Navigation Links
Flies can turn off their immune response
Date:9/3/2007

The immune response is actively turned on to target and destroy foreign infectious elements, but in the interests of self-preservation, it is just as important to turn the immune system off to avoid damage to oneself by friendly fire. The fruit fly Drosophila has served as a good model for the induction of an innate immune response, pointing to conserved pathways and mechanisms. Recent work shows that the flys immune response is more subtly regulated and produces a wider range of responses than was thought possible even just a few years ago. In a study to be published this week in the premier open-access journal PLoS Biology, Young-Joon Kim and colleagues from Seoul, Korea show that the fly immune response is edited and repressed.

The authors report a mechanism of control that relies on the transcription factors AP-1 and STAT to prevent the excessive activation of the NF-Bmediated immune response. Thus, AP-1 and STAT, renowned for their role in activating the NF- Bmediated immune response, appear also to participate in its attenuation. In their role as negative regulators, AP-1 and STAT form a complex HMG protein and HDAC, proteins known to be involved in DNA bending and chromatin structure. This complex is then recruited to the promoter regions of NF-B target genes, causing the chromatin structure near the NF- B target genes to contract and the expression of NF-B target genes to shut down. Kim and colleagues found that mis-regulation of this negative-feedback process increased the lethality of bacterial infection in Drosophila. In mammals, over-activated NF-Bmediated immune responses can manifest in a utoimmune disease. Thus, feedback inhibition of NF- B appears to be evolutionarily conserved to maintain properly balanced immune responses.


'/>"/>
Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Master gene controls healing of skin in fruit flies and mammals
2. Remote control flies? Fly behavior controlled by laser light
3. UI researcher studies deafness in fruit flies, humans
4. How monarch butterflies are wired for navigation
5. Gap-climbing fruit flies reveal components of goal-driven behaviors
6. Expanding forests darken the outlook for butterflies, study shows
7. Hormones and growth: The control of body size and developmental growth rate in fruit flies
8. Huntingtons cure in flies lays groundwork for broader treatment approaches
9. Flies on speed offer insight into the roles of dopamine in sleep and arousal
10. Female butterflies go for sparkle -- not size -- when choosing to mate
11. Researchers find gland that tells fruit flies when to stop growing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... long known that people with Down syndrome have a ... childhood, they haven,t been able to explain why. ... uncovered a connection between the two conditions. , In ... Nature Genetics , the researchers track the genetic chain ... syndrome to the cellular havoc that occurs in ALL. ...
(Date:4/18/2014)... past 20 years, researchers have published soil organic carbon ... suggested that soil organic carbon can be sequestered by ... no-till systems. However, there is a growing body of ... soybean rotations without cover crops, small grains, and forages ... the published rates. , "Some studies have shown that ...
(Date:4/17/2014)... Mo. April 17 In the most densely forested ... forests reflect two centuries of human needs, values and ... and clearing forests for agriculture and development, have set ... a U.S. Forest Service study reports. , The report ... conditions and management needs in the Northern United States ...
Breaking Biology News(10 mins):Dana-Farber researchers uncover link between Down syndrome and leukemia 2Dana-Farber researchers uncover link between Down syndrome and leukemia 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3
... you consider biodiversity, but it turns out that even a ... compromise some key ecosystem functions and could lead to lower ... (15 January) in the SfAM journal, Environmental Microbiology , ... functions such as the removal of pesticide residues are not ...
... for you to eat fiber and not abuse antibiotics. ... of niacin to protect patients, cardiovascular systems also plays a ... a study featured on the cover of the journal ... diet reduces the risk of colon problems and indicates that ...
... vicinity of a molecule can change spatial arrangement of its ... was able to change persistently positions of the nuclei of ... copper atom to the molecule. A subatomic bit formed ... be switched by approaching a single copper atom to the ...
Cached Biology News:Loss of biodiversity limits toxin degradation 2Findings bolster fiber's role in colon health 2Findings bolster fiber's role in colon health 32-proton bit controlled by a single copper atom 22-proton bit controlled by a single copper atom 3
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and CDS ... January 23, 2014 at 2pm EST (11am PST), “Natural ... topic focuses on how technology can turn raw, heterogeneous ... for government agencies. The online webinar will last approximately ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... SHANGHAI, Sep. 4 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,(Nasdaq: ... Chinese firm,specializing in the manufacture, research, development, marketing ... Company,s,management team will attend the Susquehanna International Group ... The SIG 3rd Annual ...
... , AURORA, Ontario, Sept. 4 Helix BioPharma ... has accepted subscriptions for the purchase, by way of private placement, ... gross proceeds totaling CDN$13,581,250. The Company anticipates closing the private ... unit consists of one common share and one common share purchase ...
... Kendle (Nasdaq: KNDL ), a leading, global full-service ... the upcoming Robert Baird 2009 Health Care Conference on Sept. ... New York City. , , (Logo: ... Kendle,s formal presentation will be given by Senior Vice President ...
Cached Biology Technology:China-Biotics, Inc. to Attend the SIG 3rd Annual Beijing Management Summit 2Helix BioPharma Announces $13.5 Million Private Placement 2Kendle to Present at Robert Baird 2009 Health Care Conference 2
... Thermo has established an expertise in the ... for solid support synthesis and synthesis in ... by Mass Spectrometry and analytical HPLC at ... products that meet the highest quality standard. ...
... Thermo Labsystems' Wellwash AC ... twin-strip microplate washer available, and ... sensors for wash, waste and ... shaker and automatic rinsing and ...
The Wellwash 4 Mk 2 combines high performance and flexibility with reliability, simplicity and ease of use. This advanced microplate washer meets the exacting standards of today's assay requirements....
... is a genetically engineered endonuclease. This unique ... RNA while having no proteolytic activity. It ... conditions and possesses an exceptionally high specific ... from recombinant proteins, its use enables compliance ...
Biology Products: