Navigation Links
'Fishy' clue helps establish how proteins evolve
Date:1/27/2009

n synthesis," said Yale postdoctoral fellow and lead co-author Patrick O'Donoghue. "This is the key difference that makes Pyl so interesting and valuable to molecular biologists. It opens the door to engineering the genetic code."

Pyl is so rare that it has been found in only seven organisms. Each of these microbes evolved in an unusual environmental niche and all use methylamines the compounds that make fish smell "fishy" as a source of energy. Sll's research team characterized and crystallized the molecules that "manage" Pyl and created images that show how these molecules have evolved to work together.

"This is the handle we needed to effectively produce an 'expanded' genetic code," said O'Donoghue. "Now we have the ability to directly genetically encode other uncommon amino acids. By doing that, we will be able to isolate the role of particular modifications and to begin to understand their functions and their role in human disease."

"We have found why it is probably not accidental that out of more than 300 amino acids found in natural proteins, only two have been added beyond the standard 20-member amino acid alphabet," said principal investigator Dieter Sll, Sterling Professor of Molecular Biophysics & Biochemistry and professor of chemistry at Yale.

"This work provides a tantalizing glimpse into how proteins have evolved in living cells," said Laurie Tompkins, who oversees protein synthesis grants at the National Institutes of Health's National Institute of General Medical Sciences, which partially supported the work. "The unique way in which the synthetase binds its tRNA substrate is a testament to the ancient roots of this remarkable enzyme."


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fishy future written in the genes
2. Natural chemical found in broccoli helps combat skin blistering disease
3. Device helps patients survive, regain function til transplant
4. Presence of gene mutation helps guide thyroid cancer treatment
5. CABI helps phase out dangerous pesticide in EU
6. Diet support helps chronic kidney patients
7. Argonne helps China create cleaner Beijing for 2008 Olympics
8. A tiny pinch from a z-ring helps bacteria cells divide
9. Ultraviolet light helps to secure water supply
10. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
11. Handbook helps parents deal with childhood infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fishy' clue helps establish how proteins evolve
(Date:7/10/2014)... -- Unisys Corporation,s (NYSE: UIS ) subsidiary in ... that it has been selected by the Dutch Custodial Institutions ... Provision Biometrics solution for penitentiaries across The Netherlands ... a solution based on its open standards-based LEIDA ... is up to seven years, with the new system expected ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... York , July 7, 2014 ... Transparency Market Research "Electronic Access Control Systems Market Global ... - 2019," the global Electronic Access Control systems market ... is expected to grow at a CAGR of 12.6% ... of USD 31,187.8 million in 2019. Browse ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... from the Walter and Eliza Hall Institute in Melbourne, ... Society, the UK,s peak academy promoting excellence in science. ... inducted to the Royal Society in 2011, including four ... review process on the basis of excellence in science. ...
... Polarstern of the Alfred Wegener Institute for Polar and ... at its homeport of Bremerhaven after a seven-month expedition ... in 15 countries took part in the expedition. The ... the water in the deep Weddell Sea continues further. ...
... David Cleveland, a professor of environmental studies at UC Santa ... a great example of what many are advocating as a ... a local food system. Santa Barbara County ranks in ... in value of agricultural products, with 80 percent of that ...
Cached Biology News:Top Australian malaria researcher elected Fellow of the Royal Society 2Top Australian malaria researcher elected Fellow of the Royal Society 3Research ship Polarstern returns from Antartica 2Research ship Polarstern returns from Antartica 3UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 2UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 3
(Date:7/10/2014)... fight against terrorism with the creation of a sensor ... use of light and special glass fibres. , Published ... , the researchers describe a novel optical fibre sensor ... 6.3 ppm (parts per million). It requires an analysis ... detection has involved looking for metals that encase them ...
(Date:7/10/2014)... today in the journal PNAS (Proceedings of the ... of day and sleep deprivation have a significant effect ... looking at the best time of day to test ... for administering medicines effectively. , Researchers from the University ... investigated the links between sleep deprivation, body clock disruption ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
(Date:7/10/2014)... geckos and spiders can sit upside down forever. Nanophysics makes ... this in an article just published in Physical Review ... , Geckos and spiders that seem to be able to ... researchers worldwide for many years. We will soon be able ... as the gecko,s foot. But the fact is, sooner or ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2
... Batey, Ph.D.2 , and Brendan Bohannan, Ph.D.1 , ... , , ... , Abstract , ... to measure the ammonia-oxidizing bacteria (AOB) population in soils maintained under 16 environmental regimes.,DNA was ...
... , AquaPure Genomic DNA Isolation ... range: 100300 g DNA, , Method ... 1. Use fresh blood within 10 sec of venipuncture to avoid clotting. Alternatively, , ... reduce , DNA degradation. Blood may be either fresh or frozen. ...
... , , , ... gel support frame, used with the Trans-Blot , ... from agarose gels to nylon membrane in minutes, without any gel pretreatments. , ... generates a , high field strength (V/cm 2 ...
Cached Biology Technology:Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 2Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 3Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 4Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 5Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 6Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 7Genomic DNA Isolation Protocol for 40 l Avian Whole Blood 2DNA/RNA Blotting With the Trans-Blot SD Semi-Dry Electrophoretic Transfer Cell 2
... enrichment of functional endoplasmic reticulum (ER) ... The isolated ER are useful for ... analysis. Metabolic abnornalities of ER include ... fibrosis and many more ER protein ...
Plasmid expressing the LacZ reporter gene....
... 2800mL PYREX Fernbach-style culture flasks have triple ... flask bottom to achieve maximal oxygen transfer ... large marking spot., A wide range of ... including:, Polypropylene colored caps for ease ...
...
Biology Products: