Navigation Links
'Fly guy' makes memory breakthrough
Date:12/10/2008

Dr. Francois Bolduc keeps more than 300,000 fruit flies in a basement laboratory, where he manipulates their genes and then tests their mental abilities. He's called the "fly guy," and he may sound like a comic book villain, but Bolduc is no mad scientist.

A new recruit to the University of Alberta's Faculty of Medicine & Dentistry, Bolduc has shown that genetically disrupting a specific gene called FMR1 in a fruit fly's brain will wipe out its long-term memory. Bolduc has also found a class of drugs that helps fruit flies with this disrupted gene to regain their memories. The news is significant for humans, because FMR1 may malfunction in people with intellectual disabilities like Fragile X syndrome, and there are currently no clinically available treatments.

Fragile X syndrome is the most common cause of genetically defined developmental delays in humans, affecting 1 in 4,000 males and 1 in 8,000 females. Children with Fragile X syndrome may have learning and memory problems, epilepsy and autism.

"We know that 87 per cent of the genes found in human mental retardation have homologs in fruit flies, so we're confident that we're on to something here," said Bolduc, whose research was recently published in Nature Neuroscience.

Bolduc's test of long-term memory in fruit flies began by exposing them to two smells in succession that were different but "equally repulsive" to the flies. One of the smells was paired to a foot shock, and the other was benign. From this, the flies learn to avoid the odor that leads to a shock, even in the absence of a future shock. This memory lasts for about a weekone-fifth of a lifetime to an average fruit fly.

In his long-term memory experiment, Bolduc found just 10 per cent of the fruit flies without the FMR1 gene avoided the smell that led to a shock, while 50 per cent of the normal flies knew enough to steer clear of it.

"The evidence clearly showed that the flies
'/>"/>

Contact: Lindsay Elleker
lindsay.elleker@ualberta.ca
780-492-0647
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. New drug makes weight loss safer
2. How mother of thousands makes plantlets
3. For honey bee queens, multiple mating makes a difference
4. Scientists spy enzyme that makes us unique
5. Thinking makes it so: Science extends reach of prosthetic arms
6. Choosing dry or wet food for cats makes little difference
7. Technique controls nanoparticle size, makes large numbers
8. Decoy makes sitting duck of superbugs
9. Case researcher in RNA biology makes waves by challenging current thinking
10. New process makes nanofibers in complex shapes and unlimited lengths
11. Diabetes makes it hard for blood vessels to relax
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 2015 To bolster its efforts and commitment to ... today the addition of two new team members. ... and David Raviv will act as head of ... commitment to providing the most secure solutions for the enterprise ... Layer 7 Technologies, a provider of security and management products, ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... found a mechanism that naturally shuts down cellulose production ... turned on may be key to enhancing biomass production ... botany and plant pathology, said that small-interfering RNAs (siRNAs) ... off genes involved in primary cell wall growth in ...
... Finnish scientists have reported a breakthrough in the attempts ... discovered disturbances in lipid and amino acid metabolism in ... known as juvenile diabetes. The alterations preceded the autoimmune ... new approaches for prediction and prevention of type 1 ...
... is available in French . , ... intelligent design. An evolutionary geneticist from the Universit de ... Lyon and Montpellier, have published a ground-breaking study that ... LUCA (Last Universal Common Ancestor). Their findings, presented in ...
Cached Biology News:Researchers find nature's shut-off switch for cellulose production 2New scientific knowledge on juvenile diabetes 2New scientific knowledge on juvenile diabetes 3Earth's original ancestor was LUCA, not Adam nor Eve 2
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... NY (PRWEB) , ... June 30, 2015 , ... This ... and Perkin Elmer machines. Featuring 12 distinct peaks, the WAV-8 is the world’s ... machine is in spec deep into the NIR range. Previous spectrophotometer calibration standards, such ...
(Date:6/29/2015)... ... June 29, 2015 , ... MediVet Biologics today announced ... agreement, MediVet will acquire the rights to a portfolio of cultures, products and ... development as a potential next-generation treatment for various musculoskeletal and internal medicine conditions ...
(Date:6/29/2015)... June 29, 2015 BioNano Genomics, Inc., the ... research institutes, announced today that a collaboration led by ... in the creation of the first comprehensive analysis of ... molecule methods for sequencing and genome mapping. This study, ... comprehensive analysis of the contiguous diploid human genome assembly ...
Breaking Biology Technology:New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 2BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 3
... An affiliate of,Phlo Corporation (OTC: PHLC) (the "Company") ... has now been expanded to the San,Francisco and ... counties and stretching to the Oregon border. ... Mollie,Stones Grocery in Palo Alto, Zanotto,s Grocery in ...
... 49%, Pre-Tax Net Income Up 42%, HARBIN, China, ... Bulletin Board: CKGT), a vertically integrated,grower, developer, manufacturer, and ... its report on Form 10QSB and reported its,unaudited results ... reported,are in U.S. dollars. The Company has achieved ...
... connected with potential Benitec HIV therapy, MELBOURNE, Australia, ... Memorandum of Understanding with California-based,CalbaTech, Inc. (OTC Bulletin Board: ... patients who may use the healthy adult (or "blood" ... collaborated with City of Hope, a biomedical research and,treatment ...
Cached Biology Technology:Phlo Affiliate Reports Expanded Coverage to Oregon Border 2China Kangtai Cactus Biotech Files 2nd Quarter 2007 10QSB and Announces Unaudited Quarterly Results 2China Kangtai Cactus Biotech Files 2nd Quarter 2007 10QSB and Announces Unaudited Quarterly Results 3Benitec MOU With CalbaTech, Inc. 2Benitec MOU With CalbaTech, Inc. 3Benitec MOU With CalbaTech, Inc. 4
with GlutaMAXIL-glutamine...
Request Info...
... ZMD.257. Immunogen: Synthetic peptide derived from ... Connexin 36 protein This peptide sequence ... generate another Zymed polyclonal Connexin 36 antibody ... mouse Connexin 36. Reactivity: Mouse (positive ...
Request Info...
Biology Products: