. The moderate-folate diet provided only partial protection; in this group 58 percent of the mouse embryos developed heart valves that functioned abnormally, with a back flow of blood.

The researchers suggest that folate fortification may be most effective at preventing heart birth defects when administered at significantly higher levels than the doses currently recommended to prevent pregnancy complications -- both in normal women (0.4 milligrams recommended daily) and even in women who have delivered an infant with a spinal birth defect (4 milligrams daily). Although higher folate levels did not cause adverse side effects in the pregnant mice, Dr. Linask notes, the safety and effectiveness of higher doses must be proven with human trials.

The heart is the first organ to form and function during embryonic development of vertebrates. The USF researchers suggest that folate supplementation thwarts alcohol's damaging effect on an important early signaling pathway
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Attention-deficit/hyperactivity problems associated with low folate levels in pregnant women
2. SNPs affect folate metabolism in study of Puerto-Rican adults
3. Vitamin B-12 function may be diminished by excessive folate
4. Folate mystery finally solved
5. Yale researchers may have uncovered the mechanism by which progesterone prevents preterm birth
6. Tumor suppressor p53 prevents cancer progression in cells with missegregated chromosomes
7. New mechanism explains how the body prevents formation of blood vessels
8. Novel antibody prevents infection by hepatitis C virus
9. Drug prevents seizure progression in model of epilepsy
10. Sexual harassment from males prevents female bonding, says study
11. Targeted drug therapy prevents exercise-induced arrhythmias
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Athens, Ga. An international team of scientists including researchers ... Brassica napus commonly known as canolain the journal ... of the plant, which is used widely in farming and ... and its native Europe, but the winter crop is increasingly ... for its naturally low levels of saturated fat and rich ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... darkness use a previously unknown process for harvesting energy ... by a Penn State University scientist has discovered. The ... improving plant growth, harvesting energy from the Sun, and ... Erie and other lakes worldwide. A paper describing the ... Express edition of the journal Science on ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3
... findings about life in the heart of Yellowstone National ... years of Montana State University research. The book ... Sixteen Years of Integrated Field Studies" covers many of ... attention, said editor and MSU ecologist Robert A. Garrott. ...
... role in the disparity between the numbers of African ... the disease. A study by researchers at the Johns ... disparity was substantially reduced when comparing groups of African ... The results are published in the November 2008 print ...
... | Union County New Mexico is a landscape of striking ... cone volcanoes and mesas preserved by basalt, part of the ... is the youngest volcano in the field. The cone rises ... m above sea level. The base of the volcano is ...
Cached Biology News:New book covers 16 years of MSU research in Yellowstone 2New book covers 16 years of MSU research in Yellowstone 3Hypertension disparity linked to environment 2Scientists map soils on an extinct American volcano 2
(Date:8/21/2014)... August 21, 2014 Gallus ... contract development and manufacturing organization (CMO) announced today ... Inc., an oncology company focused on the development ... to manufacture the anti-prostate specific membrane antigen (PSMA) ... candidate. Under the agreement the antibody will ...
(Date:8/21/2014)... On Wednesday of last week RENU 28, the ... molecules, became available for purchase in Australia and New Zealand, ... RENU 28 works is, if you think about the definition ... of cellular renewal within your body. If you think about ... of cellular renewal. What RENU 28 does is it works ...
(Date:8/20/2014)... analysis of patented university inventions licensed to biotechnology ... to commercialization. To open these roadblocks, the researchers ... during the discovery stage could lead to faster ... frequently derived from discoveries made in university laboratories ... known during clinical trials, which have a high ...
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3RENU 28 Skin Care Now Available in Australia and New Zealand 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Seeing a molecule breathe 2
... PharmaVentures announced today that it was delighted ... US and Canada as Merck & Co) to secure its ... Nottingham and Roslin BioCentre, for the former MSD research facility ... working between MSD, the Scottish Life Sciences community and the ...
... 17, 2012  Cepheid (Nasdaq: CPHD ) today ... the position of Senior Vice President, Human Resources, effective ... Cepheid from Verigy, Inc., a wholly owned subsidiary of ... Vice President of Human Resources.  Prior to Verigy, Mr. ...
... from a Nobel Laureate. Find out how major discoveries ... policy, education, and research in other countries. The iBioSeminars ... online, on-demand, and for free. iBioSeminars ... biology seminars given by the world,s leading researchers. The ...
Cached Biology Technology:PharmaVentures Helps Secure Investor for Former MSD Research Site 2Cepheid Welcomes Senior Vice President of Human Resources 2iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists 2
HLA-DRbeta (DA2)...
... to Cytokeratin 5 / 6 Cytokeratin ... weight, basic type of cytokeratin expressed in ... layers of stratified epithelia as well as ... cells and mesothelioma. Cytokeratin 6 (56 kD) ...
...
Aldolase A (N-15)...
Biology Products: