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Flu's evolution strategy strikes perfect balance
Date:6/10/2010

he AIDS virus only has a few opportunities to replicate its genome in each infection cycle, its polymerases are highly error prone in order to generate sufficient mutations within its limited replication window. In contrast, the flu virus polymerases are high-fidelity enzymes they are accurate and not prone to error. Even without copious changes in genetic material, the flu's multiple replication strategy allows the virus to produce genomic mutations sufficient for viral evolution and host adaptation.

"Kim's team has developed some very important new methodology for studying the function of the flu polymerase that could easily result in the development of new antivirals or other methods to control influenza," said Treanor. "I think this research will stimulate a lot of additional research about the flu polymerase."


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Contact: Emily Butler
emily_butler@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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