Navigation Links
Fly studies reveal immune cell responses to tumor and tissue damage
Date:9/16/2008

September 17, 2008, Cambridge, UK
Knee scrapes and tumor growth might have more in common than you think.

The idea that tumor growth triggers the same immune response as a cut or wound was once a highly controversial notion. However, increasing evidence supports the idea that the same cellular mechanisms which heal a skinned knee might also have a role in preventing the growth of tumors. A report published today in Disease Models & Mechanisms (DMM), dmm.biologists.org, now reveals more details about the common links between tumor growth and tissue damage in flies.

Tian Xu and colleagues at the Yale University School of Medicine examined the activity of hemocytes, a type of immune cell, in response to genetically-induced tumor growth in the fruit fly Drosophila. They found that tumors caused circulating hemocytes to replicate and adhere to the tumor surface, thereby limiting tumor growth. They compared this hemocyte response to cell activity in normal flies which were wounded and had tissue damage. Hemocyte profileration in these flies occurred just as in the tumor-producing fly. Furthermore, by examining the molecular signals triggered in the immune response, Xu's team discovered that the tumor's physical disruption and damage of nearby tissues at least in part triggered the hemocyte response.

This study not only supports previously reported links between immune responses and cancer, but also identifies key pathways in the fly's immune response to tumor growth and tissue disruption. These pathways are likewise shared in humans, demonstrating that the fly can be used to study potential drug targets which could enhance the body's natural immune response against cancer.


'/>"/>

Contact: Nick Birch
nick@biologists.com
44-012-234-26164
The Company of Biologists
Source:Eurekalert

Page: 1

Related biology news :

1. New studies on the Mediterranean diet confirm its effectiveness for chronic disease prevention
2. Cardiac cell transplant studies show promise in cardiac tissue repair
3. Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
4. Treatment corrects severe insulin imbalance in animal studies
5. During Olympics, Cornells Max Zhang studies air-quality in Beijing
6. New studies predict record land grab as demand soars for new sources of food, energy and wood fiber
7. Automated microfluidic device reduces time to screen small organisms for genetic studies
8. NJIT applauds students for studies on brain injury, glaucoma and more
9. Prof. David Kisailus studies engineering and invention on the half-shell
10. Carnegie Mellon studies how climate change impacts food production
11. Antioxidant users dont live longer, analysis of studies concludes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)...  Aware, Inc. (NASDAQ: AWRE), a leading supplier of ... Moberg has resigned, effective March 3, 2017, as ... and Treasurer of Aware citing a desire to retire.  ... of the Board of Directors of Aware. ... and co-President, General Counsel has been named Chief Executive ...
(Date:2/26/2017)... Feb. 25, 2017  Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring, announces ... Reentry. "Too often, too many offenders ... county jails are trying to tackle this ongoing ... friends and family members. While significant steps are underway, ...
(Date:2/16/2017)... Feb. 16, 2017  Genos, a community for ... it has received Laboratory Accreditation from the College ... presented to laboratories that meet stringent requirements around ... rigorous processes. "Genos is committed to ... practices. We,re honored to be receiving CAP accreditation," ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... MILFORD, Mass. , March 23, 2017 ... leading partner to global in vitro diagnostics ... launch of the industry,s first multiplexed ... inherited disease testing by next-generation sequencing ... materials were developed with input from industry ...
(Date:3/23/2017)... ... March 23, 2017 , ... Ellen Matloff, president ... Technology Council (CTC) as a 2017 Women of Innovation® finalist. Matloff will be ... Awards Dinner. , The dinner recognizes women accomplished in science, technology, engineering and ...
(Date:3/23/2017)... New York , March 23, 2017 ... blood plasma products and derivatives market is fragmented due to the presence ... players, such as Proliant, Thermo Fisher , and Sigma-Aldrich, compete ... leader, these three companies, collectively, held more than 76% of this ... ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... solutions, today announced the hire of Dr. Sigmund “Sig” Floyd as Vice President ... strategic partnerships and joint development activities. , “Dr. Floyd’s career has spanned 30 ...
Breaking Biology Technology: