Navigation Links
'Fly guy' makes memory breakthrough
Date:12/10/2008

Dr. Francois Bolduc keeps more than 300,000 fruit flies in a basement laboratory, where he manipulates their genes and then tests their mental abilities. He's called the "fly guy," and he may sound like a comic book villain, but Bolduc is no mad scientist.

A new recruit to the University of Alberta's Faculty of Medicine & Dentistry, Bolduc has shown that genetically disrupting a specific gene called FMR1 in a fruit fly's brain will wipe out its long-term memory. Bolduc has also found a class of drugs that helps fruit flies with this disrupted gene to regain their memories. The news is significant for humans, because FMR1 may malfunction in people with intellectual disabilities like Fragile X syndrome, and there are currently no clinically available treatments.

Fragile X syndrome is the most common cause of genetically defined developmental delays in humans, affecting 1 in 4,000 males and 1 in 8,000 females. Children with Fragile X syndrome may have learning and memory problems, epilepsy and autism.

"We know that 87 per cent of the genes found in human mental retardation have homologs in fruit flies, so we're confident that we're on to something here," said Bolduc, whose research was recently published in Nature Neuroscience.

Bolduc's test of long-term memory in fruit flies began by exposing them to two smells in succession that were different but "equally repulsive" to the flies. One of the smells was paired to a foot shock, and the other was benign. From this, the flies learn to avoid the odor that leads to a shock, even in the absence of a future shock. This memory lasts for about a weekone-fifth of a lifetime to an average fruit fly.

In his long-term memory experiment, Bolduc found just 10 per cent of the fruit flies without the FMR1 gene avoided the smell that led to a shock, while 50 per cent of the normal flies knew enough to steer clear of it.

"The evidence clearly showed that the flies
'/>"/>

Contact: Lindsay Elleker
lindsay.elleker@ualberta.ca
780-492-0647
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. New drug makes weight loss safer
2. How mother of thousands makes plantlets
3. For honey bee queens, multiple mating makes a difference
4. Scientists spy enzyme that makes us unique
5. Thinking makes it so: Science extends reach of prosthetic arms
6. Choosing dry or wet food for cats makes little difference
7. Technique controls nanoparticle size, makes large numbers
8. Decoy makes sitting duck of superbugs
9. Case researcher in RNA biology makes waves by challenging current thinking
10. New process makes nanofibers in complex shapes and unlimited lengths
11. Diabetes makes it hard for blood vessels to relax
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 The Defense Logistics Agency is insourcing its ... counterfeit microcircuits from entering into its supply chain. ... anti-counterfeit initiative dubbed DNA marking. The capability will validate ... throughout the supply chain. The new quality control measures ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... women have twice the risk of preterm delivery than ... a new study by the Kaiser Permanente Division of ... University Press,s journal Human Reproduction on behalf ... The study found that pregnant women with symptoms ...
... Palm Vein Authentication Technology Integrates with,Citrix Password ... and,Compliance, SUNNYVALE, Calif., Oct. 22 ... supplier of innovative computer products including,hard disk ... that its PalmSecure LOGONDIRECTOR has been verified ...
... University, along with colleagues from the California Institute of ... other institutions, have unearthed crystalline magnetic fossils of a ... boundary of the Paleocene and Eocene epochs, some 55 ... in the Proceedings of the National Academy of ...
Cached Biology News:Depression during pregnancy can double risk of preterm delivery 2Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 2Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 3Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 4Earlier global warming produced a whole new form of life 2
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... Earlier this year in a June 24 ... Adult Stem Cell Technology Center, LLC ( ASCTC ) focused ... of adult tissue stem cells. His title “Asymmetric Self-Renewal ... the Future,” embodied the essence of his message to congress ...
(Date:12/24/2014)... 2014 According to Ross Selinger, President of ... ITRA Global, the national office market continues to be strong, ... is evidenced by the third quarter’s surprising 3.9% GDP, unemployment ... energy costs have held inflation down and the Fed is ...
(Date:12/24/2014)... (PRWEB) December 24, 2014 The report expects ... by 2019. It also provides a carefully analyzed data about ... the market. , Full Copy of Report @ http://bit.ly/1yUxy0T ... cell expansion will keep witnessing growth at an impressive CAGR ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... Care at Hahnemann among the Best in the Nation ... it has been granted Magnet(R) recognition by the American Nurses ... the highest levels of recognition a hospital or medical center ... hospitals in the country that have achieved this prestigious distinction. ...
... , , , WALTHAM, Mass., Dec. 16 Decision ... firms for pharmaceutical and healthcare issues, finds that, according ... and Abbott,s briakinumab (both interleukin inhibitors) will capture 22 ... drug market for moderate to severe psoriasis. Among these ...
... Looking ... for! Zap-CHO is a robust CHO cell culture media supplement that improves the growth ... Zap-CHO is an animal free, well defined and consistent recombinant CHO supplement. , ... Fort Collins, CO (PRWEB) ...
Cached Biology Technology:Hahnemann University Hospital Granted Magnet(R) Status 2Hahnemann University Hospital Granted Magnet(R) Status 3In 2012, Stelara and Briakinumab Will Capture 22 Percent of the Biologics Share in the Moderate to Severe Psoriasis Drug Market 2In 2012, Stelara and Briakinumab Will Capture 22 Percent of the Biologics Share in the Moderate to Severe Psoriasis Drug Market 3Online Video of InVitria's Zap-CHO Helps Scientists Maximize CHO Cell Culture Performance 2
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
...
...
... BioLegend, the Quansys Biosciences Q-Plex Array is ... cytokines/chemokines for human, mouse, and rat research. ... fully quantitative ELISA-based test where 4 distinct ... well of a 96-well plate in a ...
Biology Products: