Navigation Links
Flow of potassium into cells implicated in schizophrenia
Date:5/6/2009

A study on schizophrenia has implicated machinery that maintains the flow of potassium in cells and revealed a potential molecular target for new treatments. Expression of a previously unknown form of a key such potassium channel was found to be 2.5 fold higher than normal in the brain memory hub of people with the chronic mental illness and linked to a hotspot of genetic variation.

An extensive series of experiments suggest that selectively inhibiting this suspect form could help correct disorganized brain activity in schizophrenia without risk of cardiac side effects associated with some existing antipsychotic medications. Scientists at the National Institutes of Health and European colleagues report on threads of converging evidence in the May, 2009 issue of the journal Nature Medicine.

"The end game in linking genes with complex disorders like schizophrenia requires that we not only demonstrate statistical association, but also show how a gene version acts biologically to confer risk," explained Daniel Weinberger, M.D., director of National Institute of Mental Health's (NIMH) Genes Cognition and Psychosis Program, who led the research. "We found schizophrenia-like effects in brain circuitry and mental processing in perfectly healthy people who carry the risk-associated version of this potassium channel gene, even though they don't show any psychotic behavior."

Evidence suggests that schizophrenia stems from complex interactions between multiple genes and environmental factors. Several candidate genes have recently been statistically linked to the illness in large genome-wide association studies.

"Our study goes further, spanning discovery of a new gene variant, confirmation of its association with the illness, and multi-level probes into how it works in human post mortem brain tissue, the living human brain, and neurons," added Weinberger.

By regulating the flow of potassium ions into the cell,
'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Site used by sodium to control sensitivity of certain potassium ion channels
2. ESF EURYI award winner aims to stop cancer cells reading their own DNA
3. Newly created cancer stem cells could aid breast cancer research
4. AIDS interferes with stem cells in the brain
5. Clemson scientists shed light on molecules in living cells
6. Social habits of cells may hold key to fighting diseases
7. UF scientists reveal how dietary restriction cleans cells
8. Human derived stem cells can repair rat hearts damaged by heart attack
9. Scientists identify embryonic stem cells by appearance alone
10. Cells united against cancer
11. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Flow of potassium into cells implicated in schizophrenia
(Date:10/25/2014)... Research and Markets  has announced the ... report to their offering. Biometrics ... the basis of their physical or behavioral patterns. It ... such as fingerprints, face recognition, DNA, palm print, hand ... keystroke patterns and speech pattern/voice recognition. ...
(Date:10/22/2014)... -- Leading identity analyst firm Acuity Market Intelligence forecasts that ... will have a chip-based National eID card, including near-complete ... Asia , with its vast population, is ... 60% of all National eID cards issued between 2014 ... National eID Industry Report: 2014 Edition" — ...
(Date:10/18/2014)... October 2014 Psychological stress and stress-related psychiatric disorders ... diseases, but the molecular mechanisms underlying this ... contribute to the development of targeted preventive ... these devastating diseases. This work is presented ... in Berlin., Now an international group of ...
Breaking Biology News(10 mins):Biometrics Market in Europe 2014-2018: Key Vendors are 3M Cogent, Cognitec, NEC and Safran 2Biometrics Market in Europe 2014-2018: Key Vendors are 3M Cogent, Cognitec, NEC and Safran 3Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Researchers find why depression and aging linked to increased disease risk 2
... Although increasing evidence indicates that low-frequency repetitive ... for neural regulation, has antiepileptic effects, the ... team from the Affiliated Hospital of North ... of low-frequency repetitive transcranial magnetic simulation on ...
... head injuries or persistent seizures into a medically induced ... professional constantly monitor the patient,s brain activity and manually ... anesthesia. Now a computer-controlled system developed by Massachusetts ... making it more precise and efficient and opening the ...
... world become even drier, water will not be the only resource ... be affected, and their imbalance could affect the lives of one-fifth ... in Arizona, who may be in for a dustier future. ... Nature that details how soil changes may occur and discusses ...
Cached Biology News:Automated system promises precise control of medically induced coma 2Automated system promises precise control of medically induced coma 3Plant production could decline as climate change affects soil nutrients 2
(Date:10/22/2014)... Columbia, Md. (PRWEB) October 21, 2014 ... package, an LC/MS/MS data tool for the pain management ... efficiency of data processing and review by allowing users ... importance to clinicians. , QuantAnalytics allows analysts to ... orders. This expedites data processing by eliminating the need ...
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... According to new market research report "Cloud ... Deployment & Support), by Service Model (SaaS, PaaS, ... (Hybrid & Community)) - Global Forecast to 2019", ... Professional Services Market into various sub-segments with an ... identifies the drivers and restraints for this market ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... Diabetes Federation, approximately 400 million people worldwide are living ... 552 million people by 2030.  The global market for ... In 2012 approximately 330,000 people worldwide died from pancreatic ... of death due to cancer in the ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
... Researchers at the Wyss Institute for Biologically Inspired Engineering ... a method for inducing magnetic sensitivity in an organism ... potentially be used to magnetize a variety of different ... research findings appear in today,s issue of PLoS ...
... LONDON, Feb. 28, 2012  Thomson Reuters announced the ... new capability that speeds access to critical life sciences ... life sciences platform, Thomson Reuters Cortellis. ... uses sophisticated application programming interfaces (APIs) to enhance ...
... Feb. 28, 2012 ViroPharma Incorporated (Nasdaq: VPHM ... and year ended December 31, 2011. In 2011, ... net product sales, including $251 million in net sales of ... sales of Vancocin® (Vancomycin Hydrochloride Capsules, USP); Attained non-GAAP ...
Cached Biology Technology:New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities 2New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities 3Thomson Reuters Cortellis Drives Drug Discovery and Development With Powerful New Web Services 2ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 2ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 3ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 4ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 5ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 6ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 7ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 8ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 9ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 10ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 11ViroPharma Incorporated Reports Fourth Quarter and Full Year 2011 Financial Results 12
... a concentrated formulation of a rinsing buffer ... technology, as well as for manual immunostaining. ... Brigati M.D., Department of Pathology, University of ... recommended for all the rinsing steps performed ...
... MALDI O-TOF creates a new category for ... platform that has been licensed to the ... Manitoba. , As the first single MALDI-TOF ... collisional cooling, the prOTOF 2000 represents a ...
... miVac DNA is an ideal small concentrator ... concentrator capable of removing water and organic ... including tubes, microplates, vials and round bottom ... for the busy lab. ,The built-in special ...
... The H2OBIT™ is a fully licensed, high throughput, ... processing of up to 24 microplates. This equates ... plates. A robotic arm rapidly transfers ... resulting in temperature ramping times that are considerably ...
Biology Products: