Navigation Links
Focus on glaucoma origins continues path toward potential cure
Date:1/17/2012

Glaucoma is the second leading cause of blindness. Nearly 4 million Americans have the disorder, which affects 70 million worldwide. There is no cure and no early symptoms. Once vision is lost, it's permanent.

New findings at Georgia Tech, published in January during Glaucoma Awareness Month, explore one of the many molecular origins of glaucoma and advance research dedicated to fighting the disease.

Glaucoma is typically triggered when fluid is unable to circulate freely through the eye's trabecular meshwork (TM) tissue. Intraocular pressure rises and damages the retina and optic nerve, which causes vision loss. In certain cases of glaucoma, this blockage results from a build-up of the protein myocilin. Georgia Tech Chemistry and Biochemistry Assistant Professor Raquel Lieberman focused on examining the structural properties of these myocilin deposits.

"We were surprised to discover that both genetically defected as well as normal, or wild-type (WT), myocilin are readily triggered to produce very stable fibrous residue containing a pathogenic material called amyloid," said Lieberman, whose work was published in the most recent Journal of Molecular Biology.

Amyloid formation, in which a protein is converted from its normal form into fibers, is recognized as a major contributor to numerous non-ocular disorders, including Alzheimer's, certain forms of diabetes and Mad Cow disease (in cattle). Scientists are currently studying ways to destroy amyloid fibrils as an option for treating these diseases. Further research, based on Lieberman's findings, could potentially result in drugs that prevent or stop myocilin amyloid formation or destroy existing fibrils in glaucoma patients.

Until this point, amyloids linked to glaucoma had been restricted to the retinal area. In those cases, amyloids kill retina cells, leading to vision loss, but don't affect intraocular pressure.

"The amyloid-containing myocili
'/>"/>

Contact: Jason Maderer
maderer@gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Lung cancer conference to focus on new diagnostic techniques, potential treatments
2. Predictive health symposium will focus on human microbiome
3. Conservationists call for increased focus on coastal ecosystems
4. New book from NJIT professor focuses on art, science and evolution
5. Focus on fats
6. First NIH-funded personalized drug development center in US will focus on muscle disease
7. Fate of lakes focus of international meeting in Sunapee, N.H.
8. Journal focuses on Savannah River National Labratory, Chernobyl Laboratory collaboration
9. Researchers develop optimal algorithm for determining focus error in eyes and cameras
10. International pharmacogenomics conference to focus on better drug treatment based on genetics
11. October 2011 conference focuses on the role of gender in cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Focus on glaucoma origins continues path toward potential cure
(Date:11/4/2014)... LAKE CITY, Nov. 5, 2014 – University of Utah ... enzymes to help jet fuel produce electricity without needing ... be used to power portable electronics, off-grid power and ... online today in the American Chemical Society journal ... electricity through a chemical reaction between a fuel and ...
(Date:11/4/2014)...   3D scanner developer targets ... Fuel3D , a developer of 3D scanning solutions, today announced ... (£4 million). This funding builds on the company,s initial $2.6 ... the way for the commercial launch of the company,s consumer ... led by Chimera Partners and will be used to ramp-up ...
(Date:11/3/2014)... LOS ANGELES , Nov. 3, 2014 /PRNewswire/ ... California -based life sciences company focused on ... eTNS system for the treatment of neurological ... Institute of Industrial Property has issued a Notice ... The patent application is co-owned by NeuroSigma and ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... (June 21, 2012) Autism Speaks, the world,s leading ... of new research grants totaling nearly $2.9 million in ... extraordinarily proud of Autism Speaks, not only for funding ... avenues to understanding autism," said Autism Speaks Co-founder Bob ...
... ocean infrastructure development to tap energy sources such as ... pile driving, the practice of pounding long, hollow steel ... energy turbines and other structures. But pile driving creates ... marine animals., Many scientists and regulators have assumed that ...
... world are preparing to address the urgent need to ... biodiversity. The Global Biodiversity Informatics Conference (GBIC) will ... and policy in Copenhagen, Denmark from 2-4 July. ... strategy and roadmap to make best use of the ...
Cached Biology News:Autism Speaks awards nearly $2.9 million to fund autism research 2Autism Speaks awards nearly $2.9 million to fund autism research 3Autism Speaks awards nearly $2.9 million to fund autism research 4Turning down the dial: Ocean energy development with less sound 2Turning down the dial: Ocean energy development with less sound 3Turning down the dial: Ocean energy development with less sound 4A new vision for harnessing data about life on Earth 2
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the ... Awards for outstanding creative achievement by its marketing and ... the organization’s top honor, in the Branding category for ... April of this year. The event showcased top speakers ... was awarded a Gold MarCom Award in the Special ...
(Date:11/26/2014)... Boston, MA (PRWEB) November 26, 2014 ... and collaboration company is proud to announce that Darren ... Development and Sales. Darren will drive the ... and positive customer experience. , Darren brings ... He has held key roles in channel operations, from ...
(Date:11/26/2014)... MINNEAPOLIS , Nov. 25, 2014 Bio-Techne ... it has appointed Robert Gavin to serve ... of the Protein Platforms Division.  Mr. Gavin will be ... business segment, which includes the ProteinSimple business acquired in ... San Jose, California -based ProteinSimple ...
(Date:11/24/2014)... DUBAI , UAE, November 24, 2014 ... prestigious "Sheikh Hamdan Bin Rashid Al Maktoum Awards for ... in Dubai, United Arab Emirates , ... http://photos.prnewswire.com/prnh/20141124/717861 ) , The Carter Center ... Medical Services is actively involved in numerous programs that ...
Breaking Biology Technology:Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2SoundConnect Appoints Director of Channel Development & Sales 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Five US Winners Among Recipients of Hamdan Medical Awards 2
... 4, 2011 InterMune, Inc. (NASDAQ: ITMN ) ... President of InterMune, will present at the Bank of America ... on May 11, 2011, at 1:00 p.m. PDT.   ... investors and other interested parties may log on to the ...
... a letter from Nicusa Capital urging BioClinica (Nasdaq: BIOC ... from incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy: ... Chairman of the Board BioClinica, Inc. 826 Newtown-Yardley Rd. Newtown, PA ... of BioClinica: As of May 4, 2011, Nicusa owns ...
... Inc. (Nasdaq: NXTM ), a leading manufacturer ... the first quarter of 2011 ended March  31, 2011, ... guidance range. (Logo: http://photos.prnewswire.com/prnh/20110503/MM94799LOGO) Net ... to a record $50.6 million compared with revenue of ...
Cached Biology Technology:This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 2This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 3This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 4This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 5NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 2NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 3NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 4NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 5NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 6NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 7
Recorder REC-111 single-channel, 1. Category: Chromatography Systems & Accessories, Systems....
... for when you need to make your strain ... efficiency. Our services for preparing competent cells are ... custom competent cell service offers: ... Fast turnaround Quality control performance testing ...
Fast, sensitive quantitation of total MEK 1/2 concentration....
Argon Calibration Source...
Biology Products: