Navigation Links
Flipping the 'off' switch on cell growth
Date:2/22/2013

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying known as DNA replication and new cell growth to many of the body's functions and in such diseases as cancer.

"We've long known that this protein, HIF-1α, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1α is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of Science Signaling.

With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1α in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.

To learn how HIF-1α's own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1α. They found two, MCM3 and MCM7, that limited HIF-1α's activity, and were also part of the DNA replication machinery. Those results were reported in 2011.

In the new research, Semenza and his colleagues further probed HIF-1α's relationship to DNA replication by comparing cells in low
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Noncoding RNAs offer huge therapeutic and diagnostic potential
2. Get off my lawn: Song sparrows escalate territorial threats - with video
3. Modern growing methods may be culprit of coffee rust fungal outbreak
4. International biodiversity data symposium to mark the kickoff of the EU BON project
5. Tree die-off triggered by hotter temperatures
6. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
7. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
8. Study of human specimen collections in the US offers first look at their huge diversity
9. Dartmouth research offers new control strategies for bipolar bark beetles
10. Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
11. Study offers new insights into the mechanics of muscle fatigue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... take stress in stride; others are done in by ... molecular mechanisms of this so-called stress gap in mice ... could lead researchers to better understand the development of ... people, each animal has unique experiences as it goes ... experiences can alter the expression of genes, and as ...
(Date:9/1/2014)... the U.S. has improved steadily in recent yearsspurred in ... quality remains poor and disparities continue to widen among ... from Harvard School of Public Health (HSPH). , "The ... the extensive efforts by many groups and individuals to ... it also indicates that these efforts need to be ...
(Date:9/1/2014)... Conventional wisdom has long held that corals ... reefs are passive organisms that rely entirely ... as nutrients and oxygen. But now scientists at ... in Israel have found that they are far ... into turbulent patterns that greatly enhance their ability ...
Breaking Biology News(10 mins):Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3Nature's tiny engineers 2Nature's tiny engineers 3
... to thwart persistent bacterial infections and better control ... artificial chemicals that infiltrate and sabotage bacterial "mobs." ... at the 229th national meeting of the American ... Blackwell described the ongoing construction of a new ...
... where you might find love these days. A team ... psychologist found love-related neurophysiological systems inside a magnetic resonance ... brains of 17 young men and women who each ... , The multidisciplinary team found that early, intense romantic ...
... Research Center have, for the first time, induced a ... the first demonstration of "hibernation on demand" in a ... cancer and prevent injury and death from insufficient blood ... essence, temporarily converting mice from warm-blooded to cold-blooded creatures, ...
Cached Biology News:To control germs, scientists deploy tiny agents provocateurs 2Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 2Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 3Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 4Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 5Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 6Buying Time Through Hibernation on Demand 2Buying Time Through Hibernation on Demand 3Buying Time Through Hibernation on Demand 4Buying Time Through Hibernation on Demand 5
(Date:9/2/2014)... -- Technology Applications International Corporation (the "Company" or "NUUU")(OTC BB: ... Inc. has signed an additional exclusive licensing agreement with ... Johnson Space Center in Houston , ... Charles J. Scimeca , NUUU,s ... latest, exclusive agreement with NASA. In addition to our ...
(Date:9/2/2014)... 2, 2014  Xencor, Inc. (NASDAQ: ... monoclonal antibodies for the treatment of autoimmune diseases, ... the appointment of Debra Zack , M.D., ... of Lloyd Rowland , senior vice president, ... "Debra,s expertise in biologics clinical development and ...
(Date:9/2/2014)... 02, 2014 PMG Research, Inc ... clinical research site: PMG Research of Rocky Mount. Effective ... of the clinical research department at Boice-Willis Clinic ... in eastern North Carolina. This new site enhances PMG’s ... in Rocky Mount and the surrounding communities, this brings ...
(Date:9/1/2014)... Sept. 1, 2014 Reportlinker.com announces that ... its catalogue: India Solid Waste Management ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In ... main governing bodies responsible for complete handling and ... an average, around 135,000 MT solid waste is ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8
... , NEW YORK, Aug. 13 Cadus Corporation (OTC ... 30, 2009. , , Revenues were $0 for the second ... for the second quarter of 2009 was $103,330, compared to net income of ... for the second quarter of 2009 was $0.01, compared to basic net income ...
... , , , , ... ABT ) today announced the expansion of the company,s XIENCE ... of the company,s market-leading XIENCE V(R) Everolimus Eluting Coronary Stent System ... allows for more than 2,000 patients from the XIENCE V USA ...
... 13 /PRNewswire-FirstCall/ - Spectral Diagnostics Inc., (TSX: SDI), a ... a therapeutic targeting severe sepsis, today announced its financial ... , "During the quarter, results of the EUPHAS trial ... Medical Association (JAMA). The findings showed that the Toraymyxin(TM) ...
Cached Biology Technology:Cadus Reports Second Quarter 2009 Results 2Cadus Reports Second Quarter 2009 Results 3Cadus Reports Second Quarter 2009 Results 4Cadus Reports Second Quarter 2009 Results 5Abbott Expands XIENCE V(R) USA Trial to Enroll Patients into Landmark Dual Anti-Platelet Therapy (DAPT) Trial 2Abbott Expands XIENCE V(R) USA Trial to Enroll Patients into Landmark Dual Anti-Platelet Therapy (DAPT) Trial 3Abbott Expands XIENCE V(R) USA Trial to Enroll Patients into Landmark Dual Anti-Platelet Therapy (DAPT) Trial 4Spectral announces second quarter 2009 results 2Spectral announces second quarter 2009 results 3Spectral announces second quarter 2009 results 4Spectral announces second quarter 2009 results 5Spectral announces second quarter 2009 results 6Spectral announces second quarter 2009 results 7Spectral announces second quarter 2009 results 8