Navigation Links
Fluorescent proteins illuminating biomedical research
Date:1/25/2009

s, computers, and highly sensitive digital cameras, scientists have been able to surmount the barriers of optical imaging. The first generation of these new imaging devices, collectively known as super-resolution (SR) fluorescence microscopes, were able to capture images as small as 15 to 20 nanometers the scale of single molecules. But this could be done only in non-living cells. The addition of PAFPs, more versatile versions of FPs, made it possible to do real-time SR fluorescence microscopy in living cells. Last month, Nature Methods selected SR fluorescence microscopy as the 2008 Method of the Year.

Dr. Verkhusha has developed a variety of PAFPs and FPs for use in imaging mammalian cells, expanding the applications of fluorescence microscopy. Among these are PAFPs that can be turned on and off with a pulse of light, FPs that can fluoresce in different colors, and FPs that have better resolution for deep-tissue imaging.

Most recently, Dr. Verkhusha developed a red PAFP called PAmCherry1, which has faster photoactivation, improved contrast, and better stability compared to other PAFPs of its type. "PAmCherry1 will allow improvements in several imaging techniques, notably two-color SR fluorescence microscopy, in which two different molecules or two biological processes can be viewed simultaneously in a single cell," explains Dr. Verkhusha. The findings were published today in the online version of Nature Methods.

Several studies have employed Dr. Verkhusha's PAFPs, revealing new insights into a variety of biological processes. For example, one of his PAFPs was used to capture the first nanoscale images of the orientation of molecules within biological structures. "Such images could be useful in studying protein-protein interactions, the growth and collapse of intracellular structures, and many other biological questions," says Dr. Verkhusha. The results were published in November 2008 in Nature Methods.'/>"/>

Contact: Michael Heller
mheller@aecom.yu.edu
718-430-4186
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
2. Fluorescent cells give early warning for eye disease
3. Fluorescent nano-barcodes could revolutionize diagnostics
4. Fantastic photographs of fluorescent fish
5. Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
8. Depression, aging, and proteins made by a virus may all play role in heart disease
9. New approach builds better proteins inside a computer
10. Legionnaires bacterial proteins work together to survive
11. Proteins pack tighter in crowded native state
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, ... fine-scale differences in genetic ancestry of individuals from across ... Since immigrants first arrived more than four hundred years ... served as a meeting place for peoples from different ... ongoing mixing of peoples with African, European, and American ...
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014 /PRNewswire-USNewswire/ ... a Good Clinical Practices (GCP) audit to confirm ... Administration (FDA) regulations. This accomplishment enables HITLAB to ... trials utilizing the highest principles for patient safety ... to improve global healthcare access, quality, and delivery ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... Medicine have enhanced our understanding of the mechanism by ... food is converted into the energy required by cells. ... how organisms synthesize their major form of chemical energy. ... of PLoS Biology . Cells use the ...
... Mont. -- Researchers at Montana State University have ... for treating antibiotic resistant infections, fungal infections and viral ... to study such compounds. The technologies are ... The first technology involves an existing clinical drug ...
... YORK and LEON, GUANAJUATO MEXICO, Aug. 18 Global ... and identity management market, announced today that it will ... Leon, Guanajuato, Mexico. Portoss, a Leon-based company, specializes in ... latest partnership between Portoss and the City of Leon ...
Cached Biology News:Mount Sinai researchers discover new mechanism behind cellular energy conversion 2Montana State University offers 6 new biomedical technologies for licensing 2Montana State University offers 6 new biomedical technologies for licensing 3Montana State University offers 6 new biomedical technologies for licensing 4Global Rainmakers Delivers World Class Iris Capability for Portoss 2Global Rainmakers Delivers World Class Iris Capability for Portoss 3
(Date:12/24/2014)... December 23, 2014 Earlier this year ... L. Sherley, director of the Adult Stem Cell Technology ... often overlooked and under appreciated unique property of adult ... Distributed Stem Cells: Misunderstood in the Past, Important for ... congress participants. He gave the address at the ...
(Date:12/24/2014)... Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for ... advancing knowledge and research in reproductive medicine. In ... a seat on the executive board and will have ... , Dr. Hill has actively supported ASRM since 1984 ...
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/22/2014)... Dec. 22, 2014   Synthetic Biologics, ... of pathogen-specific therapies for serious infections and ... microbiome, today announced positive topline safety and ... trial of SYN-004, the Company,s investigational oral ... Clostridium difficile (C. difficile) infection, antibiotic-associated ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5
... Colo., Oct. 9 Replidyne, Inc.,(Nasdaq: RDYN ) ... and,webcast on Tuesday, October 30, 2007 at 4:45 P.M. ... in the conference call by,dialing 800-435-1261 (domestic) or 617-614-4076 ... the conference call will be available approximately one,hour after ...
... of Clinical Programs, PALO ALTO, Calif., Oct. ... a late-stage biotechnology company that,develops central nervous system ... be a presenting company at the 4th,Annual BIO ... at the,Palace Hotel of San Francisco. The company,s ...
... Oct. 8 Inverness Medical,Innovations (Amex: IMA ) ... Agreement with Panbio Ltd, an Australian company traded on,the ... will acquire all of the issued shares in Panbio ... values the issued share capital of,Panbio at approximately AUD ...
Cached Biology Technology:Replidyne to Announce Third Quarter 2007 Earnings 2Avicena to Present at 4th Annual BIO InvestorForum Conference 2Inverness Medical Innovations Agrees to Acquire Panbio Ltd. 2
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
DTT, 25g...
...
Biology Products: