Navigation Links
'Flightless' molecule may prevent cancer from spreading from 1 tissue to another
Date:7/31/2012

Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. In a new report published in the August 2012 print issue of The FASEB Journal (http://www.fasebj.org), laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

"The study of flightless and its role in the control of cell movement offers the promise of developing new drugs and treatments to control diseases in which cell movement has gotten out of control," said Christopher A. McCulloch, from Matrix Dynamics Group at the University of Toronto in Canada. "We hope that one day treatments to regulate cell movement could be used to bring under better control the spread of cancer cells from a tumor into the rest of the body."

To make this discovery, scientists used three groups of cells that made either normal amounts of flightless, or were genetically modified to produce no flightless, or to make above-normal amounts of flightless. Researchers then studied the rate of movement of these different groups of cells and examined the specialized parts of cells that enable them to stick to tissues. When the stickiness of the cells to underlying tissues was examined, results showed that flightless had a marked effect on how quickly cells could detach from underlying tissues and move forward in response to stimuli that encourage them to migrate.

"Fighting a single tumor in one organ is hard, but the fact that many cancers metastasize adds new obstacles to treatment," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report on 'flightless' is an important first step toward to preventing cancers from taking off to other parts of the body."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Small molecule may play big role in Alzheimers disease
2. Researchers discover molecule in immune system that could help treat dangerous skin cancer
3. Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
4. Nature: Molecule changes magnetism and conductance
5. Master molecule may improve stem cell treatment of heart attacks
6. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
7. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
8. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
9. FirstMark Scientific Board of Advisors Meet to Discuss New Clinical Studies for PREvent
10. LSUHSC research finds treating stress prevented new MS brain lesions
11. Can you hear me now? New strategy discovered to prevent hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Dr. Asher Kimchi, Founder and Chairman of ... 2017 IAC Awards at the 22nd World Congress on Heart Disease held in Vancouver, ... to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. ...
(Date:7/20/2017)... and PLYMOUTH, Minn., July 20, 2017   ... a personalized genetic evaluations company, today announced that ... partnership investigating a genetic mutation implicated in KCNQ2 ... the partnership for a second case involving an ... the KCNQ2 Cure Alliance and Pairnomix entered into ...
(Date:7/18/2017)... (PRWEB) , ... July 18, 2017 , ... Sourcing custom ... with your needs and has the capabilities to properly execute your job can take ... customglassparts.com is a sourcing portal designed to showcase the company’s capabilities and ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... Framework, and has released the first phase of the Allotrope Framework for commercial ... Practices Awards were created to “not only elevate the critical role of information ...
Breaking Biology Technology: