Navigation Links
Flu focus: NIH project aims for better drugs
Date:10/20/2009

stack. A protein complex called the polymerase, which is attached at the end of RNA, helps kick off replication once the assembly is injected into a healthy cell.

Tao said her team will use several techniques, including X-ray crystallography and electron cryomicroscopy, to obtain the first three-dimensional structure of the RNA-wrapped NP complex, a structure known as the ribonucleoprotein complex. The group will also purify individual segments of RNA, NP and polymerase; using some painstaking trial-and-error tests, they also will try to decipher the order and arrangements that must be brought together to create a viable ribonucleoprotein.

Krug's group will help determine the function of the various NP structures in replicating the viral RNA segments in cells, as well as how amino acid changes in the NP structure affect the ability of NP to function with the polymerase.

"We want to understand the assembly process," Tao said. "How do all those molecules come together? Obviously it cannot happen all at once. It must take place in a sequential manner, but that process is very poorly understood at the moment."

Krug said the funding for the project -- which comes from the American Recovery and Reinvestment Act -- arrives at a fortuitous time. "The flu is front and center in people's minds right now because of H1N1, and thanks to this grant, we're able to pursue an important new line of research that could answer fundamental questions about the disease."


'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert

Page: 1 2

Related biology news :

1. LaserCard Corporation Announces Expansion of Middle East Project
2. UD leads $5.3-million research project on rice epigenetics
3. RSC Project Prospect scoops prestigious award
4. UD leads $5.3-million research project on rice epigenetics
5. USC biomedical team to participate in $6 million low vision project
6. Green alga genome project catalogs carbon capture machinery
7. USDA Cooperative Agreement funds mosquito project at Rutgers
8. Life-saving clean water project secures $13M from Bill & Melinda Gates Foundation
9. UW launches cutting-edge DNA fin-printing project for salmon
10. BIO-key(R) PocketCop(R) Project Leading the Nation According to Televised Report
11. Are current projections of climate change-impacts on biodiversity misleading?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
(Date:11/15/2014)... -- While we may still be a few years away from ... to gain instant access to all that ailed his patients, ... tablets for monitoring and measuring our health are cropping up ... a tad Orwellian to some, but a new survey suggests ... opportunities into their healthcare regime. These are some ...
(Date:11/11/2014)...  Forensicon, Inc., a Chicago -based ... the promotion of Yaniv Schiff from Senior ... Schiff,s new role as Director, he will lead company ... examiners and provide leadership within the company,s digital forensics ... Schiff joined Forensicon in 2006 ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... a mathematical model of the mechanism birds use to ... feather structures involve the coordination of at least two ... "Understanding these mechanisms of feather growth gives a whole ... Richard Prum, senior author on the study. Prum is ...
... Conservation Union reported an unprecedented decline in biodiversity, with ... most species is loss of habitat. And as habitat ... accurately predict the population dynamics and extinction risk of ... new study, John Drake tests models traditionally used to ...
... cause of hospital-acquired infections can persist for days ... healthcare settings, including bed linens, computer keyboard covers ... at the 105th General Meeting of the American ... is a major cause of hospital-acquired infections in ...
Cached Biology News:Simple explanation for complex pattern of feather development 2Traditional models underestimate extinction rates 2
(Date:12/19/2014)... December 18, 2014 LayerBio is an ... and wound care. The National Eye Institute (NEI) at ... a Phase I SBIR grant to develop a drug-eluting ... the most common cause of vision loss in people ... worldwide. According to Dr. Ken Mandell, LayerBio’s Founder and ...
(Date:12/19/2014)... In contrast to traditional LED lights where ... Valoya uses proprietary LED technology to incorporate their spectra ... which is critical in low proximity installations. The Valoya ... its lifetime which is up to four times longer ... investment cost was clearly higher when compared to traditional ...
(Date:12/19/2014)... MILLBROOK, N.Y. , Dec. 18, 2014 Egenix, ... has been elected Chairman of the Board, to succeed ... President and CEO, but will continue as a member of ... that he has added to the company over almost twenty ... The Board of Directors has established a Search ...
(Date:12/17/2014)... Based on the revenues gained ... market is dominated by four major players contributing ... These players include GE Healthcare (U.K.), Siemens AG ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... be attributed to its strong product portfolio, which ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... for Removal of Clinical Hold, BERKELEY HEIGHTS, ... GNTA) announced that the Company has,received notice of ... Office for its pipeline product, tesetaxel, a leading ... for the tesetaxel drug,substance and to processes for ...
... Targets, COPENHAGEN, June 10 Nuevolution A/S ... (Nasdaq: LXRX ) aimed,at the discovery of ... targets., Under the terms of the alliance, ... to identify novel small molecule,lead compounds against a ...
... June 9 Boston Scientific,Corporation (NYSE: BSX ... it has revised its Rating Outlook on the ... Company,s long-term credit rating of,BB+., Fitch said ... Boston,Scientific is making toward stabilizing its drug-eluting stent ...
Cached Biology Technology:Genta Receives Notice of Allowances for European Patents Related to Composition and Processes for Tesetaxel, a Leading Oral Taxane 2Genta Receives Notice of Allowances for European Patents Related to Composition and Processes for Tesetaxel, a Leading Oral Taxane 3Genta Receives Notice of Allowances for European Patents Related to Composition and Processes for Tesetaxel, a Leading Oral Taxane 4Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals 2Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals 3Boston Scientific Welcomes Revised Outlook From Fitch Ratings 2Boston Scientific Welcomes Revised Outlook From Fitch Ratings 3
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... Note: Assays in Tris buffer, pH 10.2 ... glycine buffer system. Assays in diethanolamine buffer, ... of the glycine buffer system. Protein determined ... Tris-citrate buffer salts Preparation Unit Definition: One ...
... a wide variety of solvent vapors that can contaminate ... (GCF400) allows for the collection of liquid into a ... minimizes waiting period., Ultra low -104 o ... , Digital Display of temperature ...
... Trap is specifically designed for efficient ... as DMSO and DMF in the ... refrigeration system set at -5 o ... DMSO, while completely eliminating the risk ...
Biology Products: