Navigation Links
Flies reveal kidney stones in-the-making
Date:4/6/2013

ny human kidney stones. The growths lodge in the fly's Malpighian tubule, which is the equivalent of the convoluted tubules in the million or so microscopic nephrons that make up a human kidney.

Kidney stone formation is an example of "ectopic calcification," in which calcium hydroxyapatite, a normal constituent of bones and teeth, forms elsewhere. Understanding how kidney stones form may also shed light on other sites of ectopic calcification, such as the coronary arteries.

In many animal models of kidney stones, researchers feed toxins such as antifreeze ethylene glycol to induce the condition. Obviously, this is not how the human condition begins. However, fruit flies with a mutation in the gene that encodes the enzyme xanthine dehydrogenase develop kidney stones that are remarkably like their human counterparts, rich in calcium hydroxyapatite.

Dr. Chi and his colleagues used the fly model to look for genes which, when silenced, prevent or ameliorate kidney stones. The researchers scrutinized over 80 genes, based on known functions, and narrowed them down to fewer than 10 that are involved with formation of kidney stones. Genes related to zinc transport in particular seemed to play a major role, demonstrating the importance of the element in stone formation.

The researchers developed a visually striking method to watch fly kidney stones form. They labeled calcium hydroxyapatite with fluorescent bisphosphonate, an osteoporosis drug. The technique reveals tiny green glowing balls that are the seeds of kidney stones.

Dr. Chi calls the beginnings of the stones "calcified nanoparticles" and puts their size into perspective. "If you had a rope from Hong Kong to San Francisco, to find a calcified nanoparticle, you'd be looking for a 5 to 10 foot segment on that rope." The nanoparticles in the fly may be an early equivalent of precursor lesions in people called Randall plaques, he added.

Zinc transport is im
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mathematical butterflies provide insight into how insects fly
2. Blind flies without recycling
3. UF study shows spiders, not birds, may drive evolution of some butterflies
4. Fruit flies force their young to drink alcohol -- for their own good
5. Pirate-like flies connect symbiosis to diversity
6. Scientists mimic fireflies to make brighter LEDs
7. Treating stable flies in pastures
8. Stopping flies before they mature
9. Protecting US troops against sand flies
10. Viable and fertile fruit flies in the absence of histone H3.3
11. Evolutionary straitjacket means flies cant take the heat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... to stop the spread of drug resistance in typhoid fever, ... published in the journal eLife . The ... bacteria can out-compete drug sensitive strains when grown in the ... is transmitted by consuming food or drink that is contaminated ...
... 9, 2013 /PRNewswire-iReach/ -- With the holiday season comes the ... American will put on up to five pounds in just ... CDC (Center for Disease Control) more than 65% of Americans ... obese. (Photo: http://photos.prnewswire.com/prnh/20131209/MN29878 ) ...
... inhibitors (SSRIs) are the most commonly prescribed antidepressants, but ... often try several different SSRI medications, each with a ... is effective. It takes three to four weeks to ... and their families continue to suffer. Now researchers ...
Cached Biology News:Antibiotic-resistant typhoid likely to spread despite drug control program 2HCG Injections and B12 shots now in stock at US Vitamin Injections Site 2A personal antidepressant for every genome 2A personal antidepressant for every genome 3
(Date:10/19/2014)... Mass. , Oct. 19, 2014 NextCODE Health, ... the whole genome in real time, today announced the launch ... NextCODE Exchange , at the American Society of Human ... . To learn more, sign up and apply for free ... its unique features and benefits can be viewed here ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla Market ... (2011 - 2016)," analyzes the chocolate market by ... market drivers, restraints, and opportunities for the chocolate market ... chocolate market is expected to grow from $83.2 billion ... CAGR of 2.7% from 2011 to 2016. , Get ...
(Date:10/19/2014)... 19, 2014 The report "Unmanned ... Homeland Security), Technology, Payload, Type & by Geography ... the global unmanned ground vehicle market into various ... of market sizes. The report also identifies the ... impacting it along with the adoption trends. , ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... March 7, 2011 Reportlinker.com announces that a ... catalogue: Biomarkers - Technologies,markets and ... SummaryThis report follows the broad definition ... be objectively measured and evaluated as an indicator ...
... 7, 2011 Gene Codes Corporation has pulled back ... release of Sequencher® with support for Next Generation Sequencing ... of Biomolecular Resource Facilities [ABRF] in San Antonio, Gene ... SOLiD, Illumina and 454 instruments. Conference attendees were given ...
... measurement in the world of nanoparticles has now become a ... The UCSB research team has developed a new instrument ... a few tens of nanometers. The study will be published ... appear in the April print issue of the journal. ...
Cached Biology Technology:Reportlinker Adds Biomarkers - Technologies, Markets and Companies 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 3New instrument keeps an 'eye' on nanoparticles 2
Cell Culture Flask, nontreated polystyrene...
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
...
... This high pressure gradient system ... piston pumps and the Adept CE 4200 dual ... and data processing is provided by PowerStream data ... heater/chillers can be supplied. The supplied ...
Biology Products: