Navigation Links
'Fishy' clue helps establish how proteins evolve
Date:1/27/2009

n synthesis," said Yale postdoctoral fellow and lead co-author Patrick O'Donoghue. "This is the key difference that makes Pyl so interesting and valuable to molecular biologists. It opens the door to engineering the genetic code."

Pyl is so rare that it has been found in only seven organisms. Each of these microbes evolved in an unusual environmental niche and all use methylamines the compounds that make fish smell "fishy" as a source of energy. Sll's research team characterized and crystallized the molecules that "manage" Pyl and created images that show how these molecules have evolved to work together.

"This is the handle we needed to effectively produce an 'expanded' genetic code," said O'Donoghue. "Now we have the ability to directly genetically encode other uncommon amino acids. By doing that, we will be able to isolate the role of particular modifications and to begin to understand their functions and their role in human disease."

"We have found why it is probably not accidental that out of more than 300 amino acids found in natural proteins, only two have been added beyond the standard 20-member amino acid alphabet," said principal investigator Dieter Sll, Sterling Professor of Molecular Biophysics & Biochemistry and professor of chemistry at Yale.

"This work provides a tantalizing glimpse into how proteins have evolved in living cells," said Laurie Tompkins, who oversees protein synthesis grants at the National Institutes of Health's National Institute of General Medical Sciences, which partially supported the work. "The unique way in which the synthetase binds its tRNA substrate is a testament to the ancient roots of this remarkable enzyme."


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fishy future written in the genes
2. Natural chemical found in broccoli helps combat skin blistering disease
3. Device helps patients survive, regain function til transplant
4. Presence of gene mutation helps guide thyroid cancer treatment
5. CABI helps phase out dangerous pesticide in EU
6. Diet support helps chronic kidney patients
7. Argonne helps China create cleaner Beijing for 2008 Olympics
8. A tiny pinch from a z-ring helps bacteria cells divide
9. Ultraviolet light helps to secure water supply
10. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
11. Handbook helps parents deal with childhood infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fishy' clue helps establish how proteins evolve
(Date:10/19/2014)... over the last 30 years contributed only marginally ... that time, according to a new study published ... "Energy access is fundamental to development: it brings ... communication, and health," says IIASA researcher Shonali Pachauri, ... access is widely agreed to be an important ...
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/16/2014)... synthesis of recent research findings to inform their management ... states. , The Ecology and Management of Moist ... of the Relevant Biophysical Science and Implications for Future ... U.S. Forest Service,s Pacific Northwest Research Station, is a ... synthesis of the large body of scientific information on ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... of continental drift provides a good model for understanding terrestrial ... successfully shed light on processes up to 3 billion years ... the earth and crust formation before that point and through ... ago. This is the conclusion of Tomas Naraa of the ...
... tissue using cells derived from the amniotic fluid is ... UCL Institute of Child Health. The paper ... cells derived from the fluids which surround the fetus ... The treatment resulted in longer survival in mice affected ...
... Inc., a Los Angeles based investment banking company, today ... Alliqua, Inc.  During the term of the engagement, WestPark ... and finance, private and public equity and debt financing, ... provide introductions to investors. About Alliqua, ...
Cached Biology News:New understanding of terrestrial formation has significant and far reaching future implications 2Potential new approach to regenerating skeletal muscle tissue 2WestPark Capital, Inc. Engaged By Alliqua, Inc. 2
(Date:10/20/2014)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four ... million and provides a good start to Q4.  The orders are ... and one in the Middle East . ... said Peter Bruijns , President & CEO. "Total bidding activity ... they have been for any complete year since the company has ...
(Date:10/20/2014)... GAITHERSBURG, Md. , Oct. 20, 2014  GenVec, Inc. ... Zola P. Horovitz , Ph.D., from its board of ... GenVec board in August 2003, and served as its chairman ... also served on the Nominating and Corporate Governance and Audit ... Zola for more than a decade of dedicated service to ...
(Date:10/20/2014)... OncLive® is pleased to ... Thomas Jefferson University has joined its Strategic Alliance ... Partnership program, the Sidney Kimmel Cancer Center at ... of the Center’s cutting-edge research programs, comprehensive approach ... other health care professionals from the Sidney Kimmel ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is seeking ... stem cells for dogs with osteoarthritis. Dr. McCarthy has ... clinical stem cell therapy for 7 years. The ultimate ... single injection of donor stem cells into one or ... inflammation in the treated joints. , Candidates for ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... release of GridGain 2.1 - the next version of its innovative ... ... January 13, 2009 -- GridGain Systems is proud to ... its innovative Java-based Open Cloud Platform. GridGain 2.1 provides the industry ...
... Targets Presented At JPMorgan Healthcare Conference SAN FRANCISCO, Jan. ... ) today announced product and operational targets for 2009 ... treatment and position the Company to be cash flow ... presented by Daniel M. Bradbury, president and chief executive ...
... LANSING, Mich., Jan. 12 The Risk Management ... and spring 2009 audio,program calendar. The RM&PSI ... ( http://www.fincorholdings.com ), is a national leader in,clinical ... readiness,practices for health care institutions. , ...
Cached Biology Technology:GridGain 2.1 - Open Cloud Platform Enables Development of Native Cloud Applications 2GridGain 2.1 - Open Cloud Platform Enables Development of Native Cloud Applications 3Amylin Pharmaceuticals Highlights 2009 Value Creation Opportunities 2Amylin Pharmaceuticals Highlights 2009 Value Creation Opportunities 3The Risk Management and Patient Safety Institute Announces Winter and Spring 2009 Audio Program Lineup, Annual Conference Dates 2The Risk Management and Patient Safety Institute Announces Winter and Spring 2009 Audio Program Lineup, Annual Conference Dates 3
Polyclonal Antibody to CLAN...
Request Info...
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: