Navigation Links
Flies can turn off their immune response
Date:9/3/2007

The immune response is actively turned on to target and destroy foreign infectious elements, but in the interests of self-preservation, it is just as important to turn the immune system off to avoid damage to oneself by friendly fire. The fruit fly Drosophila has served as a good model for the induction of an innate immune response, pointing to conserved pathways and mechanisms. Recent work shows that the flys immune response is more subtly regulated and produces a wider range of responses than was thought possible even just a few years ago. In a study to be published this week in the premier open-access journal PLoS Biology, Young-Joon Kim and colleagues from Seoul, Korea show that the fly immune response is edited and repressed.

The authors report a mechanism of control that relies on the transcription factors AP-1 and STAT to prevent the excessive activation of the NF-Bmediated immune response. Thus, AP-1 and STAT, renowned for their role in activating the NF- Bmediated immune response, appear also to participate in its attenuation. In their role as negative regulators, AP-1 and STAT form a complex HMG protein and HDAC, proteins known to be involved in DNA bending and chromatin structure. This complex is then recruited to the promoter regions of NF-B target genes, causing the chromatin structure near the NF- B target genes to contract and the expression of NF-B target genes to shut down. Kim and colleagues found that mis-regulation of this negative-feedback process increased the lethality of bacterial infection in Drosophila. In mammals, over-activated NF-Bmediated immune responses can manifest in a utoimmune disease. Thus, feedback inhibition of NF- B appears to be evolutionarily conserved to maintain properly balanced immune responses.


'/>"/>
Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Master gene controls healing of skin in fruit flies and mammals
2. Remote control flies? Fly behavior controlled by laser light
3. UI researcher studies deafness in fruit flies, humans
4. How monarch butterflies are wired for navigation
5. Gap-climbing fruit flies reveal components of goal-driven behaviors
6. Expanding forests darken the outlook for butterflies, study shows
7. Hormones and growth: The control of body size and developmental growth rate in fruit flies
8. Huntingtons cure in flies lays groundwork for broader treatment approaches
9. Flies on speed offer insight into the roles of dopamine in sleep and arousal
10. Female butterflies go for sparkle -- not size -- when choosing to mate
11. Researchers find gland that tells fruit flies when to stop growing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... , ... May 24, 2016 , ... ... diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute ... engines of wound healing and tissue regeneration. , The novel method, developed by ...
(Date:5/24/2016)... La Jolla, CA (PRWEB) , ... May 24, 2016 , ... ... and financial planning for corporate executives and entrepreneurs, held The Future of San Diego ... leaders in the San Diego life science community attended the event with speakers Dr. ...
(Date:5/23/2016)... ... ... blood donations in South Texas and across the nation is growing. , But according to ... are on the decline. In fact, donations across the country are at their lowest point ... the last four years alone. , There is no substitute for blood. , “We want ...
(Date:5/23/2016)... , May 23, 2016 Zimmer Biomet Holdings, ... healthcare, today announced that its Board of Directors has approved ... the second quarter of 2016. The cash ... about July 29, 2016 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
Breaking Biology Technology: