Navigation Links
Florida State researcher uncovers protein's role in cell division
Date:6/15/2010

DK5RAP2 was at least partly responsible. His team tested the protein's role using a mutant mouse in which the protein was "knocked out" and not functioning. These researchers looked for any effects on engagement and "cohesion," in which centriole pairs are tethered by fibers.

They noted in the mutant mouse that engagement and cohesion did not occur in their typical orderly fashion and that centrioles were more numerous and often single rather than paired. The amplified centrioles assembled multipolar spindles, a potential hazard for chromosomal stability. The researchers concluded that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication.

They are looking at how this discovery might apply to the human brain.

"The two mouse mutants we made mimic the two known mutations in humans in CDK5RAP2 which has another name, MCPH3, in humans," Megraw said. "The disease associated with that is a small brain.

"Our next step is to look at the brains of the mice and try to determine what's wrong. We think it's the stem cells that the progenitors that give rise to all the neurons in the brain are dying early or changing from a progenitor into a neuron too early."

Another gene called myomegalin might be functionally redundant to CDK5RAP2, Megraw said, adding, "Our goal is to knock that out, too."

The research his lab has done might also be applicable to cancer drugs for humans, he said. Centrosomes organize microtubules, which are structures in the cell that many important anti-cancer drugs target.

"The amplified centrioles and multipolar spindles suggest that the mutant mice may be more susceptible to developing cancers," Megraw said. "We are in a position to test this with our new mouse models."


'/>"/>

Contact: Timothy Megraw
timothy.megraw@med.fsu.edu
850-945-9271
Florida State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida
2. Plastic Surgeons Rate Auction of World-Class Florida Laterra Spa May 21 a Perfect 10, Great Business Opp for Celebrity Retreat
3. Bionanotechnology has new face, world-class future at Florida State
4. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
5. University of Florida study provides insight into evolution of first flowers
6. New York, Florida schools win awards at national student competition
7. Little Salt Spring underwater archeological site in Florida receives new funding
8. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
9. Holy guacamole: invasive beetle threatens Floridas avocados
10. Florida professor creates endowment for insect scientists
11. Acoustical Meeting, Nov. 10-14, 2008 in Miami, Florida
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Florida State researcher uncovers protein's role in cell division
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a ... it is seeing a staggering demand from its licensees ... the Company revealed, is not solely coming from fitness ... as well. "A wearable is only as ... result, accuracy is the ultimate driver in long-term mass ...
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... time to economically value the greenhouse gas-trapping potential of mine ... and geologist Michael Hitch of the University of British Columbia ... for its CO 2 -sequestration potential, or "SP." He says ... offset CO 2 emissions with so-named "SP rock," and ...
... The human nose has millions of olfactory neurons grouped into ... expresses only one odorant receptor, and all neurons expressing the ... an organization that allows for specific odors to be sensed. ... neurons that express a specific odor receptor that detects a ...
... that exposes approximately half of the world,s population to the ... disease. In a study published in the latest issue of ... and his team at Instituto Gulbenkian de ... forms of malaria can be prevented by a simple mechanism ...
Cached Biology News:Researchers tap into CO2 storage potential of mine waste 2Researchers tap into CO2 storage potential of mine waste 3How cells in the nose detect odors 2How cells in the nose detect odors 3Tolerance to malaria by means of iron control 2
(Date:12/24/2014)... 2014 Earlier this year in a ... director of the Adult Stem Cell Technology Center, LLC ... and under appreciated unique property of adult tissue stem ... Cells: Misunderstood in the Past, Important for the Future,” ... He gave the address at the 4th World ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ... The only negative is the housing market remaining soft. ...
(Date:12/24/2014)... The report expects global cell isolation and ... also provides a carefully analyzed data about the vital ... market. , Full Copy of Report @ http://bit.ly/1yUxy0T ... for cell expansion will keep witnessing growth at an ... to be driven by rapid technological advancements, government funding ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... the first self-powered nano-device that can transmit data wirelessly ... Nano Letters , they say it proves the ... sensors, airborne and stationary surveillance cameras and sensors, wearable ... batteries on energy collected from the environment. ...
... 2011 Solid grounding in science is widely considered ... leaders. From biochemists and pharmacists to physician assistants and ... market lies in the fields of healthcare and science. ... conducted by Harris Interactive for University of the ...
... Synthetic Genomics, Inc. (SGI), a privately held company applying ... including clean renewable energy, new food sources, and medicines, ... as Chief Financial Officer (CFO), effective June 18, 2011. ... financial aspect of the company. He will report directly ...
Cached Biology Technology:Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 2Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 3Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 4Synthetic Genomics Inc. Appoints Joseph Mahler as Chief Financial Officer 2
... Analysis Note: The kit contains all ... convenient determination of NADPH-cytochrome c reductase activity ... purified microsomes [endoplastic reticulum (ER)]. It has ... tissues such as liver, kidney, brain, spleen, ...
... CHEMICON's Cell Transformation Detection Assay is an ... is considered the most stringent assay for ... this assay, cells (pre-treated with carcinogens or ... in soft agar medium for 21-28 days. ...
... The EZ DNA Methylation Kit uses a ... for DNA methylation analysis. The kit is ... takes place between cytosine and sodium bisulfite ... EZ DNA Methylation Kits innovative in-column desulphonation ...
... Select Tissue Arrays are intended for laboratory ... were fixed in neutral buffered formalin and ... diagnosis was performed by certified pathologists. ... blocks and relocated into a new recipient ...
Biology Products: