Navigation Links
Flipping a switch on neuron activity
Date:3/7/2011

WASHINGTON, D.C. (March 7, 2011) -- All our daily activities, from driving to work to solving a crossword puzzle, depend on signals carried along the body's vast network of neurons. Propagation of these signals is, in turn, dependent on myriad small molecules within nerve cells -- receptors, ion channels, and transmitters -- turning on and off in complex cascades. Until recently, the study of these molecules in real time has not been possible, but researchers at the University of California at Berkeley and the University of Munich have attached light-sensing modules to neuronal molecules, resulting in molecules that can be turned on and off with simple flashes of light.

"We get millisecond accuracy," says Joshua Levitz, a graduate student at Berkeley and first author of the study. According to Levitz, the "biggest advantage is that we can probe specific receptors in living organisms." Previous methods using pharmacological agents were much less specific, affecting every receptor in every cell. Now, investigators can select individual cells for activation by focusing light. And by attaching light-sensing modules to one class of molecules at a time, they can parse the contributions of individual classes to neuronal behavior.

Levitz will be presenting a system in which G-protein-coupled receptors, molecules that play key roles in transmitting signals within cells, can be selectively activated. He is planning to use the system to study the hippocampus, a region of the brain where memories are formed, stored and maintained. There may be clinical utility to the system as well, he points out. G-protein-coupled receptors are also critical for vision in the retina, and light-sensing versions could potentially be introduced into people with damaged retinas in order to restore sight.


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists discover genetic switch that increases muscle blood supply
2. MIT-- parts of brain can switch functions
3. New lignin lite switchgrass boosts biofuel yield by more than one-third
4. Scripps Research study sheds light on RNA on/off switches
5. Scientists find the master switch for key immune cells in inflammatory diseases
6. Scripps Research scientist uncovers switch controlling protein production
7. When their tools get dull, leaf-cutters switch jobs
8. Scientists discover molecular switch that contributes to cellular aging process
9. University of Illinois researchers discover potential new virus in switchgrass
10. Researchers could use plants light switch to control cells
11. NC State develops more precise genetic off switches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... eye wash is a basic first aid supply for any work environment, but most personal ... rinse first if a dangerous substance enters both eyes? It’s one less decision, and likely ... dual eye piece. , “Whether its dirt and debris, or an acid or alkali, getting ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions to ... symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory science, ...
Breaking Biology Technology: