Navigation Links
Fly cells flock together, follow the light
Date:6/18/2010

Scientists at Johns Hopkins report using a laser beam to activate a protein that makes a cluster of fruit fly cells act like a school of fish turning in social unison, following the lead of the one stimulated with light.

The study of this unexpected cell movement, reported May 16 in Nature Cell Biology, holds potential importance for understanding embryonic development, wound healing and tumor metastasis the process by which tumor cells acquire the ability to invade surrounding tissues and migrate long distances to colonize lymph nodes, bones and other distant organs.

The research dramatically demonstrates, the researchers say, the collective direction-sensing behavior of live cells in intact tissue, and a means of controlling protein behavior in a living organism by shining a focused beam of light precisely on the parts of cells where they want the protein to be active.

"Our little system in the fruit fly is an elegant example of cells behaving socially in their natural environment surrounded by other cells," says Denise Montell, Ph.D., a professor of biological chemistry and director of the Center for Cell Dynamics at the Johns Hopkins University School of Medicine. "You can't capture this behavior if you look at individual cells in a culture dish."

The "social" migrating behavior among a cluster of cells in the fly ovary surprised the research team, which was using a new laser light tool to manipulate protein activity.

"People tend to think of cancer as single cells breaking off from the tumor and migrating away," Montell says, but it's likely that this collective form of movement is important, at one phase or another, in the spread of tumors."

A better understanding of how and why cells move can facilitate the development of new treatments not only for cancer but other disorders characterized by aberrant cell behavior.

Developed in the laboratory of Klaus Hahn, Ph.D., Thurman
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... news release is available in German . ... as individuals prompt our fellow humans to behave socially? ... social dilemmas in game theory. Previous studies assumed that ... groups. Nonetheless, scientists from the Max Planck Institute for ... can exert an influence on the cooperative behaviour of ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... oil and gas production are well over recommended levels ... access journal Environmental Health . High levels of ... is the first to be based on community sampling ... be used to supplement official air-quality monitoring programs. , ... not readily flow to the surface. This is because ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... not all plants from the same species can be ... only prevent the exchange of genes between well-established species ... but also between varieties of one and the same ... if one wants to understand the origin of biodiversity. ...
... global inventory of farm animals showing many breeds of ... extinction, scientists from the Consultative Group on International Agricultural ... genebanks to conserve the sperm and ovaries of key ... An over-reliance on just a few breeds of ...
... clear nearly a century ago that many genes likely influence ... has followed in defining the myriad genes. Now an international ... a genetic variant associated with human height the first ... in the September 2 advance online edition of Nature Genetics, ...
Cached Biology News:How the plant immune system can drive the formation of new species 2How the plant immune system can drive the formation of new species 3Report: African, Asian, Latin American farm animals face extinction 2Report: African, Asian, Latin American farm animals face extinction 3Report: African, Asian, Latin American farm animals face extinction 4Genome study shines light on genetic link to height 2Genome study shines light on genetic link to height 3
(Date:10/30/2014)... 2014  Ardelyx, Inc. (NASDAQ: ARDX ... gastrointestinal and metabolic diseases, today announced that it ... Thursday, November 6, 2014. Following the announcement, the ... call and webcast at 4:30pm ET to review ... update. The live webcast can be ...
(Date:10/30/2014)... 30, 2014 SoundConnect , ... offers Office 365 end users the key to ... phone system by adding voice enablement and hybrid ... Lync Online, a communication tool that includes presence, ... hosted voice, O365 becomes a comprehensive unified communications ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Whitehouse Laboratories ... its ICH Stability Testing and Package Test Capacity. Responding ... centers on a dramatic increase in environmental chamber storage ... stability, storage and aging samples to be securely held ... this major capital expenditure has already taken place with ...
(Date:10/30/2014)... A new report, commissioned by BioCrossroads and ... in-depth look at Indiana,s capital ... two different time frames: 1993 to 2002 and 2003 ... opportunities for investment growth.  The Life Science Innovation ... gains in innovation dollars as well as an increase ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5
... 18 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: ... specializing in the manufacture,research, development, marketing and ... applied for listing approval on the Nasdaq ... milestone for China-Biotics, and we are committed,to ...
... 18 Swedish environmental technology,company SEKAB has signed ... its sustainability with LDC Bioenergia, a Brazilian ethanol,and ... group Louis Dreyfus., "The agreement safeguards supplies ... production chain for environmental and social,sustainability," says Anders ...
... a magnet that,s smaller than the head of a pin? ... of MRI technique to do just that. , The technique may ... doctors a new tool for studying the plaques in blood vessels ... In a recent issue of Physical Review Letters, the ...
Cached Biology Technology:China-Biotics, Inc. Files Application for Nasdaq Listing 2SEKAB Agreement: More Verified Ethanol to Europe 2New kind of MRI enables study of magnets for computer memory 2New kind of MRI enables study of magnets for computer memory 3
... harvesting of cells • Blade design minimizes ... the growth surface • Designed for use ... wrapped • Sterilized by gamma radiation and ... a new product number, created to easily ...
... single use spatulas have been designed to ... are for those interested in eliminating the ... Each spatula is individually packaged, RNase/DNase free, ... is a new product number, created to ...
... use with dishes and cell culture clusters. ... product number, created to easily match Cornings ... please order under the old Sigma-Aldrich number ... Comp Dim: blade L 1.9 cm handle ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
Biology Products: